CX(3)CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance

JH Niess, S Brand, XB Gu, L Landsman, S Jung, BA McCormick, JM Vyas, M Boes, HL Ploegh, JG Fox, DR Littman, HC Reinecker*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Dendritic cells (DCs) and macrophages are critical to innate and adaptive immunity to the intestinal bacterial microbiota. Here, we identify a myeloid-derived mucosal DC in mice, which populates the entire lamina propria of the small intestine. Lamina propria DCs were found to depend on the chemokine receptor CX(3)CR1 to form transepithelial dendrites, which enable the cells to directly sample luminal antigens. CX(3)CR1 was also found to control the clearance of entero-invasive pathogens by DCs. Thus, CX(3)C1-dependent processes, which control host interactions of specialized DCs with commensal and pathogenic bacteria, may regulate immunological tolerance and inflammation.

Original languageEnglish
Pages (from-to)254-258
Number of pages5
JournalScience
Volume307
Issue number5707
DOIs
Publication statusPublished - 14 Jan 2005

Keywords

  • PEYERS PATCH
  • IMMUNE-RESPONSES
  • FRACTALKINE
  • EPITHELIUM
  • LOCALIZATION
  • CHEMOKINE
  • SUBSETS
  • GUT

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