@article{05a5517e9cec4f53b79876bca4663ee0,
title = "Crowning the Kinetochore: The Fibrous Corona in Chromosome Segregation",
abstract = "The kinetochore is at the heart of chromosome segregation in mitosis and meiosis. Rather than a static linker complex for chromatin and spindle microtubules, it is highly dynamic in composition, size, and shape. While known for decades that it can expand and grow a fibrous meshwork known as the corona, it was until recently unclear what constitutes this {\textquoteleft}crown{\textquoteright} and what its relevance is for kinetochore function. Here, we highlight recent discoveries in fibrous corona biology, and place them in the context of the processes that orchestrate high-fidelity chromosome segregation.",
keywords = "cell division, chromosome, dynein, kinetochore, microtubule, spindle assembly checkpoint",
author = "Kops, {Geert J.P.L.} and Reto Gassmann",
note = "Funding Information: We thank our lab members and Alexey Khodjakov for comments on the manuscript, and Alexey Khodjakov for kindly providing the EM images in Figures 1 and 4 . Work in the Kops laboratory is supported by Oncode Institute, which is partly financed by the Dutch Cancer Society , and by KWF grant 11080. Work in the Gassmann lab is supported by the Funda{\c c}{\~a}o para a Ci{\^e}ncia e a Tecnologia / Minist{\'e}rio da Ci{\^e}ncia, Tecnologia e Ensino Superior through project grant NORTE-01-0145-FEDER-030507 and fellowship CEECIND/00333/2017. Funding Information: We thank our lab members and Alexey Khodjakov for comments on the manuscript, and Alexey Khodjakov for kindly providing the EM images in Figures 1 and 4. Work in the Kops laboratory is supported by Oncode Institute, which is partly financed by the Dutch Cancer Society, and by KWF grant 11080. Work in the Gassmann lab is supported by the Funda??o para a Ci?ncia e a Tecnologia/Minist?rio da Ci?ncia, Tecnologia e Ensino Superior through project grant NORTE-01-0145-FEDER-030507 and fellowship CEECIND/00333/2017. Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd",
year = "2020",
month = aug,
doi = "10.1016/j.tcb.2020.04.006",
language = "English",
volume = "30",
pages = "653--667",
journal = "Trends in Cell Biology",
issn = "0962-8924",
publisher = "Elsevier Limited",
number = "8",
}