TY - JOUR
T1 - Consensus-based technical recommendations for clinical translation of renal diffusion-weighted MRI
AU - Ljimani, Alexandra
AU - Caroli, Anna
AU - Laustsen, Christoffer
AU - Francis, Susan
AU - Mendichovszky, Iosif Alexandru
AU - Bane, Octavia
AU - Nery, Fabio
AU - Sharma, Kanishka
AU - Pohlmann, Andreas
AU - Dekkers, Ilona A
AU - Vallee, Jean-Paul
AU - Derlin, Katja
AU - Notohamiprodjo, Mike
AU - Lim, Ruth P
AU - Palmucci, Stefano
AU - Serai, Suraj D
AU - Periquito, Joao
AU - Wang, Zhen Jane
AU - Froeling, Martijn
AU - Thoeny, Harriet C
AU - Prasad, Pottumarthi
AU - Schneider, Moritz
AU - Niendorf, Thoralf
AU - Pullens, Pim
AU - Sourbron, Steven
AU - Sigmund, Eric E
N1 - Funding Information:
The article is based upon work from COST Action Magnetic Resonance Imaging Biomarkers for Chronic Kidney Disease (PARENCHIMA, COST Action CA16103, www.renalmri.org ), funded by COST (European Cooperation in Science and Technology), www.cost.eu . For additional information please visit PARENCHIMA project website: www.renalmri.org . MIA funding from the Medical Research Council (Grant No. MR/R02264X/1). BO Grant support (2016-2018) from NIH NIDDK individual fellowship 1F32DK109591. SK was supported by the Biomarker Enterprise to Attack Diabetic Kidney Disease project funded by the Innovative Medicines Initiative 2 Joint Undertaking under Grant agreement 115974. This joint undertaking received support from the European Union’s Horizon 2020 Research and Innovation programme and European Federation of Pharmaceutical Industries and Associations. PA receives funding from the German Research Council (DFG; Collaborative Research Centre SFB 1365 Renoprotection). J-PV and THC are supported by the Swiss National Science foundation Nb: IZCOZ0_177140/1. DK, NM, SEE research collaboration with Siemens. LRP Grant funding from Boehringer-Ingelheim. PJ receives funding from the German Ministry for Education and Research (BMBF; Grant VIP 03P00081). NT is supported by Germany Research Foundation, Collaborative Research Center 1365.
Publisher Copyright:
© 2019, The Author(s).
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/2/1
Y1 - 2020/2/1
N2 - OBJECTIVES: Standardization is an important milestone in the validation of DWI-based parameters as imaging biomarkers for renal disease. Here, we propose technical recommendations on three variants of renal DWI, monoexponential DWI, IVIM and DTI, as well as associated MRI biomarkers (ADC, D, D*, f, FA and MD) to aid ongoing international efforts on methodological harmonization.MATERIALS AND METHODS: Reported DWI biomarkers from 194 prior renal DWI studies were extracted and Pearson correlations between diffusion biomarkers and protocol parameters were computed. Based on the literature review, surveys were designed for the consensus building. Survey data were collected via Delphi consensus process on renal DWI preparation, acquisition, analysis, and reporting. Consensus was defined as ≥ 75% agreement.RESULTS: Correlations were observed between reported diffusion biomarkers and protocol parameters. Out of 87 survey questions, 57 achieved consensus resolution, while many of the remaining questions were resolved by preference (65-74% agreement). Summary of the literature and survey data as well as recommendations for the preparation, acquisition, processing and reporting of renal DWI were provided.DISCUSSION: The consensus-based technical recommendations for renal DWI aim to facilitate inter-site harmonization and increase clinical impact of the technique on a larger scale by setting a framework for acquisition protocols for future renal DWI studies. We anticipate an iterative process with continuous updating of the recommendations according to progress in the field.
AB - OBJECTIVES: Standardization is an important milestone in the validation of DWI-based parameters as imaging biomarkers for renal disease. Here, we propose technical recommendations on three variants of renal DWI, monoexponential DWI, IVIM and DTI, as well as associated MRI biomarkers (ADC, D, D*, f, FA and MD) to aid ongoing international efforts on methodological harmonization.MATERIALS AND METHODS: Reported DWI biomarkers from 194 prior renal DWI studies were extracted and Pearson correlations between diffusion biomarkers and protocol parameters were computed. Based on the literature review, surveys were designed for the consensus building. Survey data were collected via Delphi consensus process on renal DWI preparation, acquisition, analysis, and reporting. Consensus was defined as ≥ 75% agreement.RESULTS: Correlations were observed between reported diffusion biomarkers and protocol parameters. Out of 87 survey questions, 57 achieved consensus resolution, while many of the remaining questions were resolved by preference (65-74% agreement). Summary of the literature and survey data as well as recommendations for the preparation, acquisition, processing and reporting of renal DWI were provided.DISCUSSION: The consensus-based technical recommendations for renal DWI aim to facilitate inter-site harmonization and increase clinical impact of the technique on a larger scale by setting a framework for acquisition protocols for future renal DWI studies. We anticipate an iterative process with continuous updating of the recommendations according to progress in the field.
KW - Biomarker
KW - DWI
KW - ADC
KW - IVIM
KW - DTI
UR - https://www.scopus.com/pages/publications/85074722687
U2 - 10.1007/s10334-019-00790-y
DO - 10.1007/s10334-019-00790-y
M3 - Article
C2 - 31676990
SN - 0968-5243
VL - 33
SP - 177
EP - 195
JO - Magma - Magnetic Resonance Materials In Physics Biology And Medicine
JF - Magma - Magnetic Resonance Materials In Physics Biology And Medicine
IS - 1
ER -