TY - JOUR
T1 - Cryptococcal glucuronoxylomannan delays translocation of leukocytes across the blood-brain barrier in an animal model of acute bacterial meningitis
AU - Lipovsky, Myriam M.
AU - Tsenova, Liana
AU - Coenjaerts, Frank E.J.
AU - Kaplan, Gilla
AU - Cherniak, Robert
AU - Hoepelman, Andy I.M.
PY - 2000/11/1
Y1 - 2000/11/1
N2 - In bacterial meningitis, neurological damage is associated with a high influx of polymorphonuclear leukocytes (PMN) into the brain. Previous data suggest that the capsular component of the fungus C. neoformans, glucuronoxylomannan (GXM), interferes with PMN-migration into the cerebrospinal fluid (CSF). Therefore, a rabbit model of bacterial meningitis was treated intravenously with GXM. This resulted in (1) a reduction of PMN in the CSF at 6 h (P=0.05), (2) reduced peak TNF-α concentrations in the CSF, and (3) diminished tissue inflammation and intravascular margination of PMN in GXM-treated animals. Thus, GXM may represent a novel adjuvant anti-inflammatory agent in bacterial meningitis. Copyright (C) 2000 .
AB - In bacterial meningitis, neurological damage is associated with a high influx of polymorphonuclear leukocytes (PMN) into the brain. Previous data suggest that the capsular component of the fungus C. neoformans, glucuronoxylomannan (GXM), interferes with PMN-migration into the cerebrospinal fluid (CSF). Therefore, a rabbit model of bacterial meningitis was treated intravenously with GXM. This resulted in (1) a reduction of PMN in the CSF at 6 h (P=0.05), (2) reduced peak TNF-α concentrations in the CSF, and (3) diminished tissue inflammation and intravascular margination of PMN in GXM-treated animals. Thus, GXM may represent a novel adjuvant anti-inflammatory agent in bacterial meningitis. Copyright (C) 2000 .
KW - Bacterial meningitis
KW - GXM
KW - Inflammation
KW - Leukocytes
UR - http://www.scopus.com/inward/record.url?scp=0034333275&partnerID=8YFLogxK
U2 - 10.1016/S0165-5728(00)00354-4
DO - 10.1016/S0165-5728(00)00354-4
M3 - Article
C2 - 11063816
AN - SCOPUS:0034333275
SN - 0165-5728
VL - 111
SP - 10
EP - 14
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
IS - 1-2
ER -