Concentrations of nitrogen mustard in the air during topical treatment of patients with mycosis fungoides

W. A. Van Vloten; A. C M Cooijmans; J. Poel; J. Meulenbelt

Concentrations of nitrogen mustard in the air during topical treatment of patients with mycosis fungoides

W. A. Van Vloten^*, A. C M Cooijmans, J. Poel, J. Meulenbelt

^*Corresponding author for this work

Clinical Toxicology

Research output: Contribution to journal › Article › Academic › peer-review

6 Citations (Scopus)

Abstract

Acute and chronic side-effects have been reported during topical treatment of mycosis fungoides with nitrogen mustard (HN2). In order to estimate the risk for the nurse applying topical NH2, the concentration of HN2 in the air during treatment was measured. Air samples were obtained before, and during the 20-min treatment period close to the nurse and patient, and continuously at a distance of 1 m from the patient. The mean concentration of HN2 in the air during treatment was 0.036 mg/m³. Immediately after treatment the concentration dropped to 0.004 mg/m³. The mean cumulative concentration in the room during the 3 1/2 h of the experiment was 0.012 mg/m³. If the MAC (maximal allowable concentration) value of 0.05 mg/m³ for the comparable sulphur mustard is used as a guideline, then with a treatment procedure of 20 min this level is not exceeded. Nevertheless, it is important to minimize the exposure of nursing staff to HN2.

Original language	English
Pages (from-to)	404-406
Number of pages	3
Journal	British Journal of Dermatology
Volume	128
Issue number	4
Publication status	Published - 1 Jan 1993

Cite this

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title = "Concentrations of nitrogen mustard in the air during topical treatment of patients with mycosis fungoides",

abstract = "Acute and chronic side-effects have been reported during topical treatment of mycosis fungoides with nitrogen mustard (HN2). In order to estimate the risk for the nurse applying topical NH2, the concentration of HN2 in the air during treatment was measured. Air samples were obtained before, and during the 20-min treatment period close to the nurse and patient, and continuously at a distance of 1 m from the patient. The mean concentration of HN2 in the air during treatment was 0.036 mg/m3. Immediately after treatment the concentration dropped to 0.004 mg/m3. The mean cumulative concentration in the room during the 3 1/2 h of the experiment was 0.012 mg/m3. If the MAC (maximal allowable concentration) value of 0.05 mg/m3 for the comparable sulphur mustard is used as a guideline, then with a treatment procedure of 20 min this level is not exceeded. Nevertheless, it is important to minimize the exposure of nursing staff to HN2.",

author = "{Van Vloten}, {W. A.} and Cooijmans, {A. C M} and J. Poel and J. Meulenbelt",

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AU - Van Vloten, W. A.

AU - Cooijmans, A. C M

AU - Poel, J.

AU - Meulenbelt, J.

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N2 - Acute and chronic side-effects have been reported during topical treatment of mycosis fungoides with nitrogen mustard (HN2). In order to estimate the risk for the nurse applying topical NH2, the concentration of HN2 in the air during treatment was measured. Air samples were obtained before, and during the 20-min treatment period close to the nurse and patient, and continuously at a distance of 1 m from the patient. The mean concentration of HN2 in the air during treatment was 0.036 mg/m3. Immediately after treatment the concentration dropped to 0.004 mg/m3. The mean cumulative concentration in the room during the 3 1/2 h of the experiment was 0.012 mg/m3. If the MAC (maximal allowable concentration) value of 0.05 mg/m3 for the comparable sulphur mustard is used as a guideline, then with a treatment procedure of 20 min this level is not exceeded. Nevertheless, it is important to minimize the exposure of nursing staff to HN2.

AB - Acute and chronic side-effects have been reported during topical treatment of mycosis fungoides with nitrogen mustard (HN2). In order to estimate the risk for the nurse applying topical NH2, the concentration of HN2 in the air during treatment was measured. Air samples were obtained before, and during the 20-min treatment period close to the nurse and patient, and continuously at a distance of 1 m from the patient. The mean concentration of HN2 in the air during treatment was 0.036 mg/m3. Immediately after treatment the concentration dropped to 0.004 mg/m3. The mean cumulative concentration in the room during the 3 1/2 h of the experiment was 0.012 mg/m3. If the MAC (maximal allowable concentration) value of 0.05 mg/m3 for the comparable sulphur mustard is used as a guideline, then with a treatment procedure of 20 min this level is not exceeded. Nevertheless, it is important to minimize the exposure of nursing staff to HN2.

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Concentrations of nitrogen mustard in the air during topical treatment of patients with mycosis fungoides

Abstract

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