TY - JOUR
T1 - Confirmation of a metastasis-specific microRNA signature in primary colon cancer
AU - Coebergh Van Den Braak, Robert R.J.
AU - Sieuwerts, Anieta M.
AU - Lalmahomed, Zarina S.
AU - Smid, Marcel
AU - Wilting, Saskia M.
AU - Bril, Sandra I.
AU - Xiang, Shanshan
AU - Van Der Vlugt-Daane, Michelle
AU - De Weerd, Vanja
AU - Van Galen, Anne
AU - Biermann, Katharina
AU - Van Krieken, J. Han J.M.
AU - Kloosterman, Wigard P.
AU - Foekens, John A.
AU - Martens, John W.M.
AU - Ijzermans, Jan N.M.
AU - Coene, Peter Paul L.O.
AU - Dekker, Jan Willem T.
AU - Zimmerman, David D.E.
AU - Tetteroo, Geert W.M.
AU - Vles, Wouter J.
AU - Vrijland, Wietske W.
N1 - Funding Information:
This work was supported by the MLDS, Dutch Digestive Foundation (grant number FP 13-20); the NutsOhra Foundation (grant number 0903-011); and the Dutch Cancer Society (KWF) (grant number UU 2012-5710). JF was funded through an ERC Advanced Grant (ERC-20120AdG-322737). AS and JM were supported by Cancer Genomics Netherlands (CGC.nl) funded by the Netherlands Organisation for Scientific Research (NWO).
Publisher Copyright:
© 2018 The Author(s).
PY - 2018/12/1
Y1 - 2018/12/1
N2 - The identification of patients with high-risk stage II colon cancer who may benefit from adjuvant therapy may allow the clinical approach to be tailored for these patients based on an understanding of tumour biology. MicroRNAs have been proposed as markers of the prognosis or treatment response in colorectal cancer. Recently, a 2-microRNA signature (l et-7i and miR-10b) was proposed to identify colorectal cancer patients at risk of developing distant metastasis. We assessed the prognostic value of this signature and additional candidate microRNAs in an independent, clinically well-defined, prospectively collected cohort of primary colon cancer patients including stage I-II colon cancer without and stage III colon cancer with adjuvant treatment. The 2-microRNA signature specifically predicted hepatic recurrence in the stage I-II group, but not the overall ability to develop distant metastasis. The addition of miR-30b to the 2-microRNA signature allowed the prediction of both distant metastasis and hepatic recurrence in patients with stage I-II colon cancer who did not receive adjuvant chemotherapy. Available gene expression data allowed us to associate m iR-30b expression with axon guidance and l et-7i expression with cell adhesion, migration, and motility.
AB - The identification of patients with high-risk stage II colon cancer who may benefit from adjuvant therapy may allow the clinical approach to be tailored for these patients based on an understanding of tumour biology. MicroRNAs have been proposed as markers of the prognosis or treatment response in colorectal cancer. Recently, a 2-microRNA signature (l et-7i and miR-10b) was proposed to identify colorectal cancer patients at risk of developing distant metastasis. We assessed the prognostic value of this signature and additional candidate microRNAs in an independent, clinically well-defined, prospectively collected cohort of primary colon cancer patients including stage I-II colon cancer without and stage III colon cancer with adjuvant treatment. The 2-microRNA signature specifically predicted hepatic recurrence in the stage I-II group, but not the overall ability to develop distant metastasis. The addition of miR-30b to the 2-microRNA signature allowed the prediction of both distant metastasis and hepatic recurrence in patients with stage I-II colon cancer who did not receive adjuvant chemotherapy. Available gene expression data allowed us to associate m iR-30b expression with axon guidance and l et-7i expression with cell adhesion, migration, and motility.
UR - http://www.scopus.com/inward/record.url?scp=85044570013&partnerID=8YFLogxK
U2 - 10.1038/s41598-018-22532-1
DO - 10.1038/s41598-018-22532-1
M3 - Article
AN - SCOPUS:85044570013
SN - 2045-2322
VL - 8
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 5242
ER -