Cost-utility of an eHealth application 'Oncokompas' that supports cancer survivors in self-management: results of a randomised controlled trial

A van der Hout; F Jansen; C F van Uden-Kraan; V M Coupé; K Holtmaat; G A Nieuwenhuijzen; J A Hardillo; R J Baatenburg de Jong; N L Tiren-Verbeet; D W Sommeijer; K de Heer; C G Schaar; R J E Sedee; K Bosscha; M W M van den Brekel; J F Petersen; M Westerman; J Honings; R P Takes; I Houtenbos; W T van den Broek; R de Bree; P Jansen; S E J Eerenstein; C R Leemans; J M Zijlstra; P Cuijpers; L V van de Poll-Franse; I M Verdonck-de Leeuw

doi:10.1007/s11764-020-00912-9

Cost-utility of an eHealth application 'Oncokompas' that supports cancer survivors in self-management: results of a randomised controlled trial

A van der Hout
, F Jansen
, C F van Uden-Kraan
, V M Coupé
, K Holtmaat
, G A Nieuwenhuijzen
, J A Hardillo
, R J Baatenburg de Jong
, N L Tiren-Verbeet
, D W Sommeijer
, K de Heer
, C G Schaar
, R J E Sedee
, K Bosscha
, M W M van den Brekel
, J F Petersen
, M Westerman
, J Honings
, R P Takes
, I Houtenbos

W T van den Broek, R de Bree, P Jansen, S E J Eerenstein, C R Leemans, J M Zijlstra, P Cuijpers, L V van de Poll-Franse, I M Verdonck-de Leeuw

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

PURPOSE: The eHealth self-management application 'Oncokompas' was developed to support cancer survivors in monitoring health-related quality of life (HRQOL) and symptoms, and obtaining personalized feedback and options for supportive care. The aim of this study was to assess the cost-utility of Oncokompas compared with care as usual (CAU) among cancer survivors.

METHODS: Survivors were randomly allocated to the intervention or control group. Direct (non-)medical, indirect non-medical costs, and HRQOL were measured at 3- and 6-month follow-up, using iMTA Medical Consumption and Productivity Costs and the EuroQol-5D questionnaires. Mean cumulative costs and quality-adjusted life-years (QALYs) were compared between both groups.

RESULTS: In total, 625 survivors were randomized into intervention (n = 320) or control group (n = 305). Base case analysis showed that incremental costs from a societal perspective were - €163 (95% CI, - 665 to 326), and incremental QALYs were 0.0017 (95% CI, - 0.0121 to 0.0155) in the intervention group compared with those in the control group. The probability that, compared with CAU, Oncokompas is more effective was 60%, less costly 73%, and both more effective and less costly 47%. Sensitivity analyses showed that incremental costs vary between - €40 and €69, and incremental QALYs vary between - 0.0023 and - 0.0057.

CONCLUSION: Oncokompas is likely to be equally effective on utilities, and not more expensive than CAU, and will therefore contribute to sustainable cancer survivorship care in a (cost-)effective manner.

IMPLICATIONS FOR CANCER SURVIVORS: Oncokompas seems to improve HRQOL and reduces the burden of several tumour-specific symptoms, while costs from a societal perspective are similar to CAU.

Original language	English
Pages (from-to)	77-86
Number of pages	10
Journal	Journal of cancer survivorship : research and practice
Volume	15
Issue number	1
DOIs	https://doi.org/10.1007/s11764-020-00912-9
Publication status	Published - Feb 2021

Keywords

Cancer survivorship
Cost-utility
eHealth
Quality of life
Self-management
Supportive care

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10.1007/s11764-020-00912-9

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van der Hout, A., Jansen, F., van Uden-Kraan, C. F., Coupé, V. M., Holtmaat, K., Nieuwenhuijzen, G. A., Hardillo, J. A., de Jong, R. J. B., Tiren-Verbeet, N. L., Sommeijer, D. W., de Heer, K., Schaar, C. G., Sedee, R. J. E., Bosscha, K., van den Brekel, M. W. M., Petersen, J. F., Westerman, M., Honings, J., Takes, R. P., ... Verdonck-de Leeuw, I. M. (2021). Cost-utility of an eHealth application 'Oncokompas' that supports cancer survivors in self-management: results of a randomised controlled trial. Journal of cancer survivorship : research and practice, 15(1), 77-86. https://doi.org/10.1007/s11764-020-00912-9

