COMPULS: design of a multicenter phenotypic, cognitive, genetic, and magnetic resonance imaging study in children with compulsive syndromes

Jilly Naaijen; Saskia de Ruiter; Marcel P. Zwiers; Jeffrey C. Glennon; Sarah Durston; David J. Lythgoe; Steven C. R. Williams; Tobias Banaschewski; Daniel Brandeis; Barbara Franke; Jan K. Buitelaar

doi:10.1186/s12888-016-1072-6

COMPULS: design of a multicenter phenotypic, cognitive, genetic, and magnetic resonance imaging study in children with compulsive syndromes

Jilly Naaijen, Saskia de Ruiter, Marcel P. Zwiers, Jeffrey C. Glennon, Sarah Durston, David J. Lythgoe, Steven C. R. Williams, Tobias Banaschewski, Daniel Brandeis, Barbara Franke, Jan K. Buitelaar

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Abstract

Background: Compulsivity, the closely linked trait impulsivity and addictive behaviour are associated with several
neurodevelopmental disorders, including attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder
(ASD), and obsessive compulsive disorder (OCD). All three disorders show impaired fronto-striatal functioning, which
may be related to altered glutamatergic signalling. Genetic factors are also thought to play an important role in the
aetiology of compulsivity-related disorders.
Methods: The COMPULS study is a multi-center study designed to investigate the relationship between the traits
compulsivity, impulsivity, and, to a lesser extent, addictive behaviour within and across the neurodevelopmental disorders
ADHD, ASD, and OCD. This will be done at the phenotypic, cognitive, neural, and genetic level. In total,
240 participants will take part in COMPULS across four different sites in Europe. Data collection will include
diagnostic interviews, behavioural questionnaires, cognitive measures, structural, functional and spectral
neuroimaging, and genome-wide genetic information.
Discussion: The COMPULS study will offer the unique opportunity to investigate several key aspects of
compulsivity across a large cohort of ADHD, ASD and OCD patients.

Original language	English
Pages (from-to)	16:361
Journal	BMC psychiatry [E]
Volume	16
DOIs	https://doi.org/10.1186/s12888-016-1072-6
Publication status	Published - 26 Oct 2016

Keywords

Compulsivity
Fronto-striatal circuit
Glutamate
ADHD
ASD
OCD

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Naaijen, J., de Ruiter, S., Zwiers, M. P., Glennon, J. C., Durston, S., Lythgoe, D. J., Williams, S. C. R., Banaschewski, T., Brandeis, D., Franke, B., & Buitelaar, J. K. (2016). COMPULS: design of a multicenter phenotypic, cognitive, genetic, and magnetic resonance imaging study in children with compulsive syndromes. BMC psychiatry [E], 16, 16:361. https://doi.org/10.1186/s12888-016-1072-6

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title = "COMPULS: design of a multicenter phenotypic, cognitive, genetic, and magnetic resonance imaging study in children with compulsive syndromes",

abstract = "Background: Compulsivity, the closely linked trait impulsivity and addictive behaviour are associated with severalneurodevelopmental disorders, including attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder(ASD), and obsessive compulsive disorder (OCD). All three disorders show impaired fronto-striatal functioning, whichmay be related to altered glutamatergic signalling. Genetic factors are also thought to play an important role in theaetiology of compulsivity-related disorders.Methods: The COMPULS study is a multi-center study designed to investigate the relationship between the traitscompulsivity, impulsivity, and, to a lesser extent, addictive behaviour within and across the neurodevelopmental disordersADHD, ASD, and OCD. This will be done at the phenotypic, cognitive, neural, and genetic level. In total,240 participants will take part in COMPULS across four different sites in Europe. Data collection will includediagnostic interviews, behavioural questionnaires, cognitive measures, structural, functional and spectralneuroimaging, and genome-wide genetic information.Discussion: The COMPULS study will offer the unique opportunity to investigate several key aspects ofcompulsivity across a large cohort of ADHD, ASD and OCD patients.",

keywords = "Compulsivity, Fronto-striatal circuit, Glutamate, ADHD, ASD, OCD",

author = "Jilly Naaijen and {de Ruiter}, Saskia and Zwiers, {Marcel P.} and Glennon, {Jeffrey C.} and Sarah Durston and Lythgoe, {David J.} and Williams, {Steven C. R.} and Tobias Banaschewski and Daniel Brandeis and Barbara Franke and Buitelaar, {Jan K.}",

