Contemporary management of the neck in nasopharyngeal carcinoma

Wai Tong Ng; Raymond K.Y. Tsang; Jonathan J. Beitler; Remco de Bree; Andrés Coca-Pelaz; Avraham Eisbruch; Orlando Guntinas-Lichius; Anne W.M. Lee; Antti A. Mäkitie; William M. Mendenhall; Sandra Nuyts; Alessandra Rinaldo; K. Thomas Robbins; Juan P. Rodrigo; Carl E. Silver; Ricard Simo; Robert Smee; Primož Strojan; Robert P. Takes; Alfio Ferlito

doi:10.1002/hed.26685

Contemporary management of the neck in nasopharyngeal carcinoma

Wai Tong Ng^*, Raymond K.Y. Tsang, Jonathan J. Beitler, Remco de Bree, Andrés Coca-Pelaz, Avraham Eisbruch, Orlando Guntinas-Lichius, Anne W.M. Lee, Antti A. Mäkitie, William M. Mendenhall, Sandra Nuyts, Alessandra Rinaldo, K. Thomas Robbins, Juan P. Rodrigo, Carl E. Silver, Ricard Simo, Robert Smee, Primož Strojan, Robert P. Takes, Alfio Ferlito

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

Up to 85% of the patients with nasopharyngeal carcinoma present with regional nodal metastasis. Although excellent nodal control is achieved with radiotherapy, a thorough understanding of the current TNM staging criteria and pattern of nodal spread is essential to optimize target delineation and minimize unnecessary irradiation to adjacent normal tissue. Selective nodal irradiation with sparing of the lower neck and submandibular region according to individual nodal risk is now emerging as the preferred treatment option. There has also been continual refinement in staging classification by incorporating relevant adverse nodal features. As for the uncommon occurrence of recurrent nodal metastasis after radiotherapy, surgery remains the standard of care.

Original language	English
Pages (from-to)	1949-1963
Number of pages	15
Journal	Head and Neck
Volume	43
Issue number	6
DOIs	https://doi.org/10.1002/hed.26685
Publication status	Published - Jun 2021

Keywords

nasopharyngeal carcinoma
nodal metastasis
prognosis
radiotherapy
staging
surgery
Carcinoma/therapy
Humans
Nasopharyngeal Carcinoma/radiotherapy
Neck/pathology
Lymphatic Metastasis
Neoplasm Staging
Nasopharyngeal Neoplasms/pathology

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10.1002/hed.26685

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Ng, W. T., Tsang, R. K. Y., Beitler, J. J., de Bree, R., Coca-Pelaz, A., Eisbruch, A., Guntinas-Lichius, O., Lee, A. W. M., Mäkitie, A. A., Mendenhall, W. M., Nuyts, S., Rinaldo, A., Robbins, K. T., Rodrigo, J. P., Silver, C. E., Simo, R., Smee, R., Strojan, P., Takes, R. P., & Ferlito, A. (2021). Contemporary management of the neck in nasopharyngeal carcinoma. Head and Neck, 43(6), 1949-1963. https://doi.org/10.1002/hed.26685

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title = "Contemporary management of the neck in nasopharyngeal carcinoma",

abstract = "Up to 85% of the patients with nasopharyngeal carcinoma present with regional nodal metastasis. Although excellent nodal control is achieved with radiotherapy, a thorough understanding of the current TNM staging criteria and pattern of nodal spread is essential to optimize target delineation and minimize unnecessary irradiation to adjacent normal tissue. Selective nodal irradiation with sparing of the lower neck and submandibular region according to individual nodal risk is now emerging as the preferred treatment option. There has also been continual refinement in staging classification by incorporating relevant adverse nodal features. As for the uncommon occurrence of recurrent nodal metastasis after radiotherapy, surgery remains the standard of care.",

keywords = "nasopharyngeal carcinoma, nodal metastasis, prognosis, radiotherapy, staging, surgery, Carcinoma/therapy, Humans, Nasopharyngeal Carcinoma/radiotherapy, Neck/pathology, Lymphatic Metastasis, Neoplasm Staging, Nasopharyngeal Neoplasms/pathology",

