Cryptococcal glucuronoxylomannan delays translocation of leukocytes across the blood-brain barrier in an animal model of acute bacterial meningitis

Myriam M. Lipovsky, Liana Tsenova, Frank E.J. Coenjaerts, Gilla Kaplan, Robert Cherniak, Andy I.M. Hoepelman*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

23 Citations (Scopus)

Abstract

In bacterial meningitis, neurological damage is associated with a high influx of polymorphonuclear leukocytes (PMN) into the brain. Previous data suggest that the capsular component of the fungus C. neoformans, glucuronoxylomannan (GXM), interferes with PMN-migration into the cerebrospinal fluid (CSF). Therefore, a rabbit model of bacterial meningitis was treated intravenously with GXM. This resulted in (1) a reduction of PMN in the CSF at 6 h (P=0.05), (2) reduced peak TNF-α concentrations in the CSF, and (3) diminished tissue inflammation and intravascular margination of PMN in GXM-treated animals. Thus, GXM may represent a novel adjuvant anti-inflammatory agent in bacterial meningitis. Copyright (C) 2000 .

Original languageEnglish
Pages (from-to)10-14
Number of pages5
JournalJournal of Neuroimmunology
Volume111
Issue number1-2
DOIs
Publication statusPublished - 1 Nov 2000

Keywords

  • Bacterial meningitis
  • GXM
  • Inflammation
  • Leukocytes

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