Coronary CT Angiography for Suspected ACS in the Era of High-Sensitivity Troponins Randomized Multicenter Study

Admir Dedic*, Marisa M. Lubbers, Jeroen Schaap, Jeronymus Lammers, Evert J. Lamfers, Benno J. Rensing, Richard L. Braam, Hendrik M. Nathoe, Johannes C. Post, Tim Nielen, Driek Beelen, Marie Claire Le Cocq D'Armandville, Pleunie P.M. Rood, Carl J. Schultz, Adriaan Moelker, Mohamed Ouhlous, Eric Boersma, Koen Nieman

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

24 Citations (Scopus)


Background It is uncertain whether a diagnostic strategy supplemented by early coronary computed tomography angiography (CCTA) is superior to contemporary standard optimal care (SOC) encompassing high-sensitivity troponin assays (hs-troponins) for patients suspected of acute coronary syndrome (ACS) in the emergency department (ED). Objectives This study assessed whether a diagnostic strategy supplemented by early CCTA improves clinical effectiveness compared with contemporary SOC. Methods In a prospective, open-label, multicenter, randomized trial, we enrolled patients presenting with symptoms suggestive of an ACS at the ED of 5 community and 2 university hospitals in the Netherlands. Exclusion criteria included the need for urgent cardiac catheterization and history of ACS or coronary revascularization. The primary endpoint was the number of patients identified with significant coronary artery disease requiring revascularization within 30 days. Results The study population consisted of 500 patients, of whom 236 (47%) were women (mean age 54 ± 10 years). There was no difference in the primary endpoint (22 [9%] patients underwent coronary revascularization within 30 days in the CCTA group and 17 [7%] in the SOC group [p = 0.40]). Discharge from the ED was not more frequent after CCTA (65% vs. 59%, p = 0.16), and length of stay was similar (6.3 h in both groups; p = 0.80). The CCTA group had lower direct medical costs (€337 vs. €511, p < 0.01) and less outpatient testing after the index ED visit (10 [4%] vs. 26 [10%], p < 0.01). There was no difference in incidence of undetected ACS. Conclusions CCTA, applied early in the work-up of suspected ACS, is safe and associated with less outpatient testing and lower costs. However, in the era of hs-troponins, CCTA does not identify more patients with significant CAD requiring coronary revascularization, shorten hospital stay, or allow for more direct discharge from the ED. (Better Evaluation of Acute Chest Pain with Computed Tomography Angiography [BEACON]; NCT01413282)

Original languageEnglish
Pages (from-to)16-26
Number of pages11
JournalJournal of the American College of Cardiology
Issue number1
Publication statusPublished - 5 Jan 2016


  • coronary artery disease
  • diagnosis
  • emergency department
  • Key Words chest pain


Dive into the research topics of 'Coronary CT Angiography for Suspected ACS in the Era of High-Sensitivity Troponins Randomized Multicenter Study'. Together they form a unique fingerprint.

Cite this