TY - JOUR
T1 - Controlling cellular plasticity to improve in vitro models for kidney regeneration
AU - Pou Casellas, Carla
AU - Rookmaaker, Maarten B.
AU - Verhaar, Marianne C.
N1 - Funding Information:
The authors acknowledge the support of the Gravitation Program ‘Materials Driven Regeneration,’ funded by the Netherlands Organization for Scientific Research (024.003.013) and of the partners of ‘Regenerative Medicine Crossing Borders’ (RegMed XB), powered by Health∼Holland , Top Sector Life Sciences and Health .
Publisher Copyright:
© 2021 The Author(s)
PY - 2021/12
Y1 - 2021/12
N2 - Given the increasing prevalence of end-stage kidney disease, the high morbidity and mortality of dialysis treatment, and the shortage of donor kidneys, the field of nephrology is progressively shifting its focus to regenerative medicine. In particular, both the development of a bioartificial kidney and the improvement of kidney-mimicking systems developed in vitro (e.g. organoids or tubuloids) for implantation purposes are attractive therapeutic strategies. However, a major hurdle to overcome with the current kidney cell models available is the limited control over cellular plasticity to augment cell-type-specific functionality. In this review, we summarize the main knowledge on important factors known to drive or affect maturation of kidney epithelial cells. This might aid in the advancement of in vitro kidney models to enable their use in regenerative medicine.
AB - Given the increasing prevalence of end-stage kidney disease, the high morbidity and mortality of dialysis treatment, and the shortage of donor kidneys, the field of nephrology is progressively shifting its focus to regenerative medicine. In particular, both the development of a bioartificial kidney and the improvement of kidney-mimicking systems developed in vitro (e.g. organoids or tubuloids) for implantation purposes are attractive therapeutic strategies. However, a major hurdle to overcome with the current kidney cell models available is the limited control over cellular plasticity to augment cell-type-specific functionality. In this review, we summarize the main knowledge on important factors known to drive or affect maturation of kidney epithelial cells. This might aid in the advancement of in vitro kidney models to enable their use in regenerative medicine.
KW - Cellular plasticity
KW - Kidney differentiation
KW - Kidney tubuloids
KW - Maturation factors
UR - https://www.scopus.com/pages/publications/85122806148
U2 - 10.1016/j.cobme.2021.100345
DO - 10.1016/j.cobme.2021.100345
M3 - Review article
AN - SCOPUS:85122806148
VL - 20
SP - 1
EP - 9
JO - Current opinion in biomedical engineering
JF - Current opinion in biomedical engineering
M1 - 100345
ER -