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title = "Cost-utility of an eHealth application 'Oncokompas' that supports cancer survivors in self-management: results of a randomised controlled trial",

abstract = "PURPOSE: The eHealth self-management application 'Oncokompas' was developed to support cancer survivors in monitoring health-related quality of life (HRQOL) and symptoms, and obtaining personalized feedback and options for supportive care. The aim of this study was to assess the cost-utility of Oncokompas compared with care as usual (CAU) among cancer survivors.METHODS: Survivors were randomly allocated to the intervention or control group. Direct (non-)medical, indirect non-medical costs, and HRQOL were measured at 3- and 6-month follow-up, using iMTA Medical Consumption and Productivity Costs and the EuroQol-5D questionnaires. Mean cumulative costs and quality-adjusted life-years (QALYs) were compared between both groups.RESULTS: In total, 625 survivors were randomized into intervention (n = 320) or control group (n = 305). Base case analysis showed that incremental costs from a societal perspective were - €163 (95\% CI, - 665 to 326), and incremental QALYs were 0.0017 (95\% CI, - 0.0121 to 0.0155) in the intervention group compared with those in the control group. The probability that, compared with CAU, Oncokompas is more effective was 60\%, less costly 73\%, and both more effective and less costly 47\%. Sensitivity analyses showed that incremental costs vary between - €40 and €69, and incremental QALYs vary between - 0.0023 and - 0.0057.CONCLUSION: Oncokompas is likely to be equally effective on utilities, and not more expensive than CAU, and will therefore contribute to sustainable cancer survivorship care in a (cost-)effective manner.IMPLICATIONS FOR CANCER SURVIVORS: Oncokompas seems to improve HRQOL and reduces the burden of several tumour-specific symptoms, while costs from a societal perspective are similar to CAU.",

keywords = "Cancer survivorship, Cost-utility, eHealth, Quality of life, Self-management, Supportive care",

author = "\{van der Hout\}, A and F Jansen and \{van Uden-Kraan\}, \{C F\} and Coup{\'e}, \{V M\} and K Holtmaat and Nieuwenhuijzen, \{G A\} and Hardillo, \{J A\} and \{de Jong\}, \{R J Baatenburg\} and Tiren-Verbeet, \{N L\} and Sommeijer, \{D W\} and \{de Heer\}, K and Schaar, \{C G\} and Sedee, \{R J E\} and K Bosscha and \{van den Brekel\}, \{M W M\} and Petersen, \{J F\} and M Westerman and J Honings and Takes, \{R P\} and I Houtenbos and \{van den Broek\}, \{W T\} and \{de Bree\}, R and P Jansen and Eerenstein, \{S E J\} and Leemans, \{C R\} and Zijlstra, \{J M\} and P Cuijpers and \{van de Poll-Franse\}, \{L V\} and \{Verdonck-de Leeuw\}, \{I M\}",

note = "Funding Information: IMV-dL has received grants from the Dutch Cancer Society (KWF Kankerbestrijding), Pink Ribbon, the Netherlands Organization for Health Research and Development (ZonMW), the SAG Foundation–Zilveren Kruis Health Care Assurance Company, Danone Ecofund–Nutricia, Red-kite (distributor of eHealth tools), and Bristol-Myers Squibb, during the conduct of this study. CRL has received personal fees for global advisory board participation from MSD, during the conduct of this study. All other authors have no conflicts of interest. Funding Information: This study was funded by the Dutch Cancer Society (KWF Kankerbestrijding) (grant number VU 2014-7202). Publisher Copyright: {\textcopyright} 2020, The Author(s).",

year = "2021",

month = feb,

doi = "10.1007/s11764-020-00912-9",

language = "English",

volume = "15",

pages = "77--86",

journal = "Journal of cancer survivorship : research and practice",

issn = "1932-2259",

publisher = "Springer New York",

number = "1",

}

van der Hout, A, Jansen, F, van Uden-Kraan, CF, Coupé, VM, Holtmaat, K, Nieuwenhuijzen, GA, Hardillo, JA, de Jong, RJB, Tiren-Verbeet, NL, Sommeijer, DW, de Heer, K, Schaar, CG, Sedee, RJE, Bosscha, K, van den Brekel, MWM, Petersen, JF, Westerman, M, Honings, J, Takes, RP, Houtenbos, I, van den Broek, WT, de Bree, R, Jansen, P, Eerenstein, SEJ, Leemans, CR, Zijlstra, JM, Cuijpers, P, van de Poll-Franse, LV & Verdonck-de Leeuw, IM 2021, 'Cost-utility of an eHealth application 'Oncokompas' that supports cancer survivors in self-management: results of a randomised controlled trial', Journal of cancer survivorship : research and practice, vol. 15, no. 1, pp. 77-86. https://doi.org/10.1007/s11764-020-00912-9

Cost-utility of an eHealth application 'Oncokompas' that supports cancer survivors in self-management: results of a randomised controlled trial. / van der Hout, A; Jansen, F; van Uden-Kraan, C F et al.
In: Journal of cancer survivorship : research and practice, Vol. 15, No. 1, 02.2021, p. 77-86.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Cost-utility of an eHealth application 'Oncokompas' that supports cancer survivors in self-management

