Consensus Paper: Experimental Neurostimulation of the Cerebellum

Lauren N Miterko; Kenneth B Baker; Jaclyn Beckinghausen; Lynley V Bradnam; Michelle Y Cheng; Jessica Cooperrider; Mahlon R DeLong; Simona V Gornati; Mark Hallett; Detlef H Heck; Freek E Hoebeek; Abbas Z Kouzani; Sheng-Han Kuo; Elan D Louis; Andre Machado; Mario Manto; Alana B McCambridge; Michael A Nitsche; Nordeyn Oulad Ben Taib; Traian Popa; Masaki Tanaka; Dagmar Timmann; Gary K Steinberg; Eric H Wang; Thomas Wichmann; Tao Xie; Roy V Sillitoe

doi:10.1007/s12311-019-01041-5

Consensus Paper: Experimental Neurostimulation of the Cerebellum

Lauren N Miterko, Kenneth B Baker, Jaclyn Beckinghausen, Lynley V Bradnam, Michelle Y Cheng, Jessica Cooperrider, Mahlon R DeLong, Simona V Gornati, Mark Hallett, Detlef H Heck, Freek E Hoebeek, Abbas Z Kouzani, Sheng-Han Kuo, Elan D Louis, Andre Machado, Mario Manto, Alana B McCambridge, Michael A Nitsche, Nordeyn Oulad Ben Taib, Traian PopaMasaki Tanaka, Dagmar Timmann, Gary K Steinberg, Eric H Wang, Thomas Wichmann, Tao Xie, Roy V Sillitoe

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Abstract

The cerebellum is best known for its role in controlling motor behaviors. However, recent work supports the view that it also influences non-motor behaviors. The contribution of the cerebellum towards different brain functions is underscored by its involvement in a diverse and increasing number of neurological and neuropsychiatric conditions including ataxia, dystonia, essential tremor, Parkinson's disease (PD), epilepsy, stroke, multiple sclerosis, autism spectrum disorders, dyslexia, attention deficit hyperactivity disorder (ADHD), and schizophrenia. Although there are no cures for these conditions, cerebellar stimulation is quickly gaining attention for symptomatic alleviation, as cerebellar circuitry has arisen as a promising target for invasive and non-invasive neuromodulation. This consensus paper brings together experts from the fields of neurophysiology, neurology, and neurosurgery to discuss recent efforts in using the cerebellum as a therapeutic intervention. We report on the most advanced techniques for manipulating cerebellar circuits in humans and animal models and define key hurdles and questions for moving forward.

Original language	English
Pages (from-to)	1064-1097
Number of pages	34
Journal	Cerebellum (London, England)
Volume	18
Issue number	6
DOIs	https://doi.org/10.1007/s12311-019-01041-5
Publication status	Published - Dec 2019

Keywords

Cerebellum
DBS
Neuromodulation
Neurostimulation
Non-invasive therapy
Optogenetics

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Miterko, L. N., Baker, K. B., Beckinghausen, J., Bradnam, L. V., Cheng, M. Y., Cooperrider, J., DeLong, M. R., Gornati, S. V., Hallett, M., Heck, D. H., Hoebeek, F. E., Kouzani, A. Z., Kuo, S.-H., Louis, E. D., Machado, A., Manto, M., McCambridge, A. B., Nitsche, M. A., Taib, N. O. B., ... Sillitoe, R. V. (2019). Consensus Paper: Experimental Neurostimulation of the Cerebellum. Cerebellum (London, England), 18(6), 1064-1097. https://doi.org/10.1007/s12311-019-01041-5

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title = "Consensus Paper: Experimental Neurostimulation of the Cerebellum",

abstract = "The cerebellum is best known for its role in controlling motor behaviors. However, recent work supports the view that it also influences non-motor behaviors. The contribution of the cerebellum towards different brain functions is underscored by its involvement in a diverse and increasing number of neurological and neuropsychiatric conditions including ataxia, dystonia, essential tremor, Parkinson's disease (PD), epilepsy, stroke, multiple sclerosis, autism spectrum disorders, dyslexia, attention deficit hyperactivity disorder (ADHD), and schizophrenia. Although there are no cures for these conditions, cerebellar stimulation is quickly gaining attention for symptomatic alleviation, as cerebellar circuitry has arisen as a promising target for invasive and non-invasive neuromodulation. This consensus paper brings together experts from the fields of neurophysiology, neurology, and neurosurgery to discuss recent efforts in using the cerebellum as a therapeutic intervention. We report on the most advanced techniques for manipulating cerebellar circuits in humans and animal models and define key hurdles and questions for moving forward.",

keywords = "Cerebellum, DBS, Neuromodulation, Neurostimulation, Non-invasive therapy, Optogenetics",

