Cost-effectiveness of the coronary sinus Reducer and its impact on the healthcare burden of refractory angina patients

Guglielmo Gallone, Patrizio Armeni, Stefan Verheye, Pierfrancesco Agostoni, Leo Timmers, Gianluca Campo, Alfonso Ielasi, Fabio Sgura, Giuseppe Tarantini, Liesbeth Rosseel, Carlo Zivelonghi, Geert Leenders, Pieter Stella, Matteo Tebaldi, Maurizio Tespili, Gianpiero D'Amico, Luca Baldetti, Francesco Ponticelli, Antonio Colombo, Francesco Giannini

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Aims The coronary sinus Reducer is a percutaneous device proven to improve angina symptoms in refractory angina (RA). We evaluated its potential cost-effectiveness and impact on the healthcare resource use. Methods Angina-related healthcare resource usage and quality-of-life data were collected for 215 consecutive RA patients and results undergoing Reducer implantation in Belgium, the Netherlands, and Italy. Costs were assessed from each country’s healthcare system perspective. Data from the date of RA diagnosis to Reducer implantation [Standard-of-Care (SoC)-period] and from Reducer implantation to follow-up (Reducer-period) were compared: during Reducer-period, a significant reduction in angina-driven hospitalizations, outpatient visits, coronary angiograms, and percutaneous coronary interventions per patient-year was observed, translating into significantly reduced costs per patient-year. To assess cost-effectiveness, costs and utilities of 1-year SoC were compared with those of 1-year Reducer-period. Assumptions on Reducer efficacy duration were further explored with modelled projections. Reducer was associated with higher quality-adjusted life years (QALYs: 0.665 vs. 0.580, P < 0.001) and incremental costs, yielding incremental cost-effectiveness ratios (ICERs) of 53 197, 34 948, 63 146 e/QALY gained in Belgium, the Netherlands, and Italy, respectively. Under both the assumptions of 2 and 3 years Reducer effect duration with a 30%-year efficacy decrease, the device yielded ICERs in the range of 1977–20 796 e/QALY gained. ................................................................................................................................................................................................... Conclusion In patients with RA, Reducer device decreases healthcare resource use and related costs. In a limited 1-year timeframe, Reducer is consistently cost-effective according to a range of cost-effectiveness thresholds. Under the explored assumptions, the device yields cost-effectiveness ratios suggesting high value from all the considered perspectives.

Original languageEnglish
Pages (from-to)32-40
Number of pages9
JournalEuropean heart journal. Quality of care & clinical outcomes
Volume6
Issue number1
Early online date24 May 2019
DOIs
Publication statusPublished - Jan 2020

Keywords

  • Chronic refractory angina
  • Coronary sinus Reducer
  • Cost-effectiveness
  • Healthcare costs
  • Quality of life

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