T2 - results of a randomised controlled trial

AU - van der Hout, A

AU - Jansen, F

AU - van Uden-Kraan, C F

AU - Coupé, V M

AU - Holtmaat, K

AU - Nieuwenhuijzen, G A

AU - Hardillo, J A

AU - de Jong, R J Baatenburg

AU - Tiren-Verbeet, N L

AU - Sommeijer, D W

AU - de Heer, K

AU - Schaar, C G

AU - Sedee, R J E

AU - Bosscha, K

AU - van den Brekel, M W M

AU - Petersen, J F

AU - Westerman, M

AU - Honings, J

AU - Takes, R P

AU - Houtenbos, I

AU - van den Broek, W T

AU - de Bree, R

AU - Jansen, P

AU - Eerenstein, S E J

AU - Leemans, C R

AU - Zijlstra, J M

AU - Cuijpers, P

AU - van de Poll-Franse, L V

AU - Verdonck-de Leeuw, I M

N1 - Funding Information: IMV-dL has received grants from the Dutch Cancer Society (KWF Kankerbestrijding), Pink Ribbon, the Netherlands Organization for Health Research and Development (ZonMW), the SAG Foundation–Zilveren Kruis Health Care Assurance Company, Danone Ecofund–Nutricia, Red-kite (distributor of eHealth tools), and Bristol-Myers Squibb, during the conduct of this study. CRL has received personal fees for global advisory board participation from MSD, during the conduct of this study. All other authors have no conflicts of interest. Funding Information: This study was funded by the Dutch Cancer Society (KWF Kankerbestrijding) (grant number VU 2014-7202). Publisher Copyright: © 2020, The Author(s).

PY - 2021/2

Y1 - 2021/2

N2 - PURPOSE: The eHealth self-management application 'Oncokompas' was developed to support cancer survivors in monitoring health-related quality of life (HRQOL) and symptoms, and obtaining personalized feedback and options for supportive care. The aim of this study was to assess the cost-utility of Oncokompas compared with care as usual (CAU) among cancer survivors.METHODS: Survivors were randomly allocated to the intervention or control group. Direct (non-)medical, indirect non-medical costs, and HRQOL were measured at 3- and 6-month follow-up, using iMTA Medical Consumption and Productivity Costs and the EuroQol-5D questionnaires. Mean cumulative costs and quality-adjusted life-years (QALYs) were compared between both groups.RESULTS: In total, 625 survivors were randomized into intervention (n = 320) or control group (n = 305). Base case analysis showed that incremental costs from a societal perspective were - €163 (95% CI, - 665 to 326), and incremental QALYs were 0.0017 (95% CI, - 0.0121 to 0.0155) in the intervention group compared with those in the control group. The probability that, compared with CAU, Oncokompas is more effective was 60%, less costly 73%, and both more effective and less costly 47%. Sensitivity analyses showed that incremental costs vary between - €40 and €69, and incremental QALYs vary between - 0.0023 and - 0.0057.CONCLUSION: Oncokompas is likely to be equally effective on utilities, and not more expensive than CAU, and will therefore contribute to sustainable cancer survivorship care in a (cost-)effective manner.IMPLICATIONS FOR CANCER SURVIVORS: Oncokompas seems to improve HRQOL and reduces the burden of several tumour-specific symptoms, while costs from a societal perspective are similar to CAU.

AB - PURPOSE: The eHealth self-management application 'Oncokompas' was developed to support cancer survivors in monitoring health-related quality of life (HRQOL) and symptoms, and obtaining personalized feedback and options for supportive care. The aim of this study was to assess the cost-utility of Oncokompas compared with care as usual (CAU) among cancer survivors.METHODS: Survivors were randomly allocated to the intervention or control group. Direct (non-)medical, indirect non-medical costs, and HRQOL were measured at 3- and 6-month follow-up, using iMTA Medical Consumption and Productivity Costs and the EuroQol-5D questionnaires. Mean cumulative costs and quality-adjusted life-years (QALYs) were compared between both groups.RESULTS: In total, 625 survivors were randomized into intervention (n = 320) or control group (n = 305). Base case analysis showed that incremental costs from a societal perspective were - €163 (95% CI, - 665 to 326), and incremental QALYs were 0.0017 (95% CI, - 0.0121 to 0.0155) in the intervention group compared with those in the control group. The probability that, compared with CAU, Oncokompas is more effective was 60%, less costly 73%, and both more effective and less costly 47%. Sensitivity analyses showed that incremental costs vary between - €40 and €69, and incremental QALYs vary between - 0.0023 and - 0.0057.CONCLUSION: Oncokompas is likely to be equally effective on utilities, and not more expensive than CAU, and will therefore contribute to sustainable cancer survivorship care in a (cost-)effective manner.IMPLICATIONS FOR CANCER SURVIVORS: Oncokompas seems to improve HRQOL and reduces the burden of several tumour-specific symptoms, while costs from a societal perspective are similar to CAU.

KW - Cancer survivorship

KW - Cost-utility

KW - eHealth

KW - Quality of life

KW - Self-management

KW - Supportive care

UR - https://www.scopus.com/pages/publications/85087776668

U2 - 10.1007/s11764-020-00912-9

DO - 10.1007/s11764-020-00912-9

M3 - Article

C2 - 32656739

SN - 1932-2259

VL - 15

SP - 77

EP - 86

JO - Journal of cancer survivorship : research and practice

JF - Journal of cancer survivorship : research and practice

IS - 1

ER -

Cost-utility of an eHealth application 'Oncokompas' that supports cancer survivors in self-management: results of a randomised controlled trial

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