Costs and effects of chlamydial screening: dynamic versus static modeling

Robert Welte, Maarten Postma, Reiner Leidl, Mirjam Kretzschmar

Research output: Contribution to journalArticleAcademicpeer-review


OBJECTIVE: The objective of this study was to assess the impact of modeling type on the economic evaluation of screening programs for asymptomatic Chlamydia trachomatis infections.

STUDY: We compared a stochastic network simulation model (dynamic model) with a decision analysis model (static model) for estimating the cost-effectiveness of an opportunistic screening program. The influence of the model type on the required data, the computed results, and the sensitivity of model parameters were investigated.

RESULTS: When compared with static modeling, dynamic modeling yielded different cost-effectiveness ratios and identified other optimal screening strategies as it considers changes in the force of infection caused by screening. However, it is more complex, data- and time-demanding, and more sensitive to some parameters affecting the force of infection than static modeling.

CONCLUSIONS: Dynamic models should be applied for the economic evaluation of prevention measures that have the potential to lower the force of infection such as large-scale chlamydial screening programs.

Original languageEnglish
Pages (from-to)474-83
Number of pages10
JournalSexually Transmitted Diseases
Issue number8
Publication statusPublished - Aug 2005


  • Adolescent
  • Adult
  • Chlamydia Infections/diagnosis
  • Chlamydia trachomatis
  • Cost-Benefit Analysis
  • Decision Support Techniques
  • Female
  • Humans
  • Male
  • Mass Screening/economics
  • Models, Econometric
  • Netherlands/epidemiology
  • Stochastic Processes


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