Continuous intravenous infusion of enfuvirtide in a patient with a multidrug-resistant HIV strain

Robert W. Neijzen*, Erik M. van Maarseveen, Andy I M Hoepelman, Annemarie M J Wensing, Stefano Bonora, Antonio D’Avolio, Tania Mudrikova

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Case description To evaluate whether continuous intravenous (i.v.) administration of enfuvirtide (T20) could be a suitable alternative to subcutaneous (s.c.) administration of T20 in a patient with extensively drug-resistant HIV experiencing difficulties administering T20 subcutaneously. T20 was administered to a patient through 100 mL cassettes once daily via a CADD. Plasma samples were drawn and the pharmacokinetic profile compared to that of s.c. twice daily administration of T20. Also, viral replication and CD4+ count were monitored over a period of 9 months for this study. Continuous i.v. administration of T20 resulted in significantly higher T20 plasma levels compared to s.c. administration, continued viral suppression, a rise in CD4+ count and strong patient preference over s.c. administration. Conclusion This method of T20 administration may be a suitable alternative for selected patients who are not able to tolerate it when given subcutaneously. It may even be considered a priori in selected patients with extensive viral resistance who are unable or unwilling to inject T20 subcutaneously.

Original languageEnglish
Pages (from-to)749–751
Number of pages3
JournalInternational Journal of Clinical Pharmacy
Volume38
Issue number4
DOIs
Publication statusPublished - Aug 2016

Keywords

  • AIDS
  • Continuous intravenous therapy
  • Enfuvirtide
  • HIV
  • Resistance

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