CORTICAL EXCITABILITY AS A POTENTIAL CLINICAL MARKER OF EPILEPSY: A REVIEW OF THE CLINICAL APPLICATION OF TRANSCRANIAL MAGNETIC STIMULATION

Prisca R. Bauer; Stiliyan Kalitzin; Maeike Zijlmans; Josemir W. Sander; Gerhard H. Visser

doi:10.1142/S0129065714300010

CORTICAL EXCITABILITY AS A POTENTIAL CLINICAL MARKER OF EPILEPSY: A REVIEW OF THE CLINICAL APPLICATION OF TRANSCRANIAL MAGNETIC STIMULATION

Prisca R. Bauer^*, Stiliyan Kalitzin, Maeike Zijlmans, Josemir W. Sander, Gerhard H. Visser

^*Corresponding author for this work

Research output: Contribution to journal › Literature review › peer-review

Abstract

Transcranial magnetic stimulation (TMS) can be used for safe, noninvasive probing of cortical excitability (CE). We review 50 studies that measured CE in people with epilepsy. Most showed cortical hyperexcitability, which can be corrected with anti-epileptic drug treatment. Several studies showed that decrease of CE after epilepsy surgery is predictive of good seizure outcome. CE is a potential biomarker for epilepsy. Clinical application may include outcome prediction of drug treatment and epilepsy surgery.

Original language	English
Article number	1430001
Number of pages	21
Journal	International Journal of Neural Systems
Volume	24
Issue number	2
DOIs	https://doi.org/10.1142/S0129065714300010
Publication status	Published - Mar 2014

Keywords

TMS
epilepsy
cortical excitability
TMS-EEG
HUMAN MOTOR CORTEX
JUVENILE MYOCLONIC EPILEPSY
IDIOPATHIC GENERALIZED EPILEPSIES
THRESHOLD TRACKING TECHNIQUES
MOBILE PHONE EMISSIONS
SILENT PERIOD
INTRACORTICAL INHIBITION
FOCAL EPILEPSY
BRAIN-STIMULATION
SLEEP-DEPRIVATION

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@article{6549ebbe282147449a56ad5fc8cb264f,

title = "CORTICAL EXCITABILITY AS A POTENTIAL CLINICAL MARKER OF EPILEPSY: A REVIEW OF THE CLINICAL APPLICATION OF TRANSCRANIAL MAGNETIC STIMULATION",

abstract = "Transcranial magnetic stimulation (TMS) can be used for safe, noninvasive probing of cortical excitability (CE). We review 50 studies that measured CE in people with epilepsy. Most showed cortical hyperexcitability, which can be corrected with anti-epileptic drug treatment. Several studies showed that decrease of CE after epilepsy surgery is predictive of good seizure outcome. CE is a potential biomarker for epilepsy. Clinical application may include outcome prediction of drug treatment and epilepsy surgery.",

keywords = "TMS, epilepsy, cortical excitability, TMS-EEG, HUMAN MOTOR CORTEX, JUVENILE MYOCLONIC EPILEPSY, IDIOPATHIC GENERALIZED EPILEPSIES, THRESHOLD TRACKING TECHNIQUES, MOBILE PHONE EMISSIONS, SILENT PERIOD, INTRACORTICAL INHIBITION, FOCAL EPILEPSY, BRAIN-STIMULATION, SLEEP-DEPRIVATION",

author = "Bauer, {Prisca R.} and Stiliyan Kalitzin and Maeike Zijlmans and Sander, {Josemir W.} and Visser, {Gerhard H.}",

year = "2014",

month = mar,

doi = "10.1142/S0129065714300010",

language = "English",

volume = "24",

journal = "International Journal of Neural Systems",

issn = "0129-0657",

publisher = "World Scientific Publishing",

number = "2",

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T1 - CORTICAL EXCITABILITY AS A POTENTIAL CLINICAL MARKER OF EPILEPSY

T2 - A REVIEW OF THE CLINICAL APPLICATION OF TRANSCRANIAL MAGNETIC STIMULATION

AU - Bauer, Prisca R.

AU - Kalitzin, Stiliyan

AU - Zijlmans, Maeike

AU - Sander, Josemir W.

AU - Visser, Gerhard H.

PY - 2014/3

Y1 - 2014/3

N2 - Transcranial magnetic stimulation (TMS) can be used for safe, noninvasive probing of cortical excitability (CE). We review 50 studies that measured CE in people with epilepsy. Most showed cortical hyperexcitability, which can be corrected with anti-epileptic drug treatment. Several studies showed that decrease of CE after epilepsy surgery is predictive of good seizure outcome. CE is a potential biomarker for epilepsy. Clinical application may include outcome prediction of drug treatment and epilepsy surgery.

AB - Transcranial magnetic stimulation (TMS) can be used for safe, noninvasive probing of cortical excitability (CE). We review 50 studies that measured CE in people with epilepsy. Most showed cortical hyperexcitability, which can be corrected with anti-epileptic drug treatment. Several studies showed that decrease of CE after epilepsy surgery is predictive of good seizure outcome. CE is a potential biomarker for epilepsy. Clinical application may include outcome prediction of drug treatment and epilepsy surgery.

KW - TMS

KW - epilepsy

KW - cortical excitability

KW - TMS-EEG

KW - HUMAN MOTOR CORTEX

KW - JUVENILE MYOCLONIC EPILEPSY

KW - IDIOPATHIC GENERALIZED EPILEPSIES

KW - THRESHOLD TRACKING TECHNIQUES

KW - MOBILE PHONE EMISSIONS

KW - SILENT PERIOD

KW - INTRACORTICAL INHIBITION

KW - FOCAL EPILEPSY

KW - BRAIN-STIMULATION

KW - SLEEP-DEPRIVATION

U2 - 10.1142/S0129065714300010

DO - 10.1142/S0129065714300010

M3 - Literature review

C2 - 24475894

SN - 0129-0657

VL - 24

JO - International Journal of Neural Systems

JF - International Journal of Neural Systems

IS - 2

M1 - 1430001

ER -

CORTICAL EXCITABILITY AS A POTENTIAL CLINICAL MARKER OF EPILEPSY: A REVIEW OF THE CLINICAL APPLICATION OF TRANSCRANIAL MAGNETIC STIMULATION

Abstract

Keywords

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