Concise review: Developing best-practice models for the therapeutic use of extracellular vesicles

Agnes T. Reiner, Kenneth W. Witwer, Bas W.M. Van Balkom, Joel De Beer, Chaya Brodie, Randolph L. Corteling, Susanne Gabrielsson, Mario Gimona, Ahmed G. Ibrahim, Dominique De Kleijn, Charles P. Lai, Jan Lo Tvall, Hernando A Del Portillo, Ilona G Reischl, Milad Riazifar, Carlos Salomon, Hidetoshi Tahara, Wei Seong Toh, Marca H M Wauben, Vicky K. YangYijun Yang, Ronne Wee Yeh Yeo, Hang Yin, Bernd Giebel, Eva Rohde*, Sai Kiang Lim

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Growing interest in extracellular vesicles (EVs, including exosomes and microvesicles) as therapeutic entities, particularly in stem cell-related approaches, has underlined the need for standardization and coordination of development efforts. Members of the International Society for Extracellular Vesicles and the Society for Clinical Research and Translation of Extracellular Vesicles Singapore convened a Workshop on this topic to discuss the opportunities and challenges associated with development of EV-based therapeutics at the preclinical and clinical levels. This review outlines topic-specific action items that, if addressed, will enhance the development of bestpractice models for EV therapies.

Original languageEnglish
Pages (from-to)1730-1739
Number of pages10
JournalStem Cells Translational Medicine
Issue number8
Publication statusPublished - 1 Aug 2017


  • Cellular therapy
  • Clinical translation
  • Clinical trials
  • Exosomes
  • Extracellular vesicles
  • Microvesicles
  • Stem cells
  • Therapeutics


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