CONVINCE in the context of existing evidence on haemodiafiltration

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Haemodiafiltration (HDF) provides a greater removal of larger solutes and protein-bound compounds than conventional high-flux haemodialysis (HD). There are indications that the patients receiving the highest convection volumes of HDF result in improved survival compared with HD. However, the comparative efficacy of HDF versus HD remains unproven. Here we provide a comparative account of the methodology and aims of 'the comparison of high-dose HDF with high-flux HD' (CONVINCE) study in the context of the totality of evidence and how this study will contribute to reaching a higher level of certainty regarding the comparative efficacy of HDF versus HD in people with end-stage kidney disease.

Original languageEnglish
Pages (from-to)1006-1013
Number of pages8
JournalNephrol Dial Transplant
Issue number6
Publication statusPublished - 25 May 2022


  • Convection
  • Hemodiafiltration/methods
  • Humans
  • Kidney Failure, Chronic/therapy
  • Renal Dialysis/methods


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