TY - CHAP
T1 - Contributions of Wall Stretch and Shear Stress to Vascular Regulation
T2 - Molecular Mechanisms of Homeostasis and Expansion
AU - Maringanti, Ranganath
AU - Meijer, Elana
AU - Brandt, Maarten M.
AU - Duncker, Dirk J.
AU - Cheng, Caroline
N1 - Publisher Copyright:
© 2021, Springer Nature Switzerland AG.
PY - 2021/3/11
Y1 - 2021/3/11
N2 - Blood vessels are continuously exposed to hemodynamic forces due to the pulsatile nature of the blood flow. In normal physiological settings, these forces are essential in the maintenance of vascular cell function and structure, vascular growth, and in the regulation of vascular tone. However, when exceeding the physiological range these biomechanical forces become detrimental and may initiate pathological pathways. In this chapter, we discuss the types of vascular biomechanical forces, unravel cellular and molecular mechanisms underlying the physiological and pathophysiological response of the vascular cells to these biomechanical stimuli, and describe their role in triggering vascular growth.
AB - Blood vessels are continuously exposed to hemodynamic forces due to the pulsatile nature of the blood flow. In normal physiological settings, these forces are essential in the maintenance of vascular cell function and structure, vascular growth, and in the regulation of vascular tone. However, when exceeding the physiological range these biomechanical forces become detrimental and may initiate pathological pathways. In this chapter, we discuss the types of vascular biomechanical forces, unravel cellular and molecular mechanisms underlying the physiological and pathophysiological response of the vascular cells to these biomechanical stimuli, and describe their role in triggering vascular growth.
UR - http://www.scopus.com/inward/record.url?scp=85102499204&partnerID=8YFLogxK
U2 - 10.1007/978-3-030-63164-2_2
DO - 10.1007/978-3-030-63164-2_2
M3 - Chapter
AN - SCOPUS:85102499204
SN - 978-3-030-63163-5
T3 - Cardiac and Vascular Biology
SP - 21
EP - 46
BT - Cardiac and Vascular Biology
PB - Springer
ER -