CONVINCE in the context of existing evidence on haemodiafiltration

doi:10.1093/ndt/gfac019

CONVINCE in the context of existing evidence on haemodiafiltration

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Abstract

Haemodiafiltration (HDF) provides a greater removal of larger solutes and protein-bound compounds than conventional high-flux haemodialysis (HD). There are indications that the patients receiving the highest convection volumes of HDF result in improved survival compared with HD. However, the comparative efficacy of HDF versus HD remains unproven. Here we provide a comparative account of the methodology and aims of 'the comparison of high-dose HDF with high-flux HD' (CONVINCE) study in the context of the totality of evidence and how this study will contribute to reaching a higher level of certainty regarding the comparative efficacy of HDF versus HD in people with end-stage kidney disease.

Original language	English
Pages (from-to)	1006-1013
Number of pages	8
Journal	Nephrol Dial Transplant
Volume	37
Issue number	6
DOIs	https://doi.org/10.1093/ndt/gfac019
Publication status	Published - 25 May 2022

Keywords

Convection
Hemodiafiltration/methods
Humans
Kidney Failure, Chronic/therapy
Renal Dialysis/methods

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10.1093/ndt/gfac019Licence: CC BY-NC

gfac019Final published version, 452 KBLicence: CC BY-NC

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title = "CONVINCE in the context of existing evidence on haemodiafiltration",

abstract = "Haemodiafiltration (HDF) provides a greater removal of larger solutes and protein-bound compounds than conventional high-flux haemodialysis (HD). There are indications that the patients receiving the highest convection volumes of HDF result in improved survival compared with HD. However, the comparative efficacy of HDF versus HD remains unproven. Here we provide a comparative account of the methodology and aims of 'the comparison of high-dose HDF with high-flux HD' (CONVINCE) study in the context of the totality of evidence and how this study will contribute to reaching a higher level of certainty regarding the comparative efficacy of HDF versus HD in people with end-stage kidney disease.",

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AU - Vernooij, Robin W M

AU - Bots, Michiel L

AU - Strippoli, Giovanni F M

AU - Canaud, Bernard

AU - Cromm, Krister

AU - Woodward, Mark

AU - Blankestijn, Peter J

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Y1 - 2022/5/25

N2 - Haemodiafiltration (HDF) provides a greater removal of larger solutes and protein-bound compounds than conventional high-flux haemodialysis (HD). There are indications that the patients receiving the highest convection volumes of HDF result in improved survival compared with HD. However, the comparative efficacy of HDF versus HD remains unproven. Here we provide a comparative account of the methodology and aims of 'the comparison of high-dose HDF with high-flux HD' (CONVINCE) study in the context of the totality of evidence and how this study will contribute to reaching a higher level of certainty regarding the comparative efficacy of HDF versus HD in people with end-stage kidney disease.

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KW - Hemodiafiltration/methods

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KW - Kidney Failure, Chronic/therapy

KW - Renal Dialysis/methods

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CONVINCE in the context of existing evidence on haemodiafiltration

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