TY - JOUR
T1 - Cortical microinfarcts on 3T MRI
T2 - Clinical correlates in memory-clinic patients
AU - Van Veluw, Susanne J.
AU - Hilal, Saima
AU - Kuijf, Hugo J.
AU - Ikram, Mohammad Kamran
AU - Xin, Xu
AU - Yeow, Tan Boon
AU - Venketasubramanian, Narayanaswamy
AU - Biessels, Geert Jan
AU - Chen, Christopher
PY - 2015/12/1
Y1 - 2015/12/1
N2 - Introduction This is the first study to assess cerebral microinfarcts (CMIs) on 3 tesla (3T) magnetic resonance imaging (MRI) in a memory clinic population. Methods We included 238 consecutive patients (aged 72.5 ± 9.1 years) from a memory clinic in Singapore. All patients underwent extensive neurological and neuropsychological testing and 3T MRI on the same day. Cortical CMI rating criteria were adapted from a previous study on 7T MRI. We analyzed the frequency and association of cortical CMIs with demographic, clinical, cognition, and other MRI findings. Results Seventy-five patients (32%) had cortical CMIs (median 1, range 1-43). Patients with CMIs showed worse cognitive functioning on MMSE, and in the domains of language and visuoconstruction. The presence of CMIs was related to other markers of small vessel disease, but most strongly larger cortical infarcts. Patients with CMIs were more often diagnosed with vascular dementia. Discussion Cortical CMIs on 3T MRI are a novel marker of cerebrovascular disease in dementia.
AB - Introduction This is the first study to assess cerebral microinfarcts (CMIs) on 3 tesla (3T) magnetic resonance imaging (MRI) in a memory clinic population. Methods We included 238 consecutive patients (aged 72.5 ± 9.1 years) from a memory clinic in Singapore. All patients underwent extensive neurological and neuropsychological testing and 3T MRI on the same day. Cortical CMI rating criteria were adapted from a previous study on 7T MRI. We analyzed the frequency and association of cortical CMIs with demographic, clinical, cognition, and other MRI findings. Results Seventy-five patients (32%) had cortical CMIs (median 1, range 1-43). Patients with CMIs showed worse cognitive functioning on MMSE, and in the domains of language and visuoconstruction. The presence of CMIs was related to other markers of small vessel disease, but most strongly larger cortical infarcts. Patients with CMIs were more often diagnosed with vascular dementia. Discussion Cortical CMIs on 3T MRI are a novel marker of cerebrovascular disease in dementia.
KW - Alzheimer's disease
KW - Atrophy
KW - Dementia
KW - Memory clinic population
KW - Microinfarcts
KW - MRI
KW - Small vessel disease
UR - http://www.scopus.com/inward/record.url?scp=84949481033&partnerID=8YFLogxK
U2 - 10.1016/j.jalz.2014.12.010
DO - 10.1016/j.jalz.2014.12.010
M3 - Article
AN - SCOPUS:84949481033
SN - 1552-5260
VL - 11
SP - 1500
EP - 1509
JO - Alzheimer's & Dementia
JF - Alzheimer's & Dementia
IS - 12
ER -