Comparison of two commercially available gamma interferon blood tests for immunodiagnosis of tuberculosis

Jose Domínguez; Juan Ruiz-Manzano; Malú De Souza-Galvão; Irene Latorre; Celia Milà; Silvia Blanco; M. Ángeles Jiménez; Cristina Prat; Alicia Lacoma; Neus Altet; Vicente Ausina

doi:10.1128/CVI.00364-07

Comparison of two commercially available gamma interferon blood tests for immunodiagnosis of tuberculosis

Jose Domínguez^*
, Juan Ruiz-Manzano
, Malú De Souza-Galvão
, Irene Latorre
, Celia Milà
, Silvia Blanco
, M. Ángeles Jiménez
, Cristina Prat
, Alicia Lacoma
, Neus Altet
, Vicente Ausina

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

119 Citations (Scopus)

Abstract

We evaluated the T-SPOT.TB and Quantiferon-TB Gold In tube (QFN-G-IT) tests for diagnosing Mycobacterium tuberculosis infection. T-SPOT.TB was more sensitive than QFN-G-IT in diagnosing both active and latent infection. Both gamma interferon tests were unaffected by prior Mycobacterium bovis BCG vaccination. Among children who were not BCG vaccinated but had a positive tuberculin skin test, QFN-G-IT was negative in 53.3% of cases, and T-SPOT.TB was negative in 50% of cases.

Original language	English
Pages (from-to)	168-171
Number of pages	4
Journal	Clinical and Vaccine Immunology
Volume	15
Issue number	1
DOIs	https://doi.org/10.1128/CVI.00364-07
Publication status	Published - Jan 2008
Externally published	Yes

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title = "Comparison of two commercially available gamma interferon blood tests for immunodiagnosis of tuberculosis",

abstract = "We evaluated the T-SPOT.TB and Quantiferon-TB Gold In tube (QFN-G-IT) tests for diagnosing Mycobacterium tuberculosis infection. T-SPOT.TB was more sensitive than QFN-G-IT in diagnosing both active and latent infection. Both gamma interferon tests were unaffected by prior Mycobacterium bovis BCG vaccination. Among children who were not BCG vaccinated but had a positive tuberculin skin test, QFN-G-IT was negative in 53.3\% of cases, and T-SPOT.TB was negative in 50\% of cases.",

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AU - Domínguez, Jose

AU - Ruiz-Manzano, Juan

AU - De Souza-Galvão, Malú

AU - Latorre, Irene

AU - Milà, Celia

AU - Blanco, Silvia

AU - Jiménez, M. Ángeles

AU - Prat, Cristina

AU - Lacoma, Alicia

AU - Altet, Neus

AU - Ausina, Vicente

PY - 2008/1

Y1 - 2008/1

N2 - We evaluated the T-SPOT.TB and Quantiferon-TB Gold In tube (QFN-G-IT) tests for diagnosing Mycobacterium tuberculosis infection. T-SPOT.TB was more sensitive than QFN-G-IT in diagnosing both active and latent infection. Both gamma interferon tests were unaffected by prior Mycobacterium bovis BCG vaccination. Among children who were not BCG vaccinated but had a positive tuberculin skin test, QFN-G-IT was negative in 53.3% of cases, and T-SPOT.TB was negative in 50% of cases.

AB - We evaluated the T-SPOT.TB and Quantiferon-TB Gold In tube (QFN-G-IT) tests for diagnosing Mycobacterium tuberculosis infection. T-SPOT.TB was more sensitive than QFN-G-IT in diagnosing both active and latent infection. Both gamma interferon tests were unaffected by prior Mycobacterium bovis BCG vaccination. Among children who were not BCG vaccinated but had a positive tuberculin skin test, QFN-G-IT was negative in 53.3% of cases, and T-SPOT.TB was negative in 50% of cases.

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AN - SCOPUS:43149119506

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SP - 168

EP - 171

JO - Clinical and Vaccine Immunology

JF - Clinical and Vaccine Immunology

IS - 1

ER -

Comparison of two commercially available gamma interferon blood tests for immunodiagnosis of tuberculosis

Abstract

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