Contrast harmonic intravascular ultrasound: a feasibility study for vasa vasorum imaging

David E Goertz; Martijn E Frijlink; Dennie Tempel; Luc C A van Damme; Robert Krams; Johannes A Schaar; Folkert J Ten Cate; Patrick W Serruys; Nico de Jong; Antonius F W van der Steen

doi:10.1097/01.rli.0000229773.11715.da

Contrast harmonic intravascular ultrasound: a feasibility study for vasa vasorum imaging

David E Goertz, Martijn E Frijlink, Dennie Tempel, Luc C A van Damme, Robert Krams, Johannes A Schaar, Folkert J Ten Cate, Patrick W Serruys, Nico de Jong, Antonius F W van der Steen

Department of Experimental Cardiology

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

OBJECTIVE: We sought to investigate feasibility of vasa vasorum imaging using the novel technique of contrast harmonic intravascular ultrasound.

METHODS: Prototype intravascular ultrasound (IVUS) instrumentation was developed for the sensitive detection of micro-bubble contrast agents. The technique, "harmonic" imaging, involves transmitting ultrasound at 20 MHz (fundamental) and detecting contrast signals at 40 MHz (second harmonic). Phantom experiments were conducted to investigate the detection of a small vessel in the wall surrounding a larger vessel. In vivo experiments were conducted in atherosclerotic rabbit abdominal aortas.

RESULTS: The phantom experiments showed improved small vessel detection in harmonic mode relative to fundamental mode. For the in vivo experiments, harmonic imaging enabled the visualization of contrast agent outside the aortic lumen through a statistically significant (P < 0.001) enhancement of image power, consistent with the detection of adventitial microvessels. These microvessels were not detected in fundamental imaging mode.

CONCLUSIONS: These results indicate the feasibility of contrast harmonic intravascular ultrasound as a new technique for vasa vasorum imaging.

Original language	English
Pages (from-to)	631-8
Number of pages	8
Journal	Investigative Radiology
Volume	41
Issue number	8
DOIs	https://doi.org/10.1097/01.rli.0000229773.11715.da
Publication status	Published - Aug 2006

Keywords

Animals
Aorta, Abdominal
Contrast Media
Coronary Artery Disease
Feasibility Studies
Fluorocarbons
Humans
Microbubbles
Neovascularization, Pathologic
Phantoms, Imaging
Rabbits
Ultrasonography, Interventional
Vasa Vasorum
Venae Cavae

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title = "Contrast harmonic intravascular ultrasound: a feasibility study for vasa vasorum imaging",

abstract = "OBJECTIVE: We sought to investigate feasibility of vasa vasorum imaging using the novel technique of contrast harmonic intravascular ultrasound.METHODS: Prototype intravascular ultrasound (IVUS) instrumentation was developed for the sensitive detection of micro-bubble contrast agents. The technique, {"}harmonic{"} imaging, involves transmitting ultrasound at 20 MHz (fundamental) and detecting contrast signals at 40 MHz (second harmonic). Phantom experiments were conducted to investigate the detection of a small vessel in the wall surrounding a larger vessel. In vivo experiments were conducted in atherosclerotic rabbit abdominal aortas.RESULTS: The phantom experiments showed improved small vessel detection in harmonic mode relative to fundamental mode. For the in vivo experiments, harmonic imaging enabled the visualization of contrast agent outside the aortic lumen through a statistically significant (P < 0.001) enhancement of image power, consistent with the detection of adventitial microvessels. These microvessels were not detected in fundamental imaging mode.CONCLUSIONS: These results indicate the feasibility of contrast harmonic intravascular ultrasound as a new technique for vasa vasorum imaging.",

keywords = "Animals, Aorta, Abdominal, Contrast Media, Coronary Artery Disease, Feasibility Studies, Fluorocarbons, Humans, Microbubbles, Neovascularization, Pathologic, Phantoms, Imaging, Rabbits, Ultrasonography, Interventional, Vasa Vasorum, Venae Cavae",

