Crowning the Kinetochore: The Fibrous Corona in Chromosome Segregation

Geert J.P.L. Kops*, Reto Gassmann

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    Abstract

    The kinetochore is at the heart of chromosome segregation in mitosis and meiosis. Rather than a static linker complex for chromatin and spindle microtubules, it is highly dynamic in composition, size, and shape. While known for decades that it can expand and grow a fibrous meshwork known as the corona, it was until recently unclear what constitutes this ‘crown’ and what its relevance is for kinetochore function. Here, we highlight recent discoveries in fibrous corona biology, and place them in the context of the processes that orchestrate high-fidelity chromosome segregation.

    Original languageEnglish
    Pages (from-to)653-667
    Number of pages15
    JournalTrends in Cell Biology
    Volume30
    Issue number8
    DOIs
    Publication statusPublished - Aug 2020

    Keywords

    • cell division
    • chromosome
    • dynein
    • kinetochore
    • microtubule
    • spindle assembly checkpoint

    Fingerprint

    Dive into the research topics of 'Crowning the Kinetochore: The Fibrous Corona in Chromosome Segregation'. Together they form a unique fingerprint.

    Cite this