Computed tomography detects tissue formation in a stented engineered heart valve

L.M. de Heer; R.P.J. Budde; E.P.A. Vonken; F.P.T. Baaijens; P.F. Gründeman; L.A. van Herwerden; S.P. Hoerstrup; J. Kluin

doi:10.1016/j.athoracsur.2010.12.063

Computed tomography detects tissue formation in a stented engineered heart valve

L.M. de Heer, R.P.J. Budde, E.P.A. Vonken, F.P.T. Baaijens, P.F. Gründeman, L.A. van Herwerden, S.P. Hoerstrup, J. Kluin

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Tissue-engineered heart valves (TEHV) are being explored as an alternative to conventional heart valve prostheses. Using the classic tissue engineering paradigm, a stented tri-leaflet valve is fabricated. Subsequently, the construct is implanted into the pulmonary position in a sheep. Follow-up by means of computed tomography, magnetic resonance imaging, and echocardiography was used to assess tissue formation. After 4 weeks, the scaffold of the TEHV has degraded and new tissue is formed. However, small areas without tissue formation were present at macroscopic inspection. This phenomenon was only visible on computed tomographic images. Therefore, computed tomography appears a promising technique for in vivo follow-up of tissue formation in tissue-engineered heart valves.

Original language	English
Pages (from-to)	344-345
Number of pages	2
Journal	Annals of Thoracic Surgery
Volume	92
Issue number	1
DOIs	https://doi.org/10.1016/j.athoracsur.2010.12.063
Publication status	Published - Jul 2011

Keywords

Animals
Diagnostic Imaging
Disease Models, Animal
Echocardiography, Doppler
Follow-Up Studies
Graft Survival
Heart Valve Prosthesis
Heart Valve Prosthesis Implantation
Magnetic Resonance Imaging
Pulmonary Valve
Risk Assessment
Sheep
Stents
Time Factors
Tissue Engineering
Tomography, X-Ray Computed

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10.1016/j.athoracsur.2010.12.063

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title = "Computed tomography detects tissue formation in a stented engineered heart valve",

abstract = "Tissue-engineered heart valves (TEHV) are being explored as an alternative to conventional heart valve prostheses. Using the classic tissue engineering paradigm, a stented tri-leaflet valve is fabricated. Subsequently, the construct is implanted into the pulmonary position in a sheep. Follow-up by means of computed tomography, magnetic resonance imaging, and echocardiography was used to assess tissue formation. After 4 weeks, the scaffold of the TEHV has degraded and new tissue is formed. However, small areas without tissue formation were present at macroscopic inspection. This phenomenon was only visible on computed tomographic images. Therefore, computed tomography appears a promising technique for in vivo follow-up of tissue formation in tissue-engineered heart valves.",

keywords = "Animals, Diagnostic Imaging, Disease Models, Animal, Echocardiography, Doppler, Follow-Up Studies, Graft Survival, Heart Valve Prosthesis, Heart Valve Prosthesis Implantation, Magnetic Resonance Imaging, Pulmonary Valve, Risk Assessment, Sheep, Stents, Time Factors, Tissue Engineering, Tomography, X-Ray Computed",

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year = "2011",

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doi = "10.1016/j.athoracsur.2010.12.063",

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AU - de Heer, L.M.

AU - Budde, R.P.J.

AU - Vonken, E.P.A.

AU - Baaijens, F.P.T.

AU - Gründeman, P.F.

AU - van Herwerden, L.A.

AU - Hoerstrup, S.P.

AU - Kluin, J.

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N2 - Tissue-engineered heart valves (TEHV) are being explored as an alternative to conventional heart valve prostheses. Using the classic tissue engineering paradigm, a stented tri-leaflet valve is fabricated. Subsequently, the construct is implanted into the pulmonary position in a sheep. Follow-up by means of computed tomography, magnetic resonance imaging, and echocardiography was used to assess tissue formation. After 4 weeks, the scaffold of the TEHV has degraded and new tissue is formed. However, small areas without tissue formation were present at macroscopic inspection. This phenomenon was only visible on computed tomographic images. Therefore, computed tomography appears a promising technique for in vivo follow-up of tissue formation in tissue-engineered heart valves.

AB - Tissue-engineered heart valves (TEHV) are being explored as an alternative to conventional heart valve prostheses. Using the classic tissue engineering paradigm, a stented tri-leaflet valve is fabricated. Subsequently, the construct is implanted into the pulmonary position in a sheep. Follow-up by means of computed tomography, magnetic resonance imaging, and echocardiography was used to assess tissue formation. After 4 weeks, the scaffold of the TEHV has degraded and new tissue is formed. However, small areas without tissue formation were present at macroscopic inspection. This phenomenon was only visible on computed tomographic images. Therefore, computed tomography appears a promising technique for in vivo follow-up of tissue formation in tissue-engineered heart valves.

KW - Animals

KW - Diagnostic Imaging

KW - Disease Models, Animal

KW - Echocardiography, Doppler

KW - Follow-Up Studies

KW - Graft Survival

KW - Heart Valve Prosthesis

KW - Heart Valve Prosthesis Implantation

KW - Magnetic Resonance Imaging

KW - Pulmonary Valve

KW - Risk Assessment

KW - Sheep

KW - Stents

KW - Time Factors

KW - Tissue Engineering

KW - Tomography, X-Ray Computed

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DO - 10.1016/j.athoracsur.2010.12.063

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SP - 344

EP - 345

JO - Annals of Thoracic Surgery

JF - Annals of Thoracic Surgery

IS - 1

ER -

Computed tomography detects tissue formation in a stented engineered heart valve

Abstract

Keywords

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