Currently known risk factors for hypertrophic skin scarring: A review

L. Butzelaar*, M. M W Ulrich, A. B. Mink Van Der Molen, F. B. Niessen, R. H J Beelen

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    5 Citations (Scopus)


    SummaryObjective The study aims to provide an overview of risk factors for hypertrophic scarring. Background Hypertrophic skin scarring remains a major concern in medicine and causes considerable morbidity. Despite extensive research on this topic, the precise mechanism of excessive scarring is still unknown. In addition, the current literature lacks an overview of the possible risk factors in the development of hypertrophic scars. Methods PubMed searches were performed on risk factors for hypertrophic scar (HTS) formation. Results Eleven studies suggesting nine factors associated with HTS formation were found. Studies concerning chemotherapy, age, stretch, infection, and smoking have a moderate to high strength of evidence, but some other factors have not been studied in a convincing manner or are still disputed. Conclusions Risk factors for HTS formation are young age, bacterial colonization, and skin subjected to stretch. Chemotherapy, statins, and smoking seem to play a protective role in HTS formation.

    Original languageEnglish
    Pages (from-to)163-169
    Number of pages7
    JournalJournal of Plastic, Reconstructive & Aesthetic Surgery
    Issue number2
    Publication statusPublished - 1 Feb 2016


    • Excessive scarring
    • Hypertrophic scar
    • Risk factors
    • Skin
    • Wound healing
    • review


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