TY - JOUR
T1 - Computed Tomography Screening for Early Lung Cancer, COPD and Cardiovascular Disease in Shanghai
T2 - Rationale and Design of a Population-based Comparative Study
AU - Du, Yihui
AU - Li, Qiong
AU - Sidorenkov, Grigory
AU - Vonder, Marleen
AU - Cai, Jiali
AU - de Bock, Geertruida H
AU - Guan, Yu
AU - Xia, Yi
AU - Zhou, Xiuxiu
AU - Zhang, Di
AU - Rook, Mieneke
AU - Vliegenthart, Rozemarijn
AU - Heuvelmans, Marjolein A
AU - Dorrius, Monique D
AU - van Ooijen, P M A
AU - Groen, Harry J M
AU - van der Harst, Pim
AU - Xiao, Yi
AU - Ye, Zhaoxiang
AU - Xie, Xueqian
AU - Wang, Wenjing
AU - Oudkerk, Matthijs
AU - Fan, Li
AU - Liu, Shiyuan
N1 - Publisher Copyright:
© 2020 The Association of University Radiologists
PY - 2021/1
Y1 - 2021/1
N2 - RATIONALE AND OBJECTIVES: To describe the rational and design of a population-based comparative study. The objective of the study is to assess the screening performance of volume-based management of CT-detected lung nodule in comparison to diameter-based management, and to improve the effectiveness of CT screening for chronic obstructive pulmonary disease (COPD) and cardiovascular disease (CVD), in addition to lung cancer, based on quantitative measurement of CT imaging biomarkers in a Chinese screening setting.MATERIALS AND METHODS: A population-based comparative study is being performed, including 10,000 asymptomatic participants between 40 and 74 years old from Shanghai urban population. Participants in the intervention group undergo a low-dose chest and cardiac CT scan at baseline and 1 year later, and are managed according to NELCIN-B3 protocol. Participants in the control group undergo a low-dose chest CT scan according to the routine CT protocol and are managed according to the clinical practice. Epidemiological data are collected through questionnaires. In the fourth year from baseline, the diagnosis of the three diseases will be collected.RESULTS: The unnecessary referral rate will be compared between NELCIN-B3 and standard protocol for managing early-detected lung nodules. The effectiveness of quantitative measurement of CT imaging biomarkers for early detection of lung cancer, COPD and CVD will be evaluated.CONCLUSION: We expect that the quantitative assessment of the CT imaging biomarkers will reduce the number of unnecessary referrals for early detected lung nodules, and will improve the early detection of COPD and CVD in a Chinese urban population.TRIAL REGISTRATION: ClinicalTrials.gov, NCT03988322. Registered on 14 June 2019.
AB - RATIONALE AND OBJECTIVES: To describe the rational and design of a population-based comparative study. The objective of the study is to assess the screening performance of volume-based management of CT-detected lung nodule in comparison to diameter-based management, and to improve the effectiveness of CT screening for chronic obstructive pulmonary disease (COPD) and cardiovascular disease (CVD), in addition to lung cancer, based on quantitative measurement of CT imaging biomarkers in a Chinese screening setting.MATERIALS AND METHODS: A population-based comparative study is being performed, including 10,000 asymptomatic participants between 40 and 74 years old from Shanghai urban population. Participants in the intervention group undergo a low-dose chest and cardiac CT scan at baseline and 1 year later, and are managed according to NELCIN-B3 protocol. Participants in the control group undergo a low-dose chest CT scan according to the routine CT protocol and are managed according to the clinical practice. Epidemiological data are collected through questionnaires. In the fourth year from baseline, the diagnosis of the three diseases will be collected.RESULTS: The unnecessary referral rate will be compared between NELCIN-B3 and standard protocol for managing early-detected lung nodules. The effectiveness of quantitative measurement of CT imaging biomarkers for early detection of lung cancer, COPD and CVD will be evaluated.CONCLUSION: We expect that the quantitative assessment of the CT imaging biomarkers will reduce the number of unnecessary referrals for early detected lung nodules, and will improve the early detection of COPD and CVD in a Chinese urban population.TRIAL REGISTRATION: ClinicalTrials.gov, NCT03988322. Registered on 14 June 2019.
KW - Adult
KW - Aged
KW - Cardiovascular Diseases/diagnostic imaging
KW - China/epidemiology
KW - Early Detection of Cancer
KW - Humans
KW - Lung Neoplasms/diagnostic imaging
KW - Middle Aged
KW - Pulmonary Disease, Chronic Obstructive/diagnostic imaging
KW - Tomography, X-Ray Computed
U2 - 10.1016/j.acra.2020.01.020
DO - 10.1016/j.acra.2020.01.020
M3 - Article
C2 - 32151538
SN - 1076-6332
VL - 28
SP - 36
EP - 45
JO - Academic Radiology
JF - Academic Radiology
IS - 1
ER -