Contemporary survival of adults with congenital heart disease

Teun van der Bom; Barbara Jm Mulder; Folkert Meijboom; Arie Pj van Dijk; Petronella G Pieper; Hubert W Vliegen; Thelma C Konings; Aeilko H Zwinderman; Berto J Bouma

doi:10.1136/heartjnl-2015-308144

Contemporary survival of adults with congenital heart disease

Teun van der Bom, Barbara Jm Mulder, Folkert Meijboom, Arie Pj van Dijk, Petronella G Pieper, Hubert W Vliegen, Thelma C Konings, Aeilko H Zwinderman, Berto J Bouma

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: Survival data that are applicable to the current population of adults with congenital heart disease (CHD) are not available.

OBJECTIVES: Using an alternative survival analysis with age as the primary time scale, we assessed the contemporary survival of adult patients with CHD.

METHODS: Survival was assessed using prospective data of the national registry of adult patients with CHD of the Netherlands. Survival was stratified by severity and lesion, and compared with a standardised general population.

RESULTS: Mean age at inclusion was 37 years, and 49% of the study population was male. During a cumulative prospective follow-up of 90 270 patient-years in 14 327 patients, 535 deaths occurred. Median survival was 53.4 (95% CI 49.9 to 60.7), 75.4 (95% CI 72.9 to 79.1) and 84.1 (95% CI 81.9 to 87.0) years for patients with severe, moderate and mild lesions, respectively. Survival of most patients with mild lesions did not differ from the general population, while, as expected, survival of patients with severe and moderate lesions was substantially lower (<0.001).

CONCLUSIONS: The present study gives insight in the contemporary survival of adults with CHD. This may aid patient counselling, timing of interventions and future research.

Original language	English
Pages (from-to)	1989-95
Number of pages	7
Journal	Heart
Volume	101
Issue number	24
DOIs	https://doi.org/10.1136/heartjnl-2015-308144
Publication status	Published - 15 Dec 2015

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@article{80eac7e614f845c0967c3f8c4f15ca2d,

title = "Contemporary survival of adults with congenital heart disease",

abstract = "BACKGROUND: Survival data that are applicable to the current population of adults with congenital heart disease (CHD) are not available.OBJECTIVES: Using an alternative survival analysis with age as the primary time scale, we assessed the contemporary survival of adult patients with CHD.METHODS: Survival was assessed using prospective data of the national registry of adult patients with CHD of the Netherlands. Survival was stratified by severity and lesion, and compared with a standardised general population.RESULTS: Mean age at inclusion was 37 years, and 49% of the study population was male. During a cumulative prospective follow-up of 90 270 patient-years in 14 327 patients, 535 deaths occurred. Median survival was 53.4 (95% CI 49.9 to 60.7), 75.4 (95% CI 72.9 to 79.1) and 84.1 (95% CI 81.9 to 87.0) years for patients with severe, moderate and mild lesions, respectively. Survival of most patients with mild lesions did not differ from the general population, while, as expected, survival of patients with severe and moderate lesions was substantially lower (<0.001).CONCLUSIONS: The present study gives insight in the contemporary survival of adults with CHD. This may aid patient counselling, timing of interventions and future research.",

author = "{van der Bom}, Teun and Mulder, {Barbara Jm} and Folkert Meijboom and {van Dijk}, {Arie Pj} and Pieper, {Petronella G} and Vliegen, {Hubert W} and Konings, {Thelma C} and Zwinderman, {Aeilko H} and Bouma, {Berto J}",

note = "Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/",

year = "2015",

month = dec,

day = "15",

doi = "10.1136/heartjnl-2015-308144",

language = "English",

volume = "101",

pages = "1989--95",

journal = "Heart",

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T1 - Contemporary survival of adults with congenital heart disease

AU - van der Bom, Teun

AU - Mulder, Barbara Jm

AU - Meijboom, Folkert

AU - van Dijk, Arie Pj

AU - Pieper, Petronella G

AU - Vliegen, Hubert W

AU - Konings, Thelma C

AU - Zwinderman, Aeilko H

AU - Bouma, Berto J

N1 - Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

PY - 2015/12/15

Y1 - 2015/12/15

N2 - BACKGROUND: Survival data that are applicable to the current population of adults with congenital heart disease (CHD) are not available.OBJECTIVES: Using an alternative survival analysis with age as the primary time scale, we assessed the contemporary survival of adult patients with CHD.METHODS: Survival was assessed using prospective data of the national registry of adult patients with CHD of the Netherlands. Survival was stratified by severity and lesion, and compared with a standardised general population.RESULTS: Mean age at inclusion was 37 years, and 49% of the study population was male. During a cumulative prospective follow-up of 90 270 patient-years in 14 327 patients, 535 deaths occurred. Median survival was 53.4 (95% CI 49.9 to 60.7), 75.4 (95% CI 72.9 to 79.1) and 84.1 (95% CI 81.9 to 87.0) years for patients with severe, moderate and mild lesions, respectively. Survival of most patients with mild lesions did not differ from the general population, while, as expected, survival of patients with severe and moderate lesions was substantially lower (<0.001).CONCLUSIONS: The present study gives insight in the contemporary survival of adults with CHD. This may aid patient counselling, timing of interventions and future research.

AB - BACKGROUND: Survival data that are applicable to the current population of adults with congenital heart disease (CHD) are not available.OBJECTIVES: Using an alternative survival analysis with age as the primary time scale, we assessed the contemporary survival of adult patients with CHD.METHODS: Survival was assessed using prospective data of the national registry of adult patients with CHD of the Netherlands. Survival was stratified by severity and lesion, and compared with a standardised general population.RESULTS: Mean age at inclusion was 37 years, and 49% of the study population was male. During a cumulative prospective follow-up of 90 270 patient-years in 14 327 patients, 535 deaths occurred. Median survival was 53.4 (95% CI 49.9 to 60.7), 75.4 (95% CI 72.9 to 79.1) and 84.1 (95% CI 81.9 to 87.0) years for patients with severe, moderate and mild lesions, respectively. Survival of most patients with mild lesions did not differ from the general population, while, as expected, survival of patients with severe and moderate lesions was substantially lower (<0.001).CONCLUSIONS: The present study gives insight in the contemporary survival of adults with CHD. This may aid patient counselling, timing of interventions and future research.

U2 - 10.1136/heartjnl-2015-308144

DO - 10.1136/heartjnl-2015-308144

M3 - Article

C2 - 26541168

SN - 1355-6037

VL - 101

SP - 1989

EP - 1995

JO - Heart

JF - Heart

IS - 24

ER -

Contemporary survival of adults with congenital heart disease

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