TY - JOUR
T1 - Current and Future Biomarkers in Atopic Dermatitis
AU - Thijs, Judith L.
AU - de Bruin-Weller, Marjolein S.
AU - Hijnen, Dirk Jan
N1 - Publisher Copyright:
© 2016 Elsevier Inc.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2017/2
Y1 - 2017/2
N2 - Atopic dermatitis (AD) is a heterogeneous disease and many attempts have been made to define subsets of patients based on clinical characteristics. However, the current characterization of patients with AD might not adequately reflect the pathophysiologic diversity within patients with AD. This article reviews current biomarkers for AD and future perspectives. In the future, patients with AD will be stratified based on biomarker expression levels in body fluids and tissue, genetic variants, or combined biomarker expression patterns. With new targeted therapies for AD currently investigated in clinical trials this will lead to better identification of patients that can benefit from these highly specific, but expensive new treatments.
AB - Atopic dermatitis (AD) is a heterogeneous disease and many attempts have been made to define subsets of patients based on clinical characteristics. However, the current characterization of patients with AD might not adequately reflect the pathophysiologic diversity within patients with AD. This article reviews current biomarkers for AD and future perspectives. In the future, patients with AD will be stratified based on biomarker expression levels in body fluids and tissue, genetic variants, or combined biomarker expression patterns. With new targeted therapies for AD currently investigated in clinical trials this will lead to better identification of patients that can benefit from these highly specific, but expensive new treatments.
KW - Atopic dermatitis
KW - Biologicals
KW - Biomarkers
KW - Disease severity
KW - Heterogeneity
KW - Personalized medicine
KW - Stratification
UR - http://www.scopus.com/inward/record.url?scp=84996938709&partnerID=8YFLogxK
U2 - 10.1016/j.iac.2016.08.008
DO - 10.1016/j.iac.2016.08.008
M3 - Article
C2 - 27886910
AN - SCOPUS:84996938709
SN - 0889-8561
VL - 37
SP - 51
EP - 61
JO - Immunology and Allergy Clinics of North America
JF - Immunology and Allergy Clinics of North America
IS - 1
ER -