Cross-talk between tumor and myeloid cells: how to tip the balance in favor of antitumor immunity

Jelle J Lindenberg, Cynthia M Fehres, Hester van Cruijsen, Dinja Oosterhoff, Tanja D de Gruijl

Research output: Contribution to journalArticleAcademicpeer-review


Myeloid differentiation is often disturbed in cancer, leading to reduced frequencies of immunostimulatory dendritic cells and an over-representation of immunosuppressive immature myeloid cells, granulocytes and macrophages. As a result of this skewed myeloid differentiation, a highly immunosuppressive myeloid subset becomes prevalent during cancer development; these myeloid-derived suppressor cells are also recruited as a collateral to certain protumorigenic inflammatory processes, resulting in an effective downregulation of T-cell-mediated immune surveillance and antitumor immunity. In this article, some of the important myeloid cell subsets and mediators involved in cancer-related immune suppression are reviewed. Furthermore, cross-talk between tumors and the myeloid compartment, and ways in which it can suppress effective cell-mediated immunity, are discussed, as well as possible therapeutic approaches to tip the balance in favor of antitumor immunity.

Original languageEnglish
Pages (from-to)77-96
Number of pages20
Issue number1
Publication statusPublished - Jan 2011


  • Animals
  • Cell Communication
  • Cell Differentiation
  • Dendritic Cells
  • Humans
  • Immunity, Cellular
  • Immunosuppression
  • Mice
  • Myeloid Cells
  • Neoplasms


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