Comparison of effects on systolic and diastolic left ventricular function of Nebivolol versus Atenolol in patients with uncomplicated essential hypertension

Otto Kamp*, Gertjan T. Sieswerda, Cees A. Visser

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

107 Citations (Scopus)

Abstract

This was a double-blind, randomized, prospective study comparing the effects of nebivolol and atenolol on systolic diastolic left ventricular function in patients with essential hypertension. A significant difference was seen in stroke volume between these 2 drugs. The blood pressure lowering effect of atenolol was strongly related to cardiac output and heart rate reduction. The blood pressure lowering effect of nebivolol was related to a reduction in peripheral resistance and an increase in stroke volume with preservation of cardiac output. This preservation of cardiac output, together with a reduced peripheral resistance, may be potentially important in treating heart failure.

Original languageEnglish
Pages (from-to)344-348
Number of pages5
JournalAmerican Journal of Cardiology
Volume92
Issue number3
DOIs
Publication statusPublished - 1 Aug 2003
Externally publishedYes

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