Comparisons of oxygen gradient ektacytometry parameters between sickle cell patients with or without α-thalassaemia

Camille Boisson; Céline Renoux; Elie Nader; Alexandra Gauthier; Solène Poutrel; Minke Rab; Romain Fort; Yves Bertrand; Emeric Stauffer; Giovanna Cannas; Kamila Kebaili; Emilie Virot; Arnaud Hot; Vivien Sheehan; Eduard van Beers; Richard van Wijk; Philippe Joly; Philippe Connes

doi:10.1111/bjh.17777

Comparisons of oxygen gradient ektacytometry parameters between sickle cell patients with or without α-thalassaemia

Camille Boisson
, Céline Renoux
, Elie Nader
, Alexandra Gauthier
, Solène Poutrel
, Minke Rab
, Romain Fort
, Yves Bertrand
, Emeric Stauffer
, Giovanna Cannas
, Kamila Kebaili
, Emilie Virot
, Arnaud Hot
, Vivien Sheehan
, Eduard van Beers
, Richard van Wijk
, Philippe Joly
, Philippe Connes

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The present study tested the impact of α-thalassaemia on oxygen gradient ektacytometry in sickle cell anaemia (SCA). Three SCA groups were compared: (i) no α-thalassaemia (four α-genes, n = 62), (ii) silent α-thalassaemia (three α-genes, n = 35) and (iii) homozygous α-thalassaemia (two α-genes, n = 12). Red blood cell (RBC) deformability measured in normoxia was not different between the three groups. The lowest RBC deformability reached at low oxygen partial pressure (pO2 ) was greater and the pO2 at which RBC started to sickle was lower in the two α-genes group compared to the other groups. Our present study showed an effect of α-thalassaemia on oxygen gradient ektacytometry in SCA.

Original language	English
Pages (from-to)	629-633
Number of pages	5
Journal	British Journal of Haematology
Volume	195
Issue number	4
Early online date	15 Aug 2021
DOIs	https://doi.org/10.1111/bjh.17777
Publication status	Published - Nov 2021

Keywords

red blood cell deformability
sickle cell disease
sickling
α-thalassaemia

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10.1111/bjh.17777

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Boisson, C., Renoux, C., Nader, E., Gauthier, A., Poutrel, S., Rab, M., Fort, R., Bertrand, Y., Stauffer, E., Cannas, G., Kebaili, K., Virot, E., Hot, A., Sheehan, V., van Beers, E., van Wijk, R., Joly, P., & Connes, P. (2021). Comparisons of oxygen gradient ektacytometry parameters between sickle cell patients with or without α-thalassaemia. British Journal of Haematology, 195(4), 629-633. https://doi.org/10.1111/bjh.17777

@article{c528cafb37fc40c1958f20a29235541e,

title = "Comparisons of oxygen gradient ektacytometry parameters between sickle cell patients with or without α-thalassaemia",

abstract = "The present study tested the impact of α-thalassaemia on oxygen gradient ektacytometry in sickle cell anaemia (SCA). Three SCA groups were compared: (i) no α-thalassaemia (four α-genes, n = 62), (ii) silent α-thalassaemia (three α-genes, n = 35) and (iii) homozygous α-thalassaemia (two α-genes, n = 12). Red blood cell (RBC) deformability measured in normoxia was not different between the three groups. The lowest RBC deformability reached at low oxygen partial pressure (pO2 ) was greater and the pO2 at which RBC started to sickle was lower in the two α-genes group compared to the other groups. Our present study showed an effect of α-thalassaemia on oxygen gradient ektacytometry in SCA.",

keywords = "red blood cell deformability, sickle cell disease, sickling, α-thalassaemia",

author = "Camille Boisson and C{\'e}line Renoux and Elie Nader and Alexandra Gauthier and Sol{\`e}ne Poutrel and Minke Rab and Romain Fort and Yves Bertrand and Emeric Stauffer and Giovanna Cannas and Kamila Kebaili and Emilie Virot and Arnaud Hot and Vivien Sheehan and \{van Beers\}, Eduard and \{van Wijk\}, Richard and Philippe Joly and Philippe Connes",

note = "Funding Information: This research has been funded by Eurostars grant estar18105. Publisher Copyright: {\textcopyright} 2021 British Society for Haematology and John Wiley \& Sons Ltd",

year = "2021",

month = nov,

doi = "10.1111/bjh.17777",

language = "English",

volume = "195",

pages = "629--633",

journal = "British Journal of Haematology",

issn = "0007-1048",

publisher = "John Wiley \& Sons Inc.",

number = "4",

}

Boisson, C, Renoux, C, Nader, E, Gauthier, A, Poutrel, S, Rab, M, Fort, R, Bertrand, Y, Stauffer, E, Cannas, G, Kebaili, K, Virot, E, Hot, A, Sheehan, V, van Beers, E , van Wijk, R, Joly, P & Connes, P 2021, 'Comparisons of oxygen gradient ektacytometry parameters between sickle cell patients with or without α-thalassaemia', British Journal of Haematology, vol. 195, no. 4, pp. 629-633. https://doi.org/10.1111/bjh.17777

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T1 - Comparisons of oxygen gradient ektacytometry parameters between sickle cell patients with or without α-thalassaemia

AU - Boisson, Camille

AU - Renoux, Céline

AU - Nader, Elie

AU - Gauthier, Alexandra

AU - Poutrel, Solène

AU - Rab, Minke

AU - Fort, Romain

AU - Bertrand, Yves

AU - Stauffer, Emeric

AU - Cannas, Giovanna

AU - Kebaili, Kamila

AU - Virot, Emilie

AU - Hot, Arnaud

AU - Sheehan, Vivien

AU - van Beers, Eduard

AU - van Wijk, Richard

AU - Joly, Philippe

AU - Connes, Philippe

PY - 2021/11

Y1 - 2021/11

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AB - The present study tested the impact of α-thalassaemia on oxygen gradient ektacytometry in sickle cell anaemia (SCA). Three SCA groups were compared: (i) no α-thalassaemia (four α-genes, n = 62), (ii) silent α-thalassaemia (three α-genes, n = 35) and (iii) homozygous α-thalassaemia (two α-genes, n = 12). Red blood cell (RBC) deformability measured in normoxia was not different between the three groups. The lowest RBC deformability reached at low oxygen partial pressure (pO2 ) was greater and the pO2 at which RBC started to sickle was lower in the two α-genes group compared to the other groups. Our present study showed an effect of α-thalassaemia on oxygen gradient ektacytometry in SCA.

KW - red blood cell deformability

KW - sickle cell disease

KW - sickling

KW - α-thalassaemia

UR - https://www.scopus.com/pages/publications/85112416363

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DO - 10.1111/bjh.17777

M3 - Article

C2 - 34396507

SN - 0007-1048

VL - 195

SP - 629

EP - 633

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 4

ER -

Comparisons of oxygen gradient ektacytometry parameters between sickle cell patients with or without α-thalassaemia

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Keywords

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