TY - JOUR
T1 - Contribution of MSMB promoter region gene polymorphism to early-onset prostate cancer risk in Mexican males
AU - Trujillo-Cáceres, Silvia Juliana
AU - Torres-Sánchez, Luisa
AU - Burguete-García, Ana I.
AU - Orihuela, Yaneth Citlalli Orbe
AU - Vázquez-Salas, Ruth Argelia
AU - Álvarez-Topete, Esmeralda
AU - Gómez, Rocío
N1 - Funding Information:
This study received financial support from CONACyT 140482 and 272810.
Publisher Copyright:
Trujillo-Cáceres et al.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Sexually transmitted infections and its contribution to prostate cancer (PC) development have been relevant in different populations. MSMB gene polymorphism (rs10993994) has exhibited an association both with PC as well as the susceptibility to sexually transmitted infections. Hitherto, these conditions have been not studied in Mexico yet, neither if sexually transmitted infections could modify the MSMB and PC association. Herein, socio-demographic features, sexually transmitted infections records, the reproductive backgrounds, and the genetic characterisation were analysed in 322 incident PC cases and 628 population healthy controls from Mexico City. Whole PC, early-onset PC (PC at < 60 years old), late-onset PC (≥ 60 years old), and PC aggressiveness were used to evaluate the genetic variants contribution to PC risk using unconditional logistic regression models. Overall, none associations between the allelic variants of rs10993994 polymorphisms with whole and PC aggressiveness were found. Howbeit, the TT genotype carriers presented the highest susceptibility to develop early-onset PC (OR = 2.66; 95% CI = 1.41, 5.04; p = 0.03) than CC+CT carriers, both with codominant and recessive models. Although none association between whole PC and MSMB gene polymorphism was found, our results were reinforced by prior studies in European descendent populations, suggesting a contribution between rs10993994 and early-onset PC development.
AB - Sexually transmitted infections and its contribution to prostate cancer (PC) development have been relevant in different populations. MSMB gene polymorphism (rs10993994) has exhibited an association both with PC as well as the susceptibility to sexually transmitted infections. Hitherto, these conditions have been not studied in Mexico yet, neither if sexually transmitted infections could modify the MSMB and PC association. Herein, socio-demographic features, sexually transmitted infections records, the reproductive backgrounds, and the genetic characterisation were analysed in 322 incident PC cases and 628 population healthy controls from Mexico City. Whole PC, early-onset PC (PC at < 60 years old), late-onset PC (≥ 60 years old), and PC aggressiveness were used to evaluate the genetic variants contribution to PC risk using unconditional logistic regression models. Overall, none associations between the allelic variants of rs10993994 polymorphisms with whole and PC aggressiveness were found. Howbeit, the TT genotype carriers presented the highest susceptibility to develop early-onset PC (OR = 2.66; 95% CI = 1.41, 5.04; p = 0.03) than CC+CT carriers, both with codominant and recessive models. Although none association between whole PC and MSMB gene polymorphism was found, our results were reinforced by prior studies in European descendent populations, suggesting a contribution between rs10993994 and early-onset PC development.
KW - Genetic polymorphisms
KW - MSMB
KW - Prostate cancer
KW - Rs10993994
KW - Sexually transmitted diseases
UR - http://www.scopus.com/inward/record.url?scp=85060390954&partnerID=8YFLogxK
U2 - 10.18632/oncotarget.26592
DO - 10.18632/oncotarget.26592
M3 - Article
AN - SCOPUS:85060390954
SN - 1949-2553
VL - 10
SP - 738
EP - 748
JO - Oncotarget
JF - Oncotarget
IS - 7
ER -