author = "Miterko, {Lauren N} and Baker, {Kenneth B} and Jaclyn Beckinghausen and Bradnam, {Lynley V} and Cheng, {Michelle Y} and Jessica Cooperrider and DeLong, {Mahlon R} and Gornati, {Simona V} and Mark Hallett and Heck, {Detlef H} and Hoebeek, {Freek E} and Kouzani, {Abbas Z} and Sheng-Han Kuo and Louis, {Elan D} and Andre Machado and Mario Manto and McCambridge, {Alana B} and Nitsche, {Michael A} and Taib, {Nordeyn Oulad Ben} and Traian Popa and Masaki Tanaka and Dagmar Timmann and Steinberg, {Gary K} and Wang, {Eric H} and Thomas Wichmann and Tao Xie and Sillitoe, {Roy V}",

note = "Publisher Copyright: {\textcopyright} 2019, The Author(s).",

year = "2019",

month = dec,

doi = "10.1007/s12311-019-01041-5",

language = "English",

volume = "18",

pages = "1064--1097",

number = "6",

}

Miterko, LN, Baker, KB, Beckinghausen, J, Bradnam, LV, Cheng, MY, Cooperrider, J, DeLong, MR, Gornati, SV, Hallett, M, Heck, DH, Hoebeek, FE, Kouzani, AZ, Kuo, S-H, Louis, ED, Machado, A, Manto, M, McCambridge, AB, Nitsche, MA, Taib, NOB, Popa, T, Tanaka, M, Timmann, D, Steinberg, GK, Wang, EH, Wichmann, T, Xie, T & Sillitoe, RV 2019, 'Consensus Paper: Experimental Neurostimulation of the Cerebellum', Cerebellum (London, England), vol. 18, no. 6, pp. 1064-1097. https://doi.org/10.1007/s12311-019-01041-5

TY - JOUR

T1 - Consensus Paper

T2 - Experimental Neurostimulation of the Cerebellum

AU - Miterko, Lauren N

AU - Baker, Kenneth B

AU - Beckinghausen, Jaclyn

AU - Bradnam, Lynley V

AU - Cheng, Michelle Y

AU - Cooperrider, Jessica

AU - DeLong, Mahlon R

AU - Gornati, Simona V

AU - Hallett, Mark

AU - Heck, Detlef H

AU - Hoebeek, Freek E

AU - Kouzani, Abbas Z

AU - Kuo, Sheng-Han

AU - Louis, Elan D

AU - Machado, Andre

AU - Manto, Mario

AU - McCambridge, Alana B

AU - Nitsche, Michael A

AU - Taib, Nordeyn Oulad Ben

AU - Popa, Traian

AU - Tanaka, Masaki

AU - Timmann, Dagmar

AU - Steinberg, Gary K

AU - Wang, Eric H

AU - Wichmann, Thomas

AU - Xie, Tao

AU - Sillitoe, Roy V

PY - 2019/12

Y1 - 2019/12

N2 - The cerebellum is best known for its role in controlling motor behaviors. However, recent work supports the view that it also influences non-motor behaviors. The contribution of the cerebellum towards different brain functions is underscored by its involvement in a diverse and increasing number of neurological and neuropsychiatric conditions including ataxia, dystonia, essential tremor, Parkinson's disease (PD), epilepsy, stroke, multiple sclerosis, autism spectrum disorders, dyslexia, attention deficit hyperactivity disorder (ADHD), and schizophrenia. Although there are no cures for these conditions, cerebellar stimulation is quickly gaining attention for symptomatic alleviation, as cerebellar circuitry has arisen as a promising target for invasive and non-invasive neuromodulation. This consensus paper brings together experts from the fields of neurophysiology, neurology, and neurosurgery to discuss recent efforts in using the cerebellum as a therapeutic intervention. We report on the most advanced techniques for manipulating cerebellar circuits in humans and animal models and define key hurdles and questions for moving forward.

AB - The cerebellum is best known for its role in controlling motor behaviors. However, recent work supports the view that it also influences non-motor behaviors. The contribution of the cerebellum towards different brain functions is underscored by its involvement in a diverse and increasing number of neurological and neuropsychiatric conditions including ataxia, dystonia, essential tremor, Parkinson's disease (PD), epilepsy, stroke, multiple sclerosis, autism spectrum disorders, dyslexia, attention deficit hyperactivity disorder (ADHD), and schizophrenia. Although there are no cures for these conditions, cerebellar stimulation is quickly gaining attention for symptomatic alleviation, as cerebellar circuitry has arisen as a promising target for invasive and non-invasive neuromodulation. This consensus paper brings together experts from the fields of neurophysiology, neurology, and neurosurgery to discuss recent efforts in using the cerebellum as a therapeutic intervention. We report on the most advanced techniques for manipulating cerebellar circuits in humans and animal models and define key hurdles and questions for moving forward.

KW - Cerebellum

KW - DBS

KW - Neuromodulation

KW - Neurostimulation

KW - Non-invasive therapy

KW - Optogenetics

UR - http://www.scopus.com/inward/record.url?scp=85067246896&partnerID=8YFLogxK

U2 - 10.1007/s12311-019-01041-5

DO - 10.1007/s12311-019-01041-5

M3 - Review article

C2 - 31165428

SN - 1473-4222

VL - 18

SP - 1064

EP - 1097

JO - Cerebellum (London, England)

JF - Cerebellum (London, England)

IS - 6

ER -

Consensus Paper: Experimental Neurostimulation of the Cerebellum

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