Comparison of neonatal morbidity and mortality between single-room and open-bay care: a retrospective cohort study

Sophie Jansen, Romy J M Berkhout, Arjan B Te Pas, Sylke J Steggerda, Linda S de Vries, Nicoline Schalij-Delfos, Alieke van der Hoeven, Enrico Lopriore, Vincent Bekker

Research output: Contribution to journalArticleAcademicpeer-review


Objective In response to the increasing focus on family-centred care, neonatal intensive care unit (NICU) environments have gradually shifted towards the single-room design. However, the assumed benefits of this emerging design remain a subject of debate. Our goal was to evaluate the impact of single-room versus open-bay care on the risk of neonatal morbidity and mortality in preterm neonates. Design Retrospective cohort study. Setting Level III NICU. Patients Neonates born <32 weeks' gestation between 15 May 2015 and 15 May 2019. Main outcome measures Mortality and morbidities of a cohort of neonates admitted to a new, single-room unit (SRU) were compared with a historical cohort of neonates admitted to an open-bay unit (OBU). Group differences were evaluated and multivariable logistic regression analyses were performed. Results Three-hundred and fifty-six and 343 neonates were admitted to the SRU and OBU, respectively. No difference in neonatal morbidities and mortality were observed between cohorts (bronchopulmonary dysplasia: OR 1.08, 95% CI 0.73 to 1.58, p=0.44; retinopathy of the prematurity stage ≥2: OR 1.36, 95% CI 0.84 to 2.22, p=0.10; intraventricular haemorrhage: OR 0.89, 95% CI 0.59 to 1.34, p=0.86; mortality: OR 1.55, 95% CI 0.75 to 3.20, p=0.28). In adjusted regression models, single-room care was independently associated with a decreased risk of symptomatic patent ductus arteriosus (adjusted OR 0.54, 95% CI 0.31 to 0.95). No independent association between single-room care and any of the other investigated outcomes was observed. Conclusions Implementation of single-rooms in our NICU did not lead to a significant reduction in neonatal morbidity and mortality outcomes.

Original languageEnglish
Pages (from-to)611-616
Number of pages6
JournalArchives of Disease in Childhood Fetal and Neonatal Edition
Issue number6
Early online date20 Apr 2022
Publication statusPublished - Nov 2022
Externally publishedYes


  • Intensive Care Units
  • Mortality
  • Neonatal
  • Neonatology
  • Intensive Care Units, Neonatal


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