Comparisons of oxygen gradient ektacytometry parameters between sickle cell patients with or without α-thalassaemia

Camille Boisson; Céline Renoux; Elie Nader; Alexandra Gauthier; Solène Poutrel; Minke Rab; Romain Fort; Yves Bertrand; Emeric Stauffer; Giovanna Cannas; Kamila Kebaili; Emilie Virot; Arnaud Hot; Vivien Sheehan; Eduard van Beers; Richard van Wijk; Philippe Joly; Philippe Connes

doi:10.1111/bjh.17777

Comparisons of oxygen gradient ektacytometry parameters between sickle cell patients with or without α-thalassaemia

Camille Boisson, Céline Renoux, Elie Nader, Alexandra Gauthier, Solène Poutrel, Minke Rab, Romain Fort, Yves Bertrand, Emeric Stauffer, Giovanna Cannas, Kamila Kebaili, Emilie Virot, Arnaud Hot, Vivien Sheehan, Eduard van Beers, Richard van Wijk, Philippe Joly, Philippe Connes

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The present study tested the impact of α-thalassaemia on oxygen gradient ektacytometry in sickle cell anaemia (SCA). Three SCA groups were compared: (i) no α-thalassaemia (four α-genes, n = 62), (ii) silent α-thalassaemia (three α-genes, n = 35) and (iii) homozygous α-thalassaemia (two α-genes, n = 12). Red blood cell (RBC) deformability measured in normoxia was not different between the three groups. The lowest RBC deformability reached at low oxygen partial pressure (pO2 ) was greater and the pO2 at which RBC started to sickle was lower in the two α-genes group compared to the other groups. Our present study showed an effect of α-thalassaemia on oxygen gradient ektacytometry in SCA.

Original language	English
Pages (from-to)	629-633
Number of pages	5
Journal	British Journal of Haematology
Volume	195
Issue number	4
Early online date	15 Aug 2021
DOIs	https://doi.org/10.1111/bjh.17777
Publication status	Published - Nov 2021

Keywords

red blood cell deformability
sickle cell disease
sickling
α-thalassaemia

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10.1111/bjh.17777

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Boisson, C., Renoux, C., Nader, E., Gauthier, A., Poutrel, S., Rab, M., Fort, R., Bertrand, Y., Stauffer, E., Cannas, G., Kebaili, K., Virot, E., Hot, A., Sheehan, V., van Beers, E., van Wijk, R., Joly, P., & Connes, P. (2021). Comparisons of oxygen gradient ektacytometry parameters between sickle cell patients with or without α-thalassaemia. British Journal of Haematology, 195(4), 629-633. https://doi.org/10.1111/bjh.17777

@article{c528cafb37fc40c1958f20a29235541e,

title = "Comparisons of oxygen gradient ektacytometry parameters between sickle cell patients with or without α-thalassaemia",

abstract = "The present study tested the impact of α-thalassaemia on oxygen gradient ektacytometry in sickle cell anaemia (SCA). Three SCA groups were compared: (i) no α-thalassaemia (four α-genes, n = 62), (ii) silent α-thalassaemia (three α-genes, n = 35) and (iii) homozygous α-thalassaemia (two α-genes, n = 12). Red blood cell (RBC) deformability measured in normoxia was not different between the three groups. The lowest RBC deformability reached at low oxygen partial pressure (pO2 ) was greater and the pO2 at which RBC started to sickle was lower in the two α-genes group compared to the other groups. Our present study showed an effect of α-thalassaemia on oxygen gradient ektacytometry in SCA.",

keywords = "red blood cell deformability, sickle cell disease, sickling, α-thalassaemia",

author = "Camille Boisson and C{\'e}line Renoux and Elie Nader and Alexandra Gauthier and Sol{\`e}ne Poutrel and Minke Rab and Romain Fort and Yves Bertrand and Emeric Stauffer and Giovanna Cannas and Kamila Kebaili and Emilie Virot and Arnaud Hot and Vivien Sheehan and {van Beers}, Eduard and {van Wijk}, Richard and Philippe Joly and Philippe Connes",

note = "Funding Information: This research has been funded by Eurostars grant estar18105. Publisher Copyright: {\textcopyright} 2021 British Society for Haematology and John Wiley & Sons Ltd",

year = "2021",

month = nov,

doi = "10.1111/bjh.17777",

language = "English",

volume = "195",

pages = "629--633",

journal = "British Journal of Haematology",

issn = "0007-1048",

publisher = "Wiley-Blackwell",

number = "4",

}

Boisson, C, Renoux, C, Nader, E, Gauthier, A, Poutrel, S, Rab, M, Fort, R, Bertrand, Y, Stauffer, E, Cannas, G, Kebaili, K, Virot, E, Hot, A, Sheehan, V, van Beers, E , van Wijk, R, Joly, P & Connes, P 2021, 'Comparisons of oxygen gradient ektacytometry parameters between sickle cell patients with or without α-thalassaemia', British Journal of Haematology, vol. 195, no. 4, pp. 629-633. https://doi.org/10.1111/bjh.17777

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T1 - Comparisons of oxygen gradient ektacytometry parameters between sickle cell patients with or without α-thalassaemia

AU - Boisson, Camille

AU - Renoux, Céline

AU - Nader, Elie

AU - Gauthier, Alexandra

AU - Poutrel, Solène

AU - Rab, Minke

AU - Fort, Romain

AU - Bertrand, Yves

AU - Stauffer, Emeric

AU - Cannas, Giovanna

AU - Kebaili, Kamila

AU - Virot, Emilie

AU - Hot, Arnaud

AU - Sheehan, Vivien

AU - van Beers, Eduard

AU - van Wijk, Richard

AU - Joly, Philippe

AU - Connes, Philippe

PY - 2021/11

Y1 - 2021/11

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AB - The present study tested the impact of α-thalassaemia on oxygen gradient ektacytometry in sickle cell anaemia (SCA). Three SCA groups were compared: (i) no α-thalassaemia (four α-genes, n = 62), (ii) silent α-thalassaemia (three α-genes, n = 35) and (iii) homozygous α-thalassaemia (two α-genes, n = 12). Red blood cell (RBC) deformability measured in normoxia was not different between the three groups. The lowest RBC deformability reached at low oxygen partial pressure (pO2 ) was greater and the pO2 at which RBC started to sickle was lower in the two α-genes group compared to the other groups. Our present study showed an effect of α-thalassaemia on oxygen gradient ektacytometry in SCA.

KW - red blood cell deformability

KW - sickle cell disease

KW - sickling

KW - α-thalassaemia

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DO - 10.1111/bjh.17777

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SP - 629

EP - 633

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 4

ER -

Comparisons of oxygen gradient ektacytometry parameters between sickle cell patients with or without α-thalassaemia

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Keywords

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