TY - JOUR
T1 - Connective tissue growth factor (CTGF) from basics to clinics
AU - Ramazani, Yasaman
AU - Knops, Noël
AU - Elmonem, Mohamed A.
AU - Nguyen, Tri Q.
AU - Arcolino, Fanny Oliveira
AU - van den Heuvel, Lambert
AU - Levtchenko, Elena
AU - Kuypers, Dirk
AU - Goldschmeding, Roel
N1 - Funding Information:
YR was supported by strategic basic Fonds Wetenschappelijk Onderzoek (FWO) [grant number 1S24417N ].
Funding Information:
YR was supported by strategic basic Fonds Wetenschappelijk Onderzoek (FWO) [grant number 1S24417N].
Publisher Copyright:
© 2018 Elsevier B.V.
PY - 2018/8/1
Y1 - 2018/8/1
N2 - Connective tissue growth factor, also known as CCN2, is a cysteine-rich matricellular protein involved in the control of biological processes, such as cell proliferation, differentiation, adhesion and angiogenesis, as well as multiple pathologies, such as tumor development and tissue fibrosis. Here, we describe the molecular and biological characteristics of CTGF, its regulation and various functions in the spectrum of development and regeneration to fibrosis. We further outline the preclinical and clinical studies concerning compounds targeting CTGF in various pathologies with the focus on heart, lung, liver, kidney and solid organ transplantation. Finally, we address the advances and pitfalls of translational fibrosis research and provide suggestions to move towards a better management of fibrosis.
AB - Connective tissue growth factor, also known as CCN2, is a cysteine-rich matricellular protein involved in the control of biological processes, such as cell proliferation, differentiation, adhesion and angiogenesis, as well as multiple pathologies, such as tumor development and tissue fibrosis. Here, we describe the molecular and biological characteristics of CTGF, its regulation and various functions in the spectrum of development and regeneration to fibrosis. We further outline the preclinical and clinical studies concerning compounds targeting CTGF in various pathologies with the focus on heart, lung, liver, kidney and solid organ transplantation. Finally, we address the advances and pitfalls of translational fibrosis research and provide suggestions to move towards a better management of fibrosis.
KW - CCN2
KW - Connective tissue growth factor
KW - Fibrosis
KW - Marker and therapeutic target
KW - Matricellular protein
UR - http://www.scopus.com/inward/record.url?scp=85045840516&partnerID=8YFLogxK
U2 - 10.1016/j.matbio.2018.03.007
DO - 10.1016/j.matbio.2018.03.007
M3 - Review article
AN - SCOPUS:85045840516
SN - 0945-053X
VL - 68-69
SP - 44
EP - 66
JO - Matrix Biology
JF - Matrix Biology
ER -