Comparison of simplified parametric methods for visual interpretation of 11C-Pittsburgh compound-B PET images

Marissa D Zwan; Rik Ossenkoppele; Nelleke Tolboom; Alexandra J M Beunders; Reina W Kloet; Sofie M Adriaanse; Ronald Boellaard; Albert D Windhorst; Pieter Raijmakers; Human Adams; Adriaan A Lammertsma; Philip Scheltens; Wiesje M van der Flier; Bart N M van Berckel

doi:10.2967/jnumed.114.139121

Comparison of simplified parametric methods for visual interpretation of 11C-Pittsburgh compound-B PET images

Marissa D Zwan^*, Rik Ossenkoppele, Nelleke Tolboom, Alexandra J M Beunders, Reina W Kloet, Sofie M Adriaanse, Ronald Boellaard, Albert D Windhorst, Pieter Raijmakers, Human Adams, Adriaan A Lammertsma, Philip Scheltens, Wiesje M van der Flier, Bart N M van Berckel

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

UNLABELLED: This study compared several parametric imaging methods to determine the optimal approach for visual assessment of parametric Pittsburgh compound-B ((11)C-PIB) PET images to detect cortical amyloid deposition in different memory clinic patient groups.

METHODS: Dynamic (11)C-PIB scanning of 120 memory clinic patients was performed. Parametric nondisplaceable binding potential (BPND) images were compared with standardized uptake value (SUV) and SUV ratio images. Images were visually assessed by 3 independent readers, and both interreader and intermethod agreement was determined.

RESULTS: Both 90-min (Fleiss κ = 0.88) and 60-min (Fleiss κ = 0.89) BPND images showed excellent interreader agreement, whereas agreement was good to moderate for SUV ratio images (Fleiss κ = 0.68) and SUV images (Fleiss κ = 0.59). Intermethod agreement varied substantially between readers, although BPND images consistently showed the best performance.

CONCLUSION: The use of BPND images provided the highest interreader and intermethod agreement and is therefore the method of choice for optimal visual interpretation of (11)C-PIB PET scans.

Original language	English
Pages (from-to)	1305-7
Number of pages	3
Journal	Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Volume	55
Issue number	8
DOIs	https://doi.org/10.2967/jnumed.114.139121
Publication status	Published - Aug 2014
Externally published	Yes

Keywords

Aged
Amyloid/metabolism
Aniline Compounds
Benzothiazoles
Dementia/diagnostic imaging
Female
Humans
Image Interpretation, Computer-Assisted/methods
Male
Observer Variation
Positron-Emission Tomography
Thiazoles

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10.2967/jnumed.114.139121

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Zwan, M. D., Ossenkoppele, R., Tolboom, N., Beunders, A. J. M., Kloet, R. W., Adriaanse, S. M., Boellaard, R., Windhorst, A. D., Raijmakers, P., Adams, H., Lammertsma, A. A., Scheltens, P., van der Flier, W. M., & van Berckel, B. N. M. (2014). Comparison of simplified parametric methods for visual interpretation of 11C-Pittsburgh compound-B PET images. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 55(8), 1305-7. https://doi.org/10.2967/jnumed.114.139121

@article{3fca66cc4bf74e2a8759e442a00d30c7,

title = "Comparison of simplified parametric methods for visual interpretation of 11C-Pittsburgh compound-B PET images",

abstract = "UNLABELLED: This study compared several parametric imaging methods to determine the optimal approach for visual assessment of parametric Pittsburgh compound-B ((11)C-PIB) PET images to detect cortical amyloid deposition in different memory clinic patient groups.METHODS: Dynamic (11)C-PIB scanning of 120 memory clinic patients was performed. Parametric nondisplaceable binding potential (BPND) images were compared with standardized uptake value (SUV) and SUV ratio images. Images were visually assessed by 3 independent readers, and both interreader and intermethod agreement was determined.RESULTS: Both 90-min (Fleiss κ = 0.88) and 60-min (Fleiss κ = 0.89) BPND images showed excellent interreader agreement, whereas agreement was good to moderate for SUV ratio images (Fleiss κ = 0.68) and SUV images (Fleiss κ = 0.59). Intermethod agreement varied substantially between readers, although BPND images consistently showed the best performance.CONCLUSION: The use of BPND images provided the highest interreader and intermethod agreement and is therefore the method of choice for optimal visual interpretation of (11)C-PIB PET scans.",

keywords = "Aged, Amyloid/metabolism, Aniline Compounds, Benzothiazoles, Dementia/diagnostic imaging, Female, Humans, Image Interpretation, Computer-Assisted/methods, Male, Observer Variation, Positron-Emission Tomography, Thiazoles",

author = "Zwan, {Marissa D} and Rik Ossenkoppele and Nelleke Tolboom and Beunders, {Alexandra J M} and Kloet, {Reina W} and Adriaanse, {Sofie M} and Ronald Boellaard and Windhorst, {Albert D} and Pieter Raijmakers and Human Adams and Lammertsma, {Adriaan A} and Philip Scheltens and {van der Flier}, {Wiesje M} and {van Berckel}, {Bart N M}",

