Complete Genome Sequence of the Itraconazole Decreased Susceptible Madurella fahalii Type-Strain CBS 129176

Mickey Konings; Bert Gerrits van den Ende; Mirthe W.J. Raats; Ahmed Hassan Fahal; Wendy W.J. van de Sande; Ferry Hagen

doi:10.1007/s11046-023-00807-0

Complete Genome Sequence of the Itraconazole Decreased Susceptible Madurella fahalii Type-Strain CBS 129176

Mickey Konings, Bert Gerrits van den Ende, Mirthe W.J. Raats, Ahmed Hassan Fahal, Wendy W.J. van de Sande^*, Ferry Hagen

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Madurella fahalii is a causative agent of the implantation mycosis mycetoma with decreased susceptibility to itraconazole, the preferred therapeutic drug to combat mycetoma. Here, we report the M. fahalii type-strain CBS 129176 genome assembly and annotation to identify a glutamic acid insert near the azole-binding pocket in the Cyp51A protein.

Original language	English
Article number	6
Journal	Mycopathologia
Volume	189
Issue number	1
DOIs	https://doi.org/10.1007/s11046-023-00807-0
Publication status	Published - Feb 2024

Keywords

De novo genome assembly
Decreased itraconazole susceptibility
Madurella fahalii
Madurella mycetomatis
Nanopore sequencing

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title = "Complete Genome Sequence of the Itraconazole Decreased Susceptible Madurella fahalii Type-Strain CBS 129176",

abstract = "Madurella fahalii is a causative agent of the implantation mycosis mycetoma with decreased susceptibility to itraconazole, the preferred therapeutic drug to combat mycetoma. Here, we report the M. fahalii type-strain CBS 129176 genome assembly and annotation to identify a glutamic acid insert near the azole-binding pocket in the Cyp51A protein.",

keywords = "De novo genome assembly, Decreased itraconazole susceptibility, Madurella fahalii, Madurella mycetomatis, Nanopore sequencing",

author = "Mickey Konings and {Gerrits van den Ende}, Bert and Raats, {Mirthe W.J.} and Fahal, {Ahmed Hassan} and {van de Sande}, {Wendy W.J.} and Ferry Hagen",

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AU - Gerrits van den Ende, Bert

AU - Raats, Mirthe W.J.

AU - Fahal, Ahmed Hassan

AU - van de Sande, Wendy W.J.

AU - Hagen, Ferry

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AB - Madurella fahalii is a causative agent of the implantation mycosis mycetoma with decreased susceptibility to itraconazole, the preferred therapeutic drug to combat mycetoma. Here, we report the M. fahalii type-strain CBS 129176 genome assembly and annotation to identify a glutamic acid insert near the azole-binding pocket in the Cyp51A protein.

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KW - Decreased itraconazole susceptibility

KW - Madurella fahalii

KW - Madurella mycetomatis

KW - Nanopore sequencing

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Complete Genome Sequence of the Itraconazole Decreased Susceptible Madurella fahalii Type-Strain CBS 129176

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