Cost-effectiveness of renal denervation therapy for the treatment of resistant hypertension in the Netherlands

Thea L. Henry*, Bonnie F E De Brouwer, Marjolijn M L Van Keep, Peter J. Blankestijn, Michiel L. Bots, Hendrik Koffijberg

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review



Safety and efficacy data for catheter-based renal denervation (RDN) in the treatment of resistant hypertension have been used to estimate the cost-effectiveness of this approach. However, there are no Dutch-specific analyses. This study examined the cost-effectiveness of RDN from the perspective of the healthcare payer in The Netherlands.


A previously constructed Markov state-transition model was adapted and updated with costs and utilities relevant to the Dutch setting. The cost-effectiveness of RDN was compared with standard of care (SoC) for patients with resistant hypertension. The efficacy of RDN treatment was modeled as a reduction in the risk of cardiovascular events associated with a lower systolic blood pressure (SBP).


Treatment with RDN compared to SoC gave an incremental quality-adjusted life year (QALY) gain of 0.89 at an additional cost of €1315 over a patient's lifetime, resulting in a base case incremental cost-effectiveness ratio (ICER) of €1474. Deterministic and probabilistic sensitivity analyses (PSA) showed that treatment with RDN therapy was cost-effective at conventional willingness-to-pay thresholds (€10,000-80,000/QALY).


RDN is a cost-effective intervention for patients with resistant hypertension in The Netherlands.

Original languageEnglish
Pages (from-to)76-87
Number of pages12
JournalJournal of Medical Economics
Issue number1
Publication statusPublished - 1 Jan 2015


  • Cardiovascular disease
  • Cost-effectiveness
  • Prevention
  • Renal sympathetic denervation
  • Resistant hypertension


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