TY - JOUR
T1 - Controlled Release of RNAi Molecules by Tunable Supramolecular Hydrogel Carriers
AU - Bakker, Maarten H.
AU - van Rooij, Eva
AU - Dankers, Patricia Y.W.
PY - 2018/11/16
Y1 - 2018/11/16
N2 - Local, sustained release and presentation of RNAi therapeutics can be achieved with hydrogel delivery systems. Here we show the development of a supramolecular hydrogel into a local RNAi delivery system. By careful material design, two simple but effective strategies are introduced to obtain controlled release of two classes of RNAi therapeutics, that is, microRNA and antimiR. It was shown that the release of microRNA could be regulated using cholesterol-modification for interaction with the supramolecular hydrogel. Non-modified antimiR release could be controlled via supramolecular introduction of positively charged additive molecules into the supramolecular hydrogel. In this way, either the cholesterol-modification on the drug or the charge introduction into the hydrogel provides handles for controlled RNAi therapy.
AB - Local, sustained release and presentation of RNAi therapeutics can be achieved with hydrogel delivery systems. Here we show the development of a supramolecular hydrogel into a local RNAi delivery system. By careful material design, two simple but effective strategies are introduced to obtain controlled release of two classes of RNAi therapeutics, that is, microRNA and antimiR. It was shown that the release of microRNA could be regulated using cholesterol-modification for interaction with the supramolecular hydrogel. Non-modified antimiR release could be controlled via supramolecular introduction of positively charged additive molecules into the supramolecular hydrogel. In this way, either the cholesterol-modification on the drug or the charge introduction into the hydrogel provides handles for controlled RNAi therapy.
KW - affinity
KW - controlled release
KW - drug-delivery systems
KW - injectable
KW - RNAi
KW - supramolecular hydrogels
UR - http://www.scopus.com/inward/record.url?scp=85056593507&partnerID=8YFLogxK
U2 - 10.1002/asia.201800582
DO - 10.1002/asia.201800582
M3 - Article
C2 - 29858562
AN - SCOPUS:85056593507
SN - 1861-4728
VL - 13
SP - 3501
EP - 3508
JO - Chemistry - An Asian Journal
JF - Chemistry - An Asian Journal
IS - 22
ER -