Consensus-based technical recommendations for clinical translation of renal T1 and T2 mapping MRI

Ilona A Dekkers, Anneloes de Boer, Kaniska Sharma, Eleanor F Cox, Hildo J Lamb, David L Buckley, Octavia Bane, David M Morris, Pottumarthi V Prasad, Scott I K Semple, Keith A Gillis, Paul Hockings, Charlotte Buchanan, Marcos Wolf, Christoffer Laustsen, Tim Leiner, Bryan Haddock, Johannes M Hoogduin, Pim Pullens, Steven SourbronSusan Francis

Research output: Contribution to journalReview articlepeer-review


To develop technical recommendations on the acquisition and post-processing of renal longitudinal (T1) and transverse (T2) relaxation time mapping. A multidisciplinary panel consisting of 18 experts in the field of renal T1 and T2 mapping participated in a consensus project, which was initiated by the European Cooperation in Science and Technology Action PARENCHIMA CA16103. Consensus recommendations were formulated using a two-step modified Delphi method. The first survey consisted of 56 items on T1 mapping, of which 4 reached the pre-defined consensus threshold of 75% or higher. The second survey was expanded to include both T1 and T2 mapping, and consisted of 54 items of which 32 reached consensus. Recommendations based were formulated on hardware, patient preparation, acquisition, analysis and reporting. Consensus-based technical recommendations for renal T1 and T2 mapping were formulated. However, there was considerable lack of consensus for renal T1 and particularly renal T2 mapping, to some extent surprising considering the long history of relaxometry in MRI, highlighting key knowledge gaps that require further work. This paper should be regarded as a first step in a long-term evidence-based iterative process towards ever increasing harmonization of scan protocols across sites, to ultimately facilitate clinical implementation.

Original languageEnglish
Pages (from-to)163-176
Number of pages14
JournalMagma: Magnetic Resonance Materials in Physics, Biology, and Medicine
Issue number1
Early online date22 Nov 2019
Publication statusPublished - Feb 2020


  • Biomarkers
  • Consensus
  • Kidney
  • MRI
  • Standardization
  • T1 relaxation
  • T2 relaxation


Dive into the research topics of 'Consensus-based technical recommendations for clinical translation of renal T1 and T2 mapping MRI'. Together they form a unique fingerprint.

Cite this