Consequences of IgE/CD23-mediated antigen presentation in allergy

G.C. Mudde; R. Bheeka; C.A.F.M. Bruijnzeel - Koomen

doi:10.1016/0167-5699(95)80005-0

Consequences of IgE/CD23-mediated antigen presentation in allergy

G.C. Mudde, R. Bheeka, C.A.F.M. Bruijnzeel - Koomen

Dermatology and Allergology

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Allergen-specific IgE antibodies are responsible for the generation of immediate-type hypersensitivity reactions. However, as described here by Geert Mudde, Roy Bheekha and Carla Bruijnzeel-Koomen, IgE may also be involved in the uptake and processing of allergens. Such IgE-mediated antigen presentation may lead to a continuous (over) activation of the immune system due to high titers of IgE and the presence of large numbers of allergen-specific Th2 cells. In addition, it may be a cause for the advance of disease from a 'single allergy' to 'multi-allergy' syndrome.

Original language	English
Pages (from-to)	380-383
Number of pages	4
Journal	Immunology Today
Volume	16
Issue number	8
DOIs	https://doi.org/10.1016/0167-5699(95)80005-0
Publication status	Published - Aug 1995

Keywords

Allergens
Animals
Antibody Formation
Antigen Presentation
Humans
Hypersensitivity, Immediate
Immunoglobulin Class Switching
Immunoglobulin E
Lymphocyte Activation
Lymphocyte Cooperation
Mice
Models, Immunological
Receptors, IgE

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title = "Consequences of IgE/CD23-mediated antigen presentation in allergy",

abstract = "Allergen-specific IgE antibodies are responsible for the generation of immediate-type hypersensitivity reactions. However, as described here by Geert Mudde, Roy Bheekha and Carla Bruijnzeel-Koomen, IgE may also be involved in the uptake and processing of allergens. Such IgE-mediated antigen presentation may lead to a continuous (over) activation of the immune system due to high titers of IgE and the presence of large numbers of allergen-specific Th2 cells. In addition, it may be a cause for the advance of disease from a 'single allergy' to 'multi-allergy' syndrome.",

keywords = "Allergens, Animals, Antibody Formation, Antigen Presentation, Humans, Hypersensitivity, Immediate, Immunoglobulin Class Switching, Immunoglobulin E, Lymphocyte Activation, Lymphocyte Cooperation, Mice, Models, Immunological, Receptors, IgE",

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T1 - Consequences of IgE/CD23-mediated antigen presentation in allergy

AU - Mudde, G.C.

AU - Bheeka, R.

AU - Bruijnzeel - Koomen, C.A.F.M.

N1 - keypublication

PY - 1995/8

Y1 - 1995/8

N2 - Allergen-specific IgE antibodies are responsible for the generation of immediate-type hypersensitivity reactions. However, as described here by Geert Mudde, Roy Bheekha and Carla Bruijnzeel-Koomen, IgE may also be involved in the uptake and processing of allergens. Such IgE-mediated antigen presentation may lead to a continuous (over) activation of the immune system due to high titers of IgE and the presence of large numbers of allergen-specific Th2 cells. In addition, it may be a cause for the advance of disease from a 'single allergy' to 'multi-allergy' syndrome.

AB - Allergen-specific IgE antibodies are responsible for the generation of immediate-type hypersensitivity reactions. However, as described here by Geert Mudde, Roy Bheekha and Carla Bruijnzeel-Koomen, IgE may also be involved in the uptake and processing of allergens. Such IgE-mediated antigen presentation may lead to a continuous (over) activation of the immune system due to high titers of IgE and the presence of large numbers of allergen-specific Th2 cells. In addition, it may be a cause for the advance of disease from a 'single allergy' to 'multi-allergy' syndrome.

KW - Allergens

KW - Animals

KW - Antibody Formation

KW - Antigen Presentation

KW - Humans

KW - Hypersensitivity, Immediate

KW - Immunoglobulin Class Switching

KW - Immunoglobulin E

KW - Lymphocyte Activation

KW - Lymphocyte Cooperation

KW - Mice

KW - Models, Immunological

KW - Receptors, IgE

U2 - 10.1016/0167-5699(95)80005-0

DO - 10.1016/0167-5699(95)80005-0

M3 - Article

C2 - 7546193

SN - 0167-5699

VL - 16

SP - 380

EP - 383

JO - Immunology Today

JF - Immunology Today

IS - 8

ER -

Consequences of IgE/CD23-mediated antigen presentation in allergy

Abstract

Keywords

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