TY - JOUR
T1 - Comparison of effects on systolic and diastolic left ventricular function of Nebivolol versus Atenolol in patients with uncomplicated essential hypertension
AU - Kamp, Otto
AU - Sieswerda, Gertjan T.
AU - Visser, Cees A.
PY - 2003/8/1
Y1 - 2003/8/1
N2 - This was a double-blind, randomized, prospective study comparing the effects of nebivolol and atenolol on systolic diastolic left ventricular function in patients with essential hypertension. A significant difference was seen in stroke volume between these 2 drugs. The blood pressure lowering effect of atenolol was strongly related to cardiac output and heart rate reduction. The blood pressure lowering effect of nebivolol was related to a reduction in peripheral resistance and an increase in stroke volume with preservation of cardiac output. This preservation of cardiac output, together with a reduced peripheral resistance, may be potentially important in treating heart failure.
AB - This was a double-blind, randomized, prospective study comparing the effects of nebivolol and atenolol on systolic diastolic left ventricular function in patients with essential hypertension. A significant difference was seen in stroke volume between these 2 drugs. The blood pressure lowering effect of atenolol was strongly related to cardiac output and heart rate reduction. The blood pressure lowering effect of nebivolol was related to a reduction in peripheral resistance and an increase in stroke volume with preservation of cardiac output. This preservation of cardiac output, together with a reduced peripheral resistance, may be potentially important in treating heart failure.
UR - http://www.scopus.com/inward/record.url?scp=0041846431&partnerID=8YFLogxK
U2 - 10.1016/S0002-9149(03)00645-3
DO - 10.1016/S0002-9149(03)00645-3
M3 - Article
C2 - 12888152
AN - SCOPUS:0041846431
SN - 0002-9149
VL - 92
SP - 344
EP - 348
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 3
ER -