Abstract
The roles of connective tissue growth factor (CTGF) and transforming growth factor-Β (TGF-Β), both well-known collagen production stimulators, were examined in skin aging. Aged skin and fibroblasts exhibited a coordinate decrease in CTGF, TGF-Β, and type I procollagen expression and content. CTGF knockdown and TGF-Β blockade in normal dermal fibroblasts reduced procollagen expression, whereas overexpressing CTGF increased procollagen by a TGF-Β/Smad signaling-dependent mechanism without involving Smad2/3.
| Original language | English |
|---|---|
| Pages (from-to) | 338-341 |
| Number of pages | 4 |
| Journal | Journal of Investigative Dermatology |
| Volume | 130 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 2010 |