Comparison of epithelial dysplasia-the 4NQO rat palate model and human oral mucosa

J. M. Nauta; J. L.N. Roodenburg; P. G.J. Nikkels; M. J.H. Witjes; A. Vermey

doi:10.1016/S0901-5027(05)80857-4

Comparison of epithelial dysplasia-the 4NQO rat palate model and human oral mucosa

J. M. Nauta^*, J. L.N. Roodenburg, P. G.J. Nikkels, M. J.H. Witjes, A. Vermey

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Epithelial dysplasia in the rat palatal mucosa was induced by application three times a week of the carcinogen 4-nitroquinoline 1-oxide (4NQO). With the Epithelial Atypia Index (EAI), the successive stages of 4NQO-induced epithelial dysplasia were compared with specimens of human oral epithelial dysplasia. It appeared that there was a close similarity between the histologic features of 4NQO-induced dysplasia in the rat palatal mucosa and human oral epithelial dysplaisa. Thus, the 4NQO rat palate model seems to be appropriate to study and assess new treatment modalities of premalignant epithelial lesions of the oral mucosa in man.

Original language	English
Pages (from-to)	53-58
Number of pages	6
Journal	International Journal of Oral and Maxillofacial Surgery
Volume	24
Issue number	1 PART 1
DOIs	https://doi.org/10.1016/S0901-5027(05)80857-4
Publication status	Published - 1 Jan 1995

Keywords

4-nitroquinoline 1-oxide
carcinogens
carcinoma
epithelium
nitroquinolines
palate
precancerous conditions
rats

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10.1016/S0901-5027(05)80857-4

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title = "Comparison of epithelial dysplasia-the 4NQO rat palate model and human oral mucosa",

abstract = "Epithelial dysplasia in the rat palatal mucosa was induced by application three times a week of the carcinogen 4-nitroquinoline 1-oxide (4NQO). With the Epithelial Atypia Index (EAI), the successive stages of 4NQO-induced epithelial dysplasia were compared with specimens of human oral epithelial dysplasia. It appeared that there was a close similarity between the histologic features of 4NQO-induced dysplasia in the rat palatal mucosa and human oral epithelial dysplaisa. Thus, the 4NQO rat palate model seems to be appropriate to study and assess new treatment modalities of premalignant epithelial lesions of the oral mucosa in man.",

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T1 - Comparison of epithelial dysplasia-the 4NQO rat palate model and human oral mucosa

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AU - Roodenburg, J. L.N.

AU - Nikkels, P. G.J.

AU - Witjes, M. J.H.

AU - Vermey, A.

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AB - Epithelial dysplasia in the rat palatal mucosa was induced by application three times a week of the carcinogen 4-nitroquinoline 1-oxide (4NQO). With the Epithelial Atypia Index (EAI), the successive stages of 4NQO-induced epithelial dysplasia were compared with specimens of human oral epithelial dysplasia. It appeared that there was a close similarity between the histologic features of 4NQO-induced dysplasia in the rat palatal mucosa and human oral epithelial dysplaisa. Thus, the 4NQO rat palate model seems to be appropriate to study and assess new treatment modalities of premalignant epithelial lesions of the oral mucosa in man.

KW - 4-nitroquinoline 1-oxide

KW - carcinogens

KW - carcinoma

KW - epithelium

KW - nitroquinolines

KW - palate

KW - precancerous conditions

KW - rats

UR - https://www.scopus.com/pages/publications/0029245045

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JO - International Journal of Oral and Maxillofacial Surgery

JF - International Journal of Oral and Maxillofacial Surgery

IS - 1 PART 1

ER -

Comparison of epithelial dysplasia-the 4NQO rat palate model and human oral mucosa

Abstract

Keywords

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