author = "Ng, {Wai Tong} and Tsang, {Raymond K.Y.} and Beitler, {Jonathan J.} and {de Bree}, Remco and Andr{\'e}s Coca-Pelaz and Avraham Eisbruch and Orlando Guntinas-Lichius and Lee, {Anne W.M.} and M{\"a}kitie, {Antti A.} and Mendenhall, {William M.} and Sandra Nuyts and Alessandra Rinaldo and Robbins, {K. Thomas} and Rodrigo, {Juan P.} and Silver, {Carl E.} and Ricard Simo and Robert Smee and Primo{\v z} Strojan and Takes, {Robert P.} and Alfio Ferlito",

note = "Publisher Copyright: {\textcopyright} 2021 Wiley Periodicals LLC.",

year = "2021",

month = jun,

doi = "10.1002/hed.26685",

language = "English",

volume = "43",

pages = "1949--1963",

journal = "Head and Neck",

issn = "1043-3074",

publisher = "John Wiley & Sons Inc.",

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Ng, WT, Tsang, RKY, Beitler, JJ, de Bree, R, Coca-Pelaz, A, Eisbruch, A, Guntinas-Lichius, O, Lee, AWM, Mäkitie, AA, Mendenhall, WM, Nuyts, S, Rinaldo, A, Robbins, KT, Rodrigo, JP, Silver, CE, Simo, R, Smee, R, Strojan, P, Takes, RP & Ferlito, A 2021, 'Contemporary management of the neck in nasopharyngeal carcinoma', Head and Neck, vol. 43, no. 6, pp. 1949-1963. https://doi.org/10.1002/hed.26685

TY - JOUR

T1 - Contemporary management of the neck in nasopharyngeal carcinoma

AU - Ng, Wai Tong

AU - Tsang, Raymond K.Y.

AU - Beitler, Jonathan J.

AU - de Bree, Remco

AU - Coca-Pelaz, Andrés

AU - Eisbruch, Avraham

AU - Guntinas-Lichius, Orlando

AU - Lee, Anne W.M.

AU - Mäkitie, Antti A.

AU - Mendenhall, William M.

AU - Nuyts, Sandra

AU - Rinaldo, Alessandra

AU - Robbins, K. Thomas

AU - Rodrigo, Juan P.

AU - Silver, Carl E.

AU - Simo, Ricard

AU - Smee, Robert

AU - Strojan, Primož

AU - Takes, Robert P.

AU - Ferlito, Alfio

PY - 2021/6

Y1 - 2021/6

N2 - Up to 85% of the patients with nasopharyngeal carcinoma present with regional nodal metastasis. Although excellent nodal control is achieved with radiotherapy, a thorough understanding of the current TNM staging criteria and pattern of nodal spread is essential to optimize target delineation and minimize unnecessary irradiation to adjacent normal tissue. Selective nodal irradiation with sparing of the lower neck and submandibular region according to individual nodal risk is now emerging as the preferred treatment option. There has also been continual refinement in staging classification by incorporating relevant adverse nodal features. As for the uncommon occurrence of recurrent nodal metastasis after radiotherapy, surgery remains the standard of care.

AB - Up to 85% of the patients with nasopharyngeal carcinoma present with regional nodal metastasis. Although excellent nodal control is achieved with radiotherapy, a thorough understanding of the current TNM staging criteria and pattern of nodal spread is essential to optimize target delineation and minimize unnecessary irradiation to adjacent normal tissue. Selective nodal irradiation with sparing of the lower neck and submandibular region according to individual nodal risk is now emerging as the preferred treatment option. There has also been continual refinement in staging classification by incorporating relevant adverse nodal features. As for the uncommon occurrence of recurrent nodal metastasis after radiotherapy, surgery remains the standard of care.

KW - nasopharyngeal carcinoma

KW - nodal metastasis

KW - prognosis

KW - radiotherapy

KW - staging

KW - surgery

KW - Carcinoma/therapy

KW - Humans

KW - Nasopharyngeal Carcinoma/radiotherapy

KW - Neck/pathology

KW - Lymphatic Metastasis

KW - Neoplasm Staging

KW - Nasopharyngeal Neoplasms/pathology

UR - http://www.scopus.com/inward/record.url?scp=85103399274&partnerID=8YFLogxK

U2 - 10.1002/hed.26685

DO - 10.1002/hed.26685

M3 - Review article

C2 - 33780074

AN - SCOPUS:85103399274

SN - 1043-3074

VL - 43

SP - 1949

EP - 1963

JO - Head and Neck

JF - Head and Neck

IS - 6

ER -

Contemporary management of the neck in nasopharyngeal carcinoma

Abstract

Keywords

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