Complement receptor 1 single nucleotide polymorphisms in Czech and Dutch patients with sarcoidosis

F. Mrazek; M. Kvezereli; E. Garr; Z. Kubistova; E. Kriegova; R. Fillerova; A. Arakelyan; H. J.T. Ruven; J. Drabek; J. M.M. Van Den Bosch; V. Kolek; K. I. Welsh; J. C. Grutters; R. M. Du Bois; M. Petrek

doi:10.1111/j.1399-0039.2007.00957.x

Complement receptor 1 single nucleotide polymorphisms in Czech and Dutch patients with sarcoidosis

F. Mrazek, M. Kvezereli, E. Garr, Z. Kubistova, E. Kriegova, R. Fillerova, A. Arakelyan, H. J.T. Ruven, J. Drabek, J. M.M. Van Den Bosch, V. Kolek, K. I. Welsh, J. C. Grutters, R. M. Du Bois, M. Petrek^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

7 Citations (Scopus)

Abstract

A single nucleotide polymorphism (SNP) C5507G of the complement receptor 1 (CR1) gene has been associated with genetic susceptibility to sarcoidosis in an Italian population. In order to provide further data on the possible involvement of CR1 gene polymorphisms in sarcoidosis, CR1 SNPs C5507G and A3650G were investigated in Czech (n = 210) and Dutch (n = 116) patients with sarcoidosis with ethnically matched groups of healthy control subjects (Czech, n = 203; Dutch, n = 112). CR1 C5507G and A3650G SNPs were not associated with susceptibility to sarcoidosis or its clinical course. Further, CR1 messenger RNA expression in bronchoalveolar lavage cells investigated by quantitative reverse transcriptase-polymerase chain reaction did not differ between sarcoidosis patients and control subjects and was not associated with the presence of the CR1 5507*G allele.

Original language	English
Pages (from-to)	77-80
Number of pages	4
Journal	Tissue Antigens
Volume	71
Issue number	1
DOIs	https://doi.org/10.1111/j.1399-0039.2007.00957.x
Publication status	Published - Jan 2008
Externally published	Yes

Keywords

CR1
Genetics of complex diseases
Replication of a case-control study
Sarcoidosis

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10.1111/j.1399-0039.2007.00957.x

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Mrazek, F., Kvezereli, M., Garr, E., Kubistova, Z., Kriegova, E., Fillerova, R., Arakelyan, A., Ruven, H. J. T., Drabek, J., Van Den Bosch, J. M. M., Kolek, V., Welsh, K. I., Grutters, J. C., Du Bois, R. M., & Petrek, M. (2008). Complement receptor 1 single nucleotide polymorphisms in Czech and Dutch patients with sarcoidosis. Tissue Antigens, 71(1), 77-80. https://doi.org/10.1111/j.1399-0039.2007.00957.x

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title = "Complement receptor 1 single nucleotide polymorphisms in Czech and Dutch patients with sarcoidosis",

abstract = "A single nucleotide polymorphism (SNP) C5507G of the complement receptor 1 (CR1) gene has been associated with genetic susceptibility to sarcoidosis in an Italian population. In order to provide further data on the possible involvement of CR1 gene polymorphisms in sarcoidosis, CR1 SNPs C5507G and A3650G were investigated in Czech (n = 210) and Dutch (n = 116) patients with sarcoidosis with ethnically matched groups of healthy control subjects (Czech, n = 203; Dutch, n = 112). CR1 C5507G and A3650G SNPs were not associated with susceptibility to sarcoidosis or its clinical course. Further, CR1 messenger RNA expression in bronchoalveolar lavage cells investigated by quantitative reverse transcriptase-polymerase chain reaction did not differ between sarcoidosis patients and control subjects and was not associated with the presence of the CR1 5507*G allele.",

keywords = "CR1, Genetics of complex diseases, Replication of a case-control study, Sarcoidosis",

author = "F. Mrazek and M. Kvezereli and E. Garr and Z. Kubistova and E. Kriegova and R. Fillerova and A. Arakelyan and Ruven, {H. J.T.} and J. Drabek and {Van Den Bosch}, {J. M.M.} and V. Kolek and Welsh, {K. I.} and Grutters, {J. C.} and {Du Bois}, {R. M.} and M. Petrek",

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doi = "10.1111/j.1399-0039.2007.00957.x",

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Mrazek, F, Kvezereli, M, Garr, E, Kubistova, Z, Kriegova, E, Fillerova, R, Arakelyan, A, Ruven, HJT, Drabek, J, Van Den Bosch, JMM, Kolek, V, Welsh, KI, Grutters, JC, Du Bois, RM & Petrek, M 2008, 'Complement receptor 1 single nucleotide polymorphisms in Czech and Dutch patients with sarcoidosis', Tissue Antigens, vol. 71, no. 1, pp. 77-80. https://doi.org/10.1111/j.1399-0039.2007.00957.x

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AU - Mrazek, F.

AU - Kvezereli, M.

AU - Garr, E.

AU - Kubistova, Z.

AU - Kriegova, E.

AU - Fillerova, R.

AU - Arakelyan, A.

AU - Ruven, H. J.T.

AU - Drabek, J.

AU - Van Den Bosch, J. M.M.

AU - Kolek, V.

AU - Welsh, K. I.

AU - Grutters, J. C.

AU - Du Bois, R. M.

AU - Petrek, M.

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N2 - A single nucleotide polymorphism (SNP) C5507G of the complement receptor 1 (CR1) gene has been associated with genetic susceptibility to sarcoidosis in an Italian population. In order to provide further data on the possible involvement of CR1 gene polymorphisms in sarcoidosis, CR1 SNPs C5507G and A3650G were investigated in Czech (n = 210) and Dutch (n = 116) patients with sarcoidosis with ethnically matched groups of healthy control subjects (Czech, n = 203; Dutch, n = 112). CR1 C5507G and A3650G SNPs were not associated with susceptibility to sarcoidosis or its clinical course. Further, CR1 messenger RNA expression in bronchoalveolar lavage cells investigated by quantitative reverse transcriptase-polymerase chain reaction did not differ between sarcoidosis patients and control subjects and was not associated with the presence of the CR1 5507*G allele.

AB - A single nucleotide polymorphism (SNP) C5507G of the complement receptor 1 (CR1) gene has been associated with genetic susceptibility to sarcoidosis in an Italian population. In order to provide further data on the possible involvement of CR1 gene polymorphisms in sarcoidosis, CR1 SNPs C5507G and A3650G were investigated in Czech (n = 210) and Dutch (n = 116) patients with sarcoidosis with ethnically matched groups of healthy control subjects (Czech, n = 203; Dutch, n = 112). CR1 C5507G and A3650G SNPs were not associated with susceptibility to sarcoidosis or its clinical course. Further, CR1 messenger RNA expression in bronchoalveolar lavage cells investigated by quantitative reverse transcriptase-polymerase chain reaction did not differ between sarcoidosis patients and control subjects and was not associated with the presence of the CR1 5507*G allele.

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ER -

Complement receptor 1 single nucleotide polymorphisms in Czech and Dutch patients with sarcoidosis

Abstract

Keywords

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