Cryptococcus neoformans and neutrophil migration

P.M. Ellerbroek

Cryptococcus neoformans and neutrophil migration

P.M. Ellerbroek

Internal Medicine

Research output: Thesis › Doctoral thesis 1 (Research UU / Graduation UU)

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Abstract

This thesis has focused on several aspects of cryptococcal glucuronoxylomannan (GXM)-related interference with neutrophil migration into inflammatory sites. First, the effect of GXM on neutrophil adhesion (rolling and firm adhesion) to the endothelium was investigated and potential mechanisms were explored. Second, we investigated the outcome of GXM treatment on neutrophil recruitment in a model of myocardial ischemia. Finally, we examined the role of certain structural elements of GXM in the effects on neutrophil migration.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	Utrecht University
Supervisors/Advisors	Hoepelman, Andy, Primary supervisor Coenjaerts, FEJ, Co-supervisor
Award date	11 Jun 2004
Place of Publication	Enschede
Publisher	Febodruk B.V.
Print ISBNs	90-9018101-6
Publication status	Published - 11 Jun 2004

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title = "Cryptococcus neoformans and neutrophil migration",

abstract = "This thesis has focused on several aspects of cryptococcal glucuronoxylomannan (GXM)-related interference with neutrophil migration into inflammatory sites. First, the effect of GXM on neutrophil adhesion (rolling and firm adhesion) to the endothelium was investigated and potential mechanisms were explored. Second, we investigated the outcome of GXM treatment on neutrophil recruitment in a model of myocardial ischemia. Finally, we examined the role of certain structural elements of GXM in the effects on neutrophil migration.",

author = "P.M. Ellerbroek",

year = "2004",

month = jun,

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language = "English",

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publisher = "Febodruk B.V.",

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T1 - Cryptococcus neoformans and neutrophil migration

AU - Ellerbroek, P.M.

PY - 2004/6/11

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N2 - This thesis has focused on several aspects of cryptococcal glucuronoxylomannan (GXM)-related interference with neutrophil migration into inflammatory sites. First, the effect of GXM on neutrophil adhesion (rolling and firm adhesion) to the endothelium was investigated and potential mechanisms were explored. Second, we investigated the outcome of GXM treatment on neutrophil recruitment in a model of myocardial ischemia. Finally, we examined the role of certain structural elements of GXM in the effects on neutrophil migration.

AB - This thesis has focused on several aspects of cryptococcal glucuronoxylomannan (GXM)-related interference with neutrophil migration into inflammatory sites. First, the effect of GXM on neutrophil adhesion (rolling and firm adhesion) to the endothelium was investigated and potential mechanisms were explored. Second, we investigated the outcome of GXM treatment on neutrophil recruitment in a model of myocardial ischemia. Finally, we examined the role of certain structural elements of GXM in the effects on neutrophil migration.

M3 - Doctoral thesis 1 (Research UU / Graduation UU)

SN - 90-9018101-6

PB - Febodruk B.V.

CY - Enschede

ER -

Cryptococcus neoformans and neutrophil migration

Abstract

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