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doi = "10.1186/s12888-016-1072-6",

language = "English",

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pages = "16:361",

journal = "BMC psychiatry [E]",

issn = "1471-244X",

publisher = "BioMed Central",

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Naaijen, J, de Ruiter, S, Zwiers, MP, Glennon, JC, Durston, S, Lythgoe, DJ, Williams, SCR, Banaschewski, T, Brandeis, D, Franke, B & Buitelaar, JK 2016, 'COMPULS: design of a multicenter phenotypic, cognitive, genetic, and magnetic resonance imaging study in children with compulsive syndromes', BMC psychiatry [E], vol. 16, pp. 16:361. https://doi.org/10.1186/s12888-016-1072-6

TY - JOUR

T1 - COMPULS: design of a multicenter phenotypic, cognitive, genetic, and magnetic resonance imaging study in children with compulsive syndromes

AU - Naaijen, Jilly

AU - de Ruiter, Saskia

AU - Zwiers, Marcel P.

AU - Glennon, Jeffrey C.

AU - Durston, Sarah

AU - Lythgoe, David J.

AU - Williams, Steven C. R.

AU - Banaschewski, Tobias

AU - Brandeis, Daniel

AU - Franke, Barbara

AU - Buitelaar, Jan K.

PY - 2016/10/26

Y1 - 2016/10/26

N2 - Background: Compulsivity, the closely linked trait impulsivity and addictive behaviour are associated with severalneurodevelopmental disorders, including attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder(ASD), and obsessive compulsive disorder (OCD). All three disorders show impaired fronto-striatal functioning, whichmay be related to altered glutamatergic signalling. Genetic factors are also thought to play an important role in theaetiology of compulsivity-related disorders.Methods: The COMPULS study is a multi-center study designed to investigate the relationship between the traitscompulsivity, impulsivity, and, to a lesser extent, addictive behaviour within and across the neurodevelopmental disordersADHD, ASD, and OCD. This will be done at the phenotypic, cognitive, neural, and genetic level. In total,240 participants will take part in COMPULS across four different sites in Europe. Data collection will includediagnostic interviews, behavioural questionnaires, cognitive measures, structural, functional and spectralneuroimaging, and genome-wide genetic information.Discussion: The COMPULS study will offer the unique opportunity to investigate several key aspects ofcompulsivity across a large cohort of ADHD, ASD and OCD patients.

AB - Background: Compulsivity, the closely linked trait impulsivity and addictive behaviour are associated with severalneurodevelopmental disorders, including attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder(ASD), and obsessive compulsive disorder (OCD). All three disorders show impaired fronto-striatal functioning, whichmay be related to altered glutamatergic signalling. Genetic factors are also thought to play an important role in theaetiology of compulsivity-related disorders.Methods: The COMPULS study is a multi-center study designed to investigate the relationship between the traitscompulsivity, impulsivity, and, to a lesser extent, addictive behaviour within and across the neurodevelopmental disordersADHD, ASD, and OCD. This will be done at the phenotypic, cognitive, neural, and genetic level. In total,240 participants will take part in COMPULS across four different sites in Europe. Data collection will includediagnostic interviews, behavioural questionnaires, cognitive measures, structural, functional and spectralneuroimaging, and genome-wide genetic information.Discussion: The COMPULS study will offer the unique opportunity to investigate several key aspects ofcompulsivity across a large cohort of ADHD, ASD and OCD patients.

KW - Compulsivity

KW - Fronto-striatal circuit

KW - Glutamate

KW - ADHD

KW - ASD

KW - OCD

U2 - 10.1186/s12888-016-1072-6

DO - 10.1186/s12888-016-1072-6

M3 - Article

C2 - 27782808

SN - 1471-244X

VL - 16

SP - 16:361

JO - BMC psychiatry [E]

JF - BMC psychiatry [E]

ER -

COMPULS: design of a multicenter phenotypic, cognitive, genetic, and magnetic resonance imaging study in children with compulsive syndromes

Abstract

Keywords

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