TY - JOUR
T1 - Comparison of multi-delay FAIR and pCASL labeling approaches for renal perfusion quantification at 3T MRI
AU - Harteveld, Anita A
AU - de Boer, Anneloes
AU - Franklin, Suzanne Lisa
AU - Leiner, Tim
AU - van Stralen, Marijn
AU - Bos, Clemens
N1 - Funding Information:
We thank MeVis Medical Solutions AG (Bremen, Germany) for providing MeVisLab medical image processing and visualization environment, which was used for image processing and analysis. This work is part of the research program Applied and Engineering Sciences with project number 14951 which is (partly) financed by the Netherlands Organization for Scientific Research (NWO). A.B. was supported by an Alexandre Suerman stipend for MD-PhD students by the University Medical Center Utrecht, The Netherlands.
Funding Information:
We thank MeVis Medical Solutions AG (Bremen, Germany) for providing MeVisLab medical image processing and visualization environment, which was used for image processing and analysis. This work is part of the research program Applied and Engineering Sciences with project number 14951 which is (partly) financed by the Netherlands Organization for Scientific Research (NWO). A.B. was supported by an Alexandre Suerman stipend for MD-PhD students by the University Medical Center Utrecht, The Netherlands.
Publisher Copyright:
© 2019, The Author(s).
PY - 2020/2
Y1 - 2020/2
N2 - OBJECTIVE: To compare the most commonly used labeling approaches, flow-sensitive alternating inversion recovery (FAIR) and pseudocontinuous arterial spin labeling (pCASL), for renal perfusion measurement using arterial spin labeling (ASL) MRI.METHODS: Multi-delay FAIR and pCASL were performed in 16 middle-aged healthy volunteers on two different occasions at 3T. Relative perfusion-weighted signal (PWS), temporal SNR (tSNR), renal blood flow (RBF), and arterial transit time (ATT) were calculated for the cortex and medulla in both kidneys. Bland-Altman plots, intra-class correlation coefficient, and within-subject coefficient of variation were used to assess reliability and agreement between measurements.RESULTS: For the first visit, RBF was 362 ± 57 and 140 ± 47 mL/min/100 g, and ATT was 0.47 ± 0.13 and 0.70 ± 0.10 s in cortex and medulla, respectively, using FAIR; RBF was 201 ± 72 and 84 ± 27 mL/min/100 g, and ATT was 0.71 ± 0.25 and 0.86 ± 0.12 s in cortex and medulla, respectively, using pCASL. For both labeling approaches, RBF and ATT values were not significantly different between visits. Overall, FAIR showed higher PWS and tSNR. Moreover, repeatability of perfusion parameters was better using FAIR.DISCUSSION: This study showed that compared to (balanced) pCASL, FAIR perfusion values were significantly higher and more comparable between visits.
AB - OBJECTIVE: To compare the most commonly used labeling approaches, flow-sensitive alternating inversion recovery (FAIR) and pseudocontinuous arterial spin labeling (pCASL), for renal perfusion measurement using arterial spin labeling (ASL) MRI.METHODS: Multi-delay FAIR and pCASL were performed in 16 middle-aged healthy volunteers on two different occasions at 3T. Relative perfusion-weighted signal (PWS), temporal SNR (tSNR), renal blood flow (RBF), and arterial transit time (ATT) were calculated for the cortex and medulla in both kidneys. Bland-Altman plots, intra-class correlation coefficient, and within-subject coefficient of variation were used to assess reliability and agreement between measurements.RESULTS: For the first visit, RBF was 362 ± 57 and 140 ± 47 mL/min/100 g, and ATT was 0.47 ± 0.13 and 0.70 ± 0.10 s in cortex and medulla, respectively, using FAIR; RBF was 201 ± 72 and 84 ± 27 mL/min/100 g, and ATT was 0.71 ± 0.25 and 0.86 ± 0.12 s in cortex and medulla, respectively, using pCASL. For both labeling approaches, RBF and ATT values were not significantly different between visits. Overall, FAIR showed higher PWS and tSNR. Moreover, repeatability of perfusion parameters was better using FAIR.DISCUSSION: This study showed that compared to (balanced) pCASL, FAIR perfusion values were significantly higher and more comparable between visits.
KW - Arterial spin labeling (ASL)
KW - Arterial transit time
KW - Kidney
KW - Magnetic resonance imaging
KW - Renal blood flow
UR - http://www.scopus.com/inward/record.url?scp=85076281431&partnerID=8YFLogxK
U2 - 10.1007/s10334-019-00806-7
DO - 10.1007/s10334-019-00806-7
M3 - Article
C2 - 31811490
SN - 1352-8661
VL - 33
SP - 81
EP - 94
JO - Magma: Magnetic Resonance Materials in Physics, Biology, and Medicine
JF - Magma: Magnetic Resonance Materials in Physics, Biology, and Medicine
IS - 1
ER -