COMT Val158met genotype and striatal D2/3 receptor binding in adults with 22q11 deletion syndrome

Erik Boot; Jan Booij; Janneke R. Zinkstok; Frank Baas; Ann Swillen; Michael J. Owen; Declan G. Murphy; Kieran C. Murphy; Don H. Linszen; Thérèse A. Van Amelsvoort

doi:10.1002/syn.20932

COMT Val¹⁵⁸met genotype and striatal D_2/3 receptor binding in adults with 22q11 deletion syndrome

Erik Boot^*, Jan Booij, Janneke R. Zinkstok, Frank Baas, Ann Swillen, Michael J. Owen, Declan G. Murphy, Kieran C. Murphy, Don H. Linszen, Thérèse A. Van Amelsvoort

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

11 Citations (Scopus)

Abstract

Although catechol-O-methyltransferase (COMT) activity evidently affects dopamine function in prefrontal cortex, the contribution is assumed less significant in striatum. We studied whether a functional polymorphism in the COMT gene (Val¹⁵⁸Met) influences striatal D_2/3R binding ratios (D_2/3R BP_ND) in 15 adults with 22q11 deletion syndrome and hemizygous for this gene, using single photon emission computed tomography and the selective D_2/3 radioligand [¹²³I]IBZM. Met hemizygotes had significantly lower mean D_2/3R BPND than Val hemizygotes. These preliminary data suggest that low COMT activity may affect dopamine levels in striatum in humans and this may have implications for understanding the contribution of COMT activity to psychiatric disorders.

Original language	English
Pages (from-to)	967-970
Number of pages	4
Journal	Synapse
Volume	65
Issue number	9
DOIs	https://doi.org/10.1002/syn.20932
Publication status	Published - 1 Sept 2011
Externally published	Yes

Keywords

Catechol-O-methyltransferase
D receptor binding
Dopamine
SPECT
Striatum

Access to Document

10.1002/syn.20932

Cite this

@article{a1c62af174e14272b307486304dadcb8,

title = "COMT Val158met genotype and striatal D2/3 receptor binding in adults with 22q11 deletion syndrome",

abstract = "Although catechol-O-methyltransferase (COMT) activity evidently affects dopamine function in prefrontal cortex, the contribution is assumed less significant in striatum. We studied whether a functional polymorphism in the COMT gene (Val158Met) influences striatal D2/3R binding ratios (D2/3R BPND) in 15 adults with 22q11 deletion syndrome and hemizygous for this gene, using single photon emission computed tomography and the selective D2/3 radioligand [123I]IBZM. Met hemizygotes had significantly lower mean D2/3R BPND than Val hemizygotes. These preliminary data suggest that low COMT activity may affect dopamine levels in striatum in humans and this may have implications for understanding the contribution of COMT activity to psychiatric disorders.",

keywords = "Catechol-O-methyltransferase, D receptor binding, Dopamine, SPECT, Striatum",

author = "Erik Boot and Jan Booij and Zinkstok, {Janneke R.} and Frank Baas and Ann Swillen and Owen, {Michael J.} and Murphy, {Declan G.} and Murphy, {Kieran C.} and Linszen, {Don H.} and {Van Amelsvoort}, {Th{\'e}r{\`e}se A.}",

year = "2011",

month = sep,

day = "1",

doi = "10.1002/syn.20932",

language = "English",

volume = "65",

pages = "967--970",

number = "9",

}

TY - JOUR

T1 - COMT Val158met genotype and striatal D2/3 receptor binding in adults with 22q11 deletion syndrome

AU - Boot, Erik

AU - Booij, Jan

AU - Zinkstok, Janneke R.

AU - Baas, Frank

AU - Swillen, Ann

AU - Owen, Michael J.

AU - Murphy, Declan G.

AU - Murphy, Kieran C.

AU - Linszen, Don H.

AU - Van Amelsvoort, Thérèse A.

PY - 2011/9/1

Y1 - 2011/9/1

N2 - Although catechol-O-methyltransferase (COMT) activity evidently affects dopamine function in prefrontal cortex, the contribution is assumed less significant in striatum. We studied whether a functional polymorphism in the COMT gene (Val158Met) influences striatal D2/3R binding ratios (D2/3R BPND) in 15 adults with 22q11 deletion syndrome and hemizygous for this gene, using single photon emission computed tomography and the selective D2/3 radioligand [123I]IBZM. Met hemizygotes had significantly lower mean D2/3R BPND than Val hemizygotes. These preliminary data suggest that low COMT activity may affect dopamine levels in striatum in humans and this may have implications for understanding the contribution of COMT activity to psychiatric disorders.

AB - Although catechol-O-methyltransferase (COMT) activity evidently affects dopamine function in prefrontal cortex, the contribution is assumed less significant in striatum. We studied whether a functional polymorphism in the COMT gene (Val158Met) influences striatal D2/3R binding ratios (D2/3R BPND) in 15 adults with 22q11 deletion syndrome and hemizygous for this gene, using single photon emission computed tomography and the selective D2/3 radioligand [123I]IBZM. Met hemizygotes had significantly lower mean D2/3R BPND than Val hemizygotes. These preliminary data suggest that low COMT activity may affect dopamine levels in striatum in humans and this may have implications for understanding the contribution of COMT activity to psychiatric disorders.

KW - Catechol-O-methyltransferase

KW - D receptor binding

KW - Dopamine

KW - SPECT

KW - Striatum

UR - http://www.scopus.com/inward/record.url?scp=79959946393&partnerID=8YFLogxK

U2 - 10.1002/syn.20932

DO - 10.1002/syn.20932

M3 - Article

C2 - 21465565

AN - SCOPUS:79959946393

SN - 0887-4476

VL - 65

SP - 967

EP - 970

JO - Synapse

JF - Synapse

IS - 9

ER -

COMT Val¹⁵⁸met genotype and striatal D_2/3 receptor binding in adults with 22q11 deletion syndrome

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this