CXCL16 is elevated in the cerebrospinal fluid versus serum and in inflammatory conditions with suspected and proved central nervous system involvement

Linda M.P. Le Blanc; Antoine W.T. Van Lieshout; Gosse J. Adema; Piet L.C.M. Van Riel; Marcel M. Verbeek; Timothy R.D.J. Radstake

doi:10.1016/j.neulet.2005.12.029

CXCL16 is elevated in the cerebrospinal fluid versus serum and in inflammatory conditions with suspected and proved central nervous system involvement

Linda M.P. Le Blanc, Antoine W.T. Van Lieshout, Gosse J. Adema, Piet L.C.M. Van Riel, Marcel M. Verbeek, Timothy R.D.J. Radstake^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

30 Citations (Scopus)

Abstract

In neuro-inflammatory diseases, activated T cells are thought to drive the inflammatory process. In this study, we investigated the potential role of three T cell attracting chemokines (CK) in neuro-inflammation. For this purpose, we measured levels of CXCL16, CCL17 and CCL18 in matched serum and cerebrospinal fluid (CSF) samples of patients with different neurological diseases. Interestingly, CXCL16 levels were significantly elevated in the CSF and were higher in inflammatory disease than in controls, whereas CCL17 and CCL18 were absent in the CSF. CCL18 was only elevated in serum of SLE patients. These data suggest that attraction of activated memory type T cells by CXCL16 might play an important role in the orchestration of immune responses in the central nervous system.

Original language	English
Pages (from-to)	145-148
Number of pages	4
Journal	Neuroscience Letters
Volume	397
Issue number	1-2
DOIs	https://doi.org/10.1016/j.neulet.2005.12.029
Publication status	Published - 10 Apr 2006

Keywords

CCL17
CCL18
Cerebrospinal fluid
Chemokines
CXCL16
Systemic lupus erythematosus (SLE)

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10.1016/j.neulet.2005.12.029

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title = "CXCL16 is elevated in the cerebrospinal fluid versus serum and in inflammatory conditions with suspected and proved central nervous system involvement",

abstract = "In neuro-inflammatory diseases, activated T cells are thought to drive the inflammatory process. In this study, we investigated the potential role of three T cell attracting chemokines (CK) in neuro-inflammation. For this purpose, we measured levels of CXCL16, CCL17 and CCL18 in matched serum and cerebrospinal fluid (CSF) samples of patients with different neurological diseases. Interestingly, CXCL16 levels were significantly elevated in the CSF and were higher in inflammatory disease than in controls, whereas CCL17 and CCL18 were absent in the CSF. CCL18 was only elevated in serum of SLE patients. These data suggest that attraction of activated memory type T cells by CXCL16 might play an important role in the orchestration of immune responses in the central nervous system.",

keywords = "CCL17, CCL18, Cerebrospinal fluid, Chemokines, CXCL16, Systemic lupus erythematosus (SLE)",

author = "{Le Blanc}, {Linda M.P.} and {Van Lieshout}, {Antoine W.T.} and Adema, {Gosse J.} and {Van Riel}, {Piet L.C.M.} and Verbeek, {Marcel M.} and Radstake, {Timothy R.D.J.}",

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doi = "10.1016/j.neulet.2005.12.029",

language = "English",

volume = "397",

pages = "145--148",

journal = "Neuroscience Letters",

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CXCL16 is elevated in the cerebrospinal fluid versus serum and in inflammatory conditions with suspected and proved central nervous system involvement. / Le Blanc, Linda M.P.; Van Lieshout, Antoine W.T.; Adema, Gosse J. et al.
In: Neuroscience Letters, Vol. 397, No. 1-2, 10.04.2006, p. 145-148.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - CXCL16 is elevated in the cerebrospinal fluid versus serum and in inflammatory conditions with suspected and proved central nervous system involvement

AU - Le Blanc, Linda M.P.

AU - Van Lieshout, Antoine W.T.

AU - Adema, Gosse J.

AU - Van Riel, Piet L.C.M.

AU - Verbeek, Marcel M.

AU - Radstake, Timothy R.D.J.

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AB - In neuro-inflammatory diseases, activated T cells are thought to drive the inflammatory process. In this study, we investigated the potential role of three T cell attracting chemokines (CK) in neuro-inflammation. For this purpose, we measured levels of CXCL16, CCL17 and CCL18 in matched serum and cerebrospinal fluid (CSF) samples of patients with different neurological diseases. Interestingly, CXCL16 levels were significantly elevated in the CSF and were higher in inflammatory disease than in controls, whereas CCL17 and CCL18 were absent in the CSF. CCL18 was only elevated in serum of SLE patients. These data suggest that attraction of activated memory type T cells by CXCL16 might play an important role in the orchestration of immune responses in the central nervous system.

KW - CCL17

KW - CCL18

KW - Cerebrospinal fluid

KW - Chemokines

KW - CXCL16

KW - Systemic lupus erythematosus (SLE)

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SN - 0304-3940

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SP - 145

EP - 148

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 1-2

ER -

CXCL16 is elevated in the cerebrospinal fluid versus serum and in inflammatory conditions with suspected and proved central nervous system involvement

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Keywords

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