Comparative study of peripheral nerve Mri and ultrasound in multifocal motor neuropathy and amyotrophic lateral sclerosis

BA Jongbloed; Wieke Haakma; H. Stephan Goedee; Jeroen W. Bos; Clemens Bos; Jeroen Hendrikse; Leonard H. Van Den Berg; W. Ludo Van Der Pol

doi:10.1002/mus.25391

Comparative study of peripheral nerve Mri and ultrasound in multifocal motor neuropathy and amyotrophic lateral sclerosis

BA Jongbloed, Wieke Haakma, H. Stephan Goedee, Jeroen W. Bos, Clemens Bos, Jeroen Hendrikse, Leonard H. Van Den Berg, W. Ludo Van Der Pol

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

INTRODUCTION: Differentiating multifocal motor neuropathy (MMN) from amyotrophic lateral sclerosis (ALS) is important, as MMN is a difficult, but treatable disorder.

METHODS: We studied peripheral nerve imaging techniques in differentiating MMN from ALS by measuring the cross-sectional area (CSA) of the median and ulnar nerves in the forearms using high resolution ultrasound (HRUS) and magnetic resonance imaging (MRI).

RESULTS: HRUS CSA values of the median nerve in the forearm (P =0.002) and the ulnar nerve distal to the sulcus (P =0.009) were significantly enlarged in patients with MMN. There was a positive correlation between CSA as measured with HRUS and MRI (Spearman rho 0.60, P<0.001).

Original language	English
Pages (from-to)	1133-1135
Number of pages	3
Journal	Muscle & Nerve
Volume	54
Issue number	6
DOIs	https://doi.org/10.1002/mus.25391
Publication status	Published - 1 Dec 2016

Keywords

ALS
HRUS
MMN
MRI
peripheral nerve

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title = "Comparative study of peripheral nerve Mri and ultrasound in multifocal motor neuropathy and amyotrophic lateral sclerosis",

abstract = "INTRODUCTION: Differentiating multifocal motor neuropathy (MMN) from amyotrophic lateral sclerosis (ALS) is important, as MMN is a difficult, but treatable disorder.METHODS: We studied peripheral nerve imaging techniques in differentiating MMN from ALS by measuring the cross-sectional area (CSA) of the median and ulnar nerves in the forearms using high resolution ultrasound (HRUS) and magnetic resonance imaging (MRI).RESULTS: HRUS CSA values of the median nerve in the forearm (P =0.002) and the ulnar nerve distal to the sulcus (P =0.009) were significantly enlarged in patients with MMN. There was a positive correlation between CSA as measured with HRUS and MRI (Spearman rho 0.60, P<0.001).CONCLUSION: Peripheral nerve imaging is a potentially powerful technique to distinguish MMN from ALS. This article is protected by copyright. All rights reserved.",

keywords = "ALS, HRUS, MMN, MRI, peripheral nerve",

author = "BA Jongbloed and Wieke Haakma and Goedee, {H. Stephan} and Bos, {Jeroen W.} and Clemens Bos and Jeroen Hendrikse and {Van Den Berg}, {Leonard H.} and {Van Der Pol}, {W. Ludo}",

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doi = "10.1002/mus.25391",

language = "English",

volume = "54",

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journal = "Muscle & Nerve",

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T1 - Comparative study of peripheral nerve Mri and ultrasound in multifocal motor neuropathy and amyotrophic lateral sclerosis

AU - Jongbloed, BA

AU - Haakma, Wieke

AU - Goedee, H. Stephan

AU - Bos, Jeroen W.

AU - Bos, Clemens

AU - Hendrikse, Jeroen

AU - Van Den Berg, Leonard H.

AU - Van Der Pol, W. Ludo

PY - 2016/12/1

Y1 - 2016/12/1

N2 - INTRODUCTION: Differentiating multifocal motor neuropathy (MMN) from amyotrophic lateral sclerosis (ALS) is important, as MMN is a difficult, but treatable disorder.METHODS: We studied peripheral nerve imaging techniques in differentiating MMN from ALS by measuring the cross-sectional area (CSA) of the median and ulnar nerves in the forearms using high resolution ultrasound (HRUS) and magnetic resonance imaging (MRI).RESULTS: HRUS CSA values of the median nerve in the forearm (P =0.002) and the ulnar nerve distal to the sulcus (P =0.009) were significantly enlarged in patients with MMN. There was a positive correlation between CSA as measured with HRUS and MRI (Spearman rho 0.60, P<0.001).CONCLUSION: Peripheral nerve imaging is a potentially powerful technique to distinguish MMN from ALS. This article is protected by copyright. All rights reserved.

AB - INTRODUCTION: Differentiating multifocal motor neuropathy (MMN) from amyotrophic lateral sclerosis (ALS) is important, as MMN is a difficult, but treatable disorder.METHODS: We studied peripheral nerve imaging techniques in differentiating MMN from ALS by measuring the cross-sectional area (CSA) of the median and ulnar nerves in the forearms using high resolution ultrasound (HRUS) and magnetic resonance imaging (MRI).RESULTS: HRUS CSA values of the median nerve in the forearm (P =0.002) and the ulnar nerve distal to the sulcus (P =0.009) were significantly enlarged in patients with MMN. There was a positive correlation between CSA as measured with HRUS and MRI (Spearman rho 0.60, P<0.001).CONCLUSION: Peripheral nerve imaging is a potentially powerful technique to distinguish MMN from ALS. This article is protected by copyright. All rights reserved.

KW - ALS

KW - HRUS

KW - MMN

KW - MRI

KW - peripheral nerve

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U2 - 10.1002/mus.25391

DO - 10.1002/mus.25391

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C2 - 27571543

SN - 0148-639X

VL - 54

SP - 1133

EP - 1135

JO - Muscle & Nerve

JF - Muscle & Nerve

IS - 6

ER -

Comparative study of peripheral nerve Mri and ultrasound in multifocal motor neuropathy and amyotrophic lateral sclerosis

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