Congenital dermatoglyphic malformations in severe bipolar disorder

Blanca Gutiérrez; Jim Van Os; Vicenç Vallès; Roser Guillamat; Maite Campillo; Lourdes Fañanás

doi:10.1016/S0165-1781(98)00016-X

Congenital dermatoglyphic malformations in severe bipolar disorder

Blanca Gutiérrez, Jim Van Os, Vicenç Vallès, Roser Guillamat, Maite Campillo, Lourdes Fañanás^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

35 Citations (Scopus)

Abstract

Dermatoglyphic alterations may be the result of early prenatal disturbances thought to be implicated in the aetiology of psychiatric illness. In order to tat this hypothesis in the particular case of bipolar disorder, we assessed two congenital dermatoglyphic malformations (ridge dissociation (RD) and abnormal features (AF)) and two metric dermatoglyphic traits (total finger ridge count (TFRC) and total a-b ridge count (TABRC)) in a sample of 118 patients with chronic DSM-III-R bipolar illness, and 216 healthy controls. Bipolar cases showed a significant excess of RD and AF (OR = 2.80; 95% CI: 2.31-3.38) when compared with controls. In the cases, the presence of anomalies was associated with earlier age of onset. No differences were found for TFRC and TABRC. No associations were found with sex or familial morbid risk of psychiatric disorders. Our findings add further weight to the suggestion that early developmental disruption is a risk factor for later bipolar disorder.

Original language	English
Pages (from-to)	133-140
Number of pages	8
Journal	Psychiatry Research
Volume	78
Issue number	3
DOIs	https://doi.org/10.1016/S0165-1781(98)00016-X
Publication status	Published - 8 May 1998
Externally published	Yes

Keywords

Affective disorder
Family history
Manic-depressive illness
Prenatal complications
Risk factors

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title = "Congenital dermatoglyphic malformations in severe bipolar disorder",

abstract = "Dermatoglyphic alterations may be the result of early prenatal disturbances thought to be implicated in the aetiology of psychiatric illness. In order to tat this hypothesis in the particular case of bipolar disorder, we assessed two congenital dermatoglyphic malformations (ridge dissociation (RD) and abnormal features (AF)) and two metric dermatoglyphic traits (total finger ridge count (TFRC) and total a-b ridge count (TABRC)) in a sample of 118 patients with chronic DSM-III-R bipolar illness, and 216 healthy controls. Bipolar cases showed a significant excess of RD and AF (OR = 2.80; 95\% CI: 2.31-3.38) when compared with controls. In the cases, the presence of anomalies was associated with earlier age of onset. No differences were found for TFRC and TABRC. No associations were found with sex or familial morbid risk of psychiatric disorders. Our findings add further weight to the suggestion that early developmental disruption is a risk factor for later bipolar disorder.",

keywords = "Affective disorder, Family history, Manic-depressive illness, Prenatal complications, Risk factors",

author = "Blanca Guti{\'e}rrez and \{Van Os\}, Jim and Vicen{\c c} Vall{\`e}s and Roser Guillamat and Maite Campillo and Lourdes Fa{\~n}an{\'a}s",

note = "Funding Information: Blanca Guti{\'e}rrez was awarded a PhD grant by `Vice-rectorat de Recerca' (Universitat de Barcelona). This work was supported by a grant from the Spanish `Ministerio de Educaci{\'o}n y Ciencia' (project 91B/1996-97) and The British Council to Lourdes Fa{\~n}an{\'a}s and Jim Van Os. The authors thank Dr. Jaume Bertranpetit and `Comissionat per a Universitats i Recerca' (1996SGR 00041) for his help. ",

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AU - Gutiérrez, Blanca

AU - Van Os, Jim

AU - Vallès, Vicenç

AU - Guillamat, Roser

AU - Campillo, Maite

AU - Fañanás, Lourdes

N1 - Funding Information: Blanca Gutiérrez was awarded a PhD grant by `Vice-rectorat de Recerca' (Universitat de Barcelona). This work was supported by a grant from the Spanish `Ministerio de Educación y Ciencia' (project 91B/1996-97) and The British Council to Lourdes Fañanás and Jim Van Os. The authors thank Dr. Jaume Bertranpetit and `Comissionat per a Universitats i Recerca' (1996SGR 00041) for his help.

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N2 - Dermatoglyphic alterations may be the result of early prenatal disturbances thought to be implicated in the aetiology of psychiatric illness. In order to tat this hypothesis in the particular case of bipolar disorder, we assessed two congenital dermatoglyphic malformations (ridge dissociation (RD) and abnormal features (AF)) and two metric dermatoglyphic traits (total finger ridge count (TFRC) and total a-b ridge count (TABRC)) in a sample of 118 patients with chronic DSM-III-R bipolar illness, and 216 healthy controls. Bipolar cases showed a significant excess of RD and AF (OR = 2.80; 95% CI: 2.31-3.38) when compared with controls. In the cases, the presence of anomalies was associated with earlier age of onset. No differences were found for TFRC and TABRC. No associations were found with sex or familial morbid risk of psychiatric disorders. Our findings add further weight to the suggestion that early developmental disruption is a risk factor for later bipolar disorder.

AB - Dermatoglyphic alterations may be the result of early prenatal disturbances thought to be implicated in the aetiology of psychiatric illness. In order to tat this hypothesis in the particular case of bipolar disorder, we assessed two congenital dermatoglyphic malformations (ridge dissociation (RD) and abnormal features (AF)) and two metric dermatoglyphic traits (total finger ridge count (TFRC) and total a-b ridge count (TABRC)) in a sample of 118 patients with chronic DSM-III-R bipolar illness, and 216 healthy controls. Bipolar cases showed a significant excess of RD and AF (OR = 2.80; 95% CI: 2.31-3.38) when compared with controls. In the cases, the presence of anomalies was associated with earlier age of onset. No differences were found for TFRC and TABRC. No associations were found with sex or familial morbid risk of psychiatric disorders. Our findings add further weight to the suggestion that early developmental disruption is a risk factor for later bipolar disorder.

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KW - Family history

KW - Manic-depressive illness

KW - Prenatal complications

KW - Risk factors

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Congenital dermatoglyphic malformations in severe bipolar disorder

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Keywords

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