author = "Goertz, {David E} and Frijlink, {Martijn E} and Dennie Tempel and {van Damme}, {Luc C A} and Robert Krams and Schaar, {Johannes A} and {Ten Cate}, {Folkert J} and Serruys, {Patrick W} and {de Jong}, Nico and {van der Steen}, {Antonius F W}",

year = "2006",

month = aug,

doi = "10.1097/01.rli.0000229773.11715.da",

language = "English",

volume = "41",

pages = "631--8",

journal = "Investigative Radiology",

issn = "0020-9996",

publisher = "Lippincott Williams & Wilkins",

number = "8",

}

TY - JOUR

T1 - Contrast harmonic intravascular ultrasound

T2 - a feasibility study for vasa vasorum imaging

AU - Goertz, David E

AU - Frijlink, Martijn E

AU - Tempel, Dennie

AU - van Damme, Luc C A

AU - Krams, Robert

AU - Schaar, Johannes A

AU - Ten Cate, Folkert J

AU - Serruys, Patrick W

AU - de Jong, Nico

AU - van der Steen, Antonius F W

PY - 2006/8

Y1 - 2006/8

N2 - OBJECTIVE: We sought to investigate feasibility of vasa vasorum imaging using the novel technique of contrast harmonic intravascular ultrasound.METHODS: Prototype intravascular ultrasound (IVUS) instrumentation was developed for the sensitive detection of micro-bubble contrast agents. The technique, "harmonic" imaging, involves transmitting ultrasound at 20 MHz (fundamental) and detecting contrast signals at 40 MHz (second harmonic). Phantom experiments were conducted to investigate the detection of a small vessel in the wall surrounding a larger vessel. In vivo experiments were conducted in atherosclerotic rabbit abdominal aortas.RESULTS: The phantom experiments showed improved small vessel detection in harmonic mode relative to fundamental mode. For the in vivo experiments, harmonic imaging enabled the visualization of contrast agent outside the aortic lumen through a statistically significant (P < 0.001) enhancement of image power, consistent with the detection of adventitial microvessels. These microvessels were not detected in fundamental imaging mode.CONCLUSIONS: These results indicate the feasibility of contrast harmonic intravascular ultrasound as a new technique for vasa vasorum imaging.

AB - OBJECTIVE: We sought to investigate feasibility of vasa vasorum imaging using the novel technique of contrast harmonic intravascular ultrasound.METHODS: Prototype intravascular ultrasound (IVUS) instrumentation was developed for the sensitive detection of micro-bubble contrast agents. The technique, "harmonic" imaging, involves transmitting ultrasound at 20 MHz (fundamental) and detecting contrast signals at 40 MHz (second harmonic). Phantom experiments were conducted to investigate the detection of a small vessel in the wall surrounding a larger vessel. In vivo experiments were conducted in atherosclerotic rabbit abdominal aortas.RESULTS: The phantom experiments showed improved small vessel detection in harmonic mode relative to fundamental mode. For the in vivo experiments, harmonic imaging enabled the visualization of contrast agent outside the aortic lumen through a statistically significant (P < 0.001) enhancement of image power, consistent with the detection of adventitial microvessels. These microvessels were not detected in fundamental imaging mode.CONCLUSIONS: These results indicate the feasibility of contrast harmonic intravascular ultrasound as a new technique for vasa vasorum imaging.

KW - Animals

KW - Aorta, Abdominal

KW - Contrast Media

KW - Coronary Artery Disease

KW - Feasibility Studies

KW - Fluorocarbons

KW - Humans

KW - Microbubbles

KW - Neovascularization, Pathologic

KW - Phantoms, Imaging

KW - Rabbits

KW - Ultrasonography, Interventional

KW - Vasa Vasorum

KW - Venae Cavae

U2 - 10.1097/01.rli.0000229773.11715.da

DO - 10.1097/01.rli.0000229773.11715.da

M3 - Article

C2 - 16829746

SN - 0020-9996

VL - 41

SP - 631

EP - 638

JO - Investigative Radiology

JF - Investigative Radiology

IS - 8

ER -

Contrast harmonic intravascular ultrasound: a feasibility study for vasa vasorum imaging

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