note = "{\textcopyright} 2014 by the Society of Nuclear Medicine and Molecular Imaging, Inc.",

year = "2014",

month = aug,

doi = "10.2967/jnumed.114.139121",

language = "English",

volume = "55",

pages = "1305--7",

journal = "Journal of nuclear medicine : official publication, Society of Nuclear Medicine",

issn = "0161-5505",

publisher = "Society of Nuclear Medicine Inc.",

number = "8",

}

Zwan, MD, Ossenkoppele, R, Tolboom, N, Beunders, AJM, Kloet, RW, Adriaanse, SM, Boellaard, R, Windhorst, AD, Raijmakers, P, Adams, H, Lammertsma, AA, Scheltens, P, van der Flier, WM & van Berckel, BNM 2014, 'Comparison of simplified parametric methods for visual interpretation of 11C-Pittsburgh compound-B PET images', Journal of nuclear medicine : official publication, Society of Nuclear Medicine, vol. 55, no. 8, pp. 1305-7. https://doi.org/10.2967/jnumed.114.139121

Comparison of simplified parametric methods for visual interpretation of 11C-Pittsburgh compound-B PET images. / Zwan, Marissa D; Ossenkoppele, Rik; Tolboom, Nelleke et al.
In: Journal of nuclear medicine : official publication, Society of Nuclear Medicine, Vol. 55, No. 8, 08.2014, p. 1305-7.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Comparison of simplified parametric methods for visual interpretation of 11C-Pittsburgh compound-B PET images

AU - Zwan, Marissa D

AU - Ossenkoppele, Rik

AU - Tolboom, Nelleke

AU - Beunders, Alexandra J M

AU - Kloet, Reina W

AU - Adriaanse, Sofie M

AU - Boellaard, Ronald

AU - Windhorst, Albert D

AU - Raijmakers, Pieter

AU - Adams, Human

AU - Lammertsma, Adriaan A

AU - Scheltens, Philip

AU - van der Flier, Wiesje M

AU - van Berckel, Bart N M

PY - 2014/8

Y1 - 2014/8

N2 - UNLABELLED: This study compared several parametric imaging methods to determine the optimal approach for visual assessment of parametric Pittsburgh compound-B ((11)C-PIB) PET images to detect cortical amyloid deposition in different memory clinic patient groups.METHODS: Dynamic (11)C-PIB scanning of 120 memory clinic patients was performed. Parametric nondisplaceable binding potential (BPND) images were compared with standardized uptake value (SUV) and SUV ratio images. Images were visually assessed by 3 independent readers, and both interreader and intermethod agreement was determined.RESULTS: Both 90-min (Fleiss κ = 0.88) and 60-min (Fleiss κ = 0.89) BPND images showed excellent interreader agreement, whereas agreement was good to moderate for SUV ratio images (Fleiss κ = 0.68) and SUV images (Fleiss κ = 0.59). Intermethod agreement varied substantially between readers, although BPND images consistently showed the best performance.CONCLUSION: The use of BPND images provided the highest interreader and intermethod agreement and is therefore the method of choice for optimal visual interpretation of (11)C-PIB PET scans.

AB - UNLABELLED: This study compared several parametric imaging methods to determine the optimal approach for visual assessment of parametric Pittsburgh compound-B ((11)C-PIB) PET images to detect cortical amyloid deposition in different memory clinic patient groups.METHODS: Dynamic (11)C-PIB scanning of 120 memory clinic patients was performed. Parametric nondisplaceable binding potential (BPND) images were compared with standardized uptake value (SUV) and SUV ratio images. Images were visually assessed by 3 independent readers, and both interreader and intermethod agreement was determined.RESULTS: Both 90-min (Fleiss κ = 0.88) and 60-min (Fleiss κ = 0.89) BPND images showed excellent interreader agreement, whereas agreement was good to moderate for SUV ratio images (Fleiss κ = 0.68) and SUV images (Fleiss κ = 0.59). Intermethod agreement varied substantially between readers, although BPND images consistently showed the best performance.CONCLUSION: The use of BPND images provided the highest interreader and intermethod agreement and is therefore the method of choice for optimal visual interpretation of (11)C-PIB PET scans.

KW - Aged

KW - Amyloid/metabolism

KW - Aniline Compounds

KW - Benzothiazoles

KW - Dementia/diagnostic imaging

KW - Female

KW - Humans

KW - Image Interpretation, Computer-Assisted/methods

KW - Male

KW - Observer Variation

KW - Positron-Emission Tomography

KW - Thiazoles

U2 - 10.2967/jnumed.114.139121

DO - 10.2967/jnumed.114.139121

M3 - Article

C2 - 24898026

SN - 0161-5505

VL - 55

SP - 1305

EP - 1307

JO - Journal of nuclear medicine : official publication, Society of Nuclear Medicine

JF - Journal of nuclear medicine : official publication, Society of Nuclear Medicine

IS - 8

ER -

Comparison of simplified parametric methods for visual interpretation of 11C-Pittsburgh compound-B PET images

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Keywords

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