Consequences of diagnosing a tumor predisposition syndrome in children with cancer: A literature review

Floor A M Postema; Saskia M.J. Hopman; Raoul C M Hennekam; Johannes H.M. Merks

doi:10.1002/pbc.26718

Consequences of diagnosing a tumor predisposition syndrome in children with cancer: A literature review

Floor A M Postema
, Saskia M.J. Hopman
, Raoul C M Hennekam
, Johannes H.M. Merks^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

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Abstract

Up to 8.5% of children with cancer have a genetic cause for their cancer: a tumor predisposition syndrome (TPS). Diagnosing a TPS is of great importance, as it may have major consequences for clinical care. Patients with TPSs require specific monitoring and management. We present an overview of the cancer-related and noncancer-related consequences for the 36 most common TPSs.

Original language	English
Article number	e26718
Journal	Pediatric Blood & Cancer
Volume	65
Issue number	1
DOIs	https://doi.org/10.1002/pbc.26718
Publication status	Published - 1 Jan 2018

Keywords

cancer
consequences
genetic predisposition to disease
pediatrics

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10.1002/pbc.26718

Postema_et_al-2018-Pediatric_Blood_%26_CancerFinal published version, 245 KBLicence: Taverne

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title = "Consequences of diagnosing a tumor predisposition syndrome in children with cancer: A literature review",

abstract = "Up to 8.5\% of children with cancer have a genetic cause for their cancer: a tumor predisposition syndrome (TPS). Diagnosing a TPS is of great importance, as it may have major consequences for clinical care. Patients with TPSs require specific monitoring and management. We present an overview of the cancer-related and noncancer-related consequences for the 36 most common TPSs.",

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AU - Hennekam, Raoul C M

AU - Merks, Johannes H.M.

PY - 2018/1/1

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N2 - Up to 8.5% of children with cancer have a genetic cause for their cancer: a tumor predisposition syndrome (TPS). Diagnosing a TPS is of great importance, as it may have major consequences for clinical care. Patients with TPSs require specific monitoring and management. We present an overview of the cancer-related and noncancer-related consequences for the 36 most common TPSs.

AB - Up to 8.5% of children with cancer have a genetic cause for their cancer: a tumor predisposition syndrome (TPS). Diagnosing a TPS is of great importance, as it may have major consequences for clinical care. Patients with TPSs require specific monitoring and management. We present an overview of the cancer-related and noncancer-related consequences for the 36 most common TPSs.

KW - cancer

KW - consequences

KW - genetic predisposition to disease

KW - pediatrics

UR - https://www.scopus.com/pages/publications/85035017689

U2 - 10.1002/pbc.26718

DO - 10.1002/pbc.26718

M3 - Review article

AN - SCOPUS:85035017689

SN - 1545-5009

VL - 65

JO - Pediatric Blood & Cancer

JF - Pediatric Blood & Cancer

IS - 1

M1 - e26718

ER -

Consequences of diagnosing a tumor predisposition syndrome in children with cancer: A literature review

Abstract